⊟Summary[edit | edit source]
- pan ID?: SAUPAN003934000
- symbol?: hup
- synonym:
- description?: DNA-binding protein HU
- DNA-binding protein HU
- DNA-binding protein II
- HU family DNA-binding protein
- DNA-binding protein HBsu
- DNA-binding protein HU 1 (DNA-binding protein II) (HB)
- DNA-binding protein II HBsu
- histone family protein DNA-binding protein
- histone family protein DNA-binding protein HU
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 4252465..4252737
- synteny block?: BlockID0029800
- occurrence?: in 100% of 34 strains
hup (hSau) : DNA replication initiation and transcriptional regulator protein HU [1]
• A crystal structure is available : 8HD5
Histone-like nucleoid-associated proteins are poorly-characterized DNA-binding proteins with many proposed functions, including condensing DNA into a nucleoid, protecting DNA from degradation and providing structure to support the formation of transcription bubbles. Although typically non-essential individually due to functional redundancy, HU is an essential protein in both S. aureus and B. subtilis. Extrapolating from studies in Bacillus subtilis, HU likely participates with DnaA in initiation of chromosomal DNA replication but has additional, undescribed essential functions. Additional evidence suggests HU can also participate in transcription regulation by wrapping DNA in such a way that exposes some promoters and prevents display of others. Formal nomenclature for this protein has not yet been established; the orthologue from E. coli is protein HU, the orthologue from Bacillus subtilis added "Bs" to make HBsu. Whether Staphylococcus aureus goes with "HU" or "HSau" nomenclature is not yet certain. Of note, the HBsu-specific lysine N-acetyltransferase YfmK does not have a clear orthologue in staphylococci so it is not clear if staphylococcal HU is acetylated.
⊟Orthologs[edit | edit source]
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MNKTDLINAVAEQADLTKKEAGSAVDAVFESIQNSLAKGEKVQLIGFGNFEVRERAARKG
N315 MNKTDLINAVAEQADLTKKEAGSAVDAVFESIQNSLAKGEKVQLIGFGNFEVRERAARKG
NCTC8325 MNKTDLINAVAEQADLTKKEAGSAVDAVFESIQNSLAKGEKVQLIGFGNFEVRERAARKG
Newman MNKTDLINAVAEQADLTKKEAGSAVDAVFESIQNSLAKGEKVQLIGFGNFEVRERAARKG
USA300_FPR3757 MNKTDLINAVAEQADLTKKEAGSAVDAVFESIQNSLAKGEKVQLIGFGNFEVRERAARKG
************************************************************
COL RNPQTGKEIDIPASKVPAFKAGKALKDAVK
N315 RNPQTGKEIDIPASKVPAFKAGKALKDAVK
NCTC8325 RNPQTGKEIDIPASKVPAFKAGKALKDAVK
Newman RNPQTGKEIDIPASKVPAFKAGKALKDAVK
USA300_FPR3757 RNPQTGKEIDIPASKVPAFKAGKALKDAVK
******************************
- ↑ Xheni Karaboja, Xindan Wang
HBsu Is Required for the Initiation of DNA Replication in Bacillus subtilis.
J Bacteriol: 2022, 204(8);e0011922
[PubMed:35546541] [WorldCat.org] [DOI] (I p)Maria D Barbuti, Ine S Myrbråten, Danae Morales Angeles, Morten Kjos
The cell cycle of Staphylococcus aureus: An updated review.
Microbiologyopen: 2023, 12(1);e1338
[PubMed:36825883] [WorldCat.org] [DOI] (I p)