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⊟Summary[edit | edit source]
- pan ID?: SAUPAN004238000
- symbol?: dtd
- synonym:
- description?: D-tyrosyl-tRNA(Tyr) deacylase
- D-tyrosyl-tRNA(Tyr) deacylase
- D-aminoacyl-tRNA deacylase
- pseudogene
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 4483804..4484256
- synteny block?: BlockID0032660
- occurrence?: in 100% of 34 strains
dtd : D-tyrosyl-tRNA(Tyr) deacylase [1]
Aminoacyl tRNA synthetases can occasionally mistakenly activate and tether D-amino acids to their cognate tRNAs where they can corrupt protein synthesis. Although originally described for its tRNA(Tyr) proofreading capacity, dtd can remove D-amino acids from several tRNAs and may play a role in removing mischarged glycyl-tRNA(Ala).
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1591
08BA02176:
C248_1676 (dtd)
11819-97:
MS7_1648 (dtd)
6850:
RSAU_001494 (dtd)
71193:
ST398NM01_1696
ECT-R 2:
ECTR2_1481 (dtd)
ED133:
SAOV_1630 (dtd)
ED98:
SAAV_1626
HO 5096 0412:
SAEMRSA15_15500
JH1:
SaurJH1_1723
JH9:
SaurJH9_1690
JKD6008:
SAA6008_01602 (dtd)
JKD6159:
SAA6159_01565 (dtd)
JSNZ:
JSNZ_001623 (dtd)
LGA251:
SARLGA251_15350
M013:
M013TW_1653
MRSA252:
SAR1713
MSHR1132:
SAMSHR1132_14690
MSSA476:
SAS1569
Mu3:
SAHV_1620
Mu50:
SAV1633
MW2:
MW1583
RF122:
SAB1502c (dtd)
ST398:
SAPIG1696 (dtd)
T0131:
SAT0131_01732
TCH60:
HMPREF0772_11509 (dtd)
TW20:
SATW20_16270
USA300_TCH1516:
USA300HOU_1631 (dtd)
VC40:
SAVC_07410
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKVVVQRVKEASVTNDTLNNQIKKGYCLLVGIGQNSTEQDADVIAKKIANARLFEDDNNK
N315 MKVVVQRVKEASVTNDTLNNQIKKGYCLLVGIGQNSTEQDADVIAKKIANARLFEDDNNK
NCTC8325 MKVVVQRVKEASVTNDTLNNQIKKGYCLLVGIGQNSTEQDADVIAKKIANARLFEDDNNK
Newman MKVVVQRVKEASVTNDTLNNQIKKGYCLLVGIGQNSTEQDADVIAKKIANARLFEDDNNK
USA300_FPR3757 MKVVVQRVKEASVTNDTLNNQIKKGYCLLVGIGQNSTEQDADVIAKKIANARLFEDDNNK
************************************************************
COL LNFNIQQMNGEILSVSQFTLYADVKKGNRPGFSNSKNPDQAVKIYEYFNDALRAYGLTVK
N315 LNFNIQQMNGEILSVSQFTLYADVKKGNRPGFSNSKNPDQAVKIYEYFNDALRAYGLTVK
NCTC8325 LNFNIQQMNGEILSVSQFTLYADVKKGNRPGFSNSKNPDQAVKIYEYFNDALRAYGLTVK
Newman LNFNIQQMNGEILSVSQFTLYADVKKGNRPGFSNSKNPDQAVKIYEYFNDALRAYGLTVK
USA300_FPR3757 LNFNIQQMNGEILSVSQFTLYADVKKGNRPGFSNSKNPDQAVKIYEYFNDALRAYGLTVK
************************************************************
COL TGEFGTHMNVSINNDGPVTIIYESQDGKIQ
N315 TGEFGTHMNVSINNDGPVTIIYESQDGKIQ
NCTC8325 TGEFGTHMNVSINNDGPVTIIYESQDGKIQ
Newman TGEFGTHMNVSINNDGPVTIIYESQDGKIQ
USA300_FPR3757 TGEFGTHMNVSINNDGPVTIIYESQDGKIQ
******************************
- ↑ Natalia V Geraskina, Ivan A Butov, Yurgis A V Yomantas, Nataliya V Stoynova
The dtd gene from Bacillus amyloliquefaciens encodes a putative D-tyrosyl-tRNATyr deacylase and is a selectable marker for Bacillus subtilis.
Microbiol Res: 2015, 171;90-6
[PubMed:25441601] [WorldCat.org] [DOI] (I p)Satya Brata Routh, Komal Ishwar Pawar, Sadeem Ahmad, Swati Singh, Katta Suma, Mantu Kumar, Santosh Kumar Kuncha, Kranthikumar Yadav, Shobha P Kruparani, Rajan Sankaranarayanan
Elongation Factor Tu Prevents Misediting of Gly-tRNA(Gly) Caused by the Design Behind the Chiral Proofreading Site of D-Aminoacyl-tRNA Deacylase.
PLoS Biol: 2016, 14(5);e1002465
[PubMed:27224426] [WorldCat.org] [DOI] (I e)Richard Calendar
d-Tyrosyl-tRNA Deacylase: A New Function.
Trends Biochem Sci: 2017, 42(9);684-686
[PubMed:28764927] [WorldCat.org] [DOI] (I p)Santosh Kumar Kuncha, Katta Suma, Komal Ishwar Pawar, Jotin Gogoi, Satya Brata Routh, Sambhavi Pottabathini, Shobha P Kruparani, Rajan Sankaranarayanan
A discriminator code-based DTD surveillance ensures faithful glycine delivery for protein biosynthesis in bacteria.
Elife: 2018, 7;
[PubMed:30091703] [WorldCat.org] [DOI] (I e)