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⊟Summary[edit | edit source]

  • pan ID?: SAUPAN003830000
  • symbol?: sucB
  • synonym:
  • description?: dihydrolipoamide succinyltransferase

      descriptions from strain specific annotations:

    • dihydrolipoamide succinyltransferase
    • dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex
    • dihydrolipoyllysine-residue succinyltransferase
    • dihydrolipoamide succinyltransferase, putative
    • Dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarate dehydrogenase complex
    • dihydrolipoamide succinyltransferase E2 component of 2-oxoglutarate dehydrogenase complex
    • dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex
    • dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglutarate dehydrogenase (succinyl-transferring) complex
  • strand?: -
  • coordinates?: 4119140..4120514
  • synteny block?: BlockID0028870
  • occurrence?: in 100% of 34 strains

sucB (odhB) : 2-oxoglutarate dehydrogenase E2 (dihydrolipoamide succinyltransferase) subunit [1]

2-oxoglutarate dehydrogenase (alt: alpha-ketoglutarate dehydrogenase complex, oxoglutarate dehydrogenase) catalyzes a coupled decarboxylation of alpha-ketoglutarate to succinate with thioesterification and transfer of succinate to CoA. The E1 component catalyzes the thiamine-dependent decarboxylation and attaches the succinate product to the lipoamide posttranslational modification of the E2 subunit. The E2 subunit then transfers the succinate from its lipoamide group onto a Coenzyme A resulting in succinyl-CoA.

⊟Orthologs[edit | edit source]

    COL:
    SACOL1448 (sucB)
    N315:
    SA1244 (odhB)
    NCTC8325:
    SAOUHSC_01416
    Newman:
    NWMN_1325 (sucB)
    USA300_FPR3757:
    SAUSA300_1305 (sucB)
    04-02981:
    SA2981_1366 (odhB)
    08BA02176:
    C248_1451 (odhB)
    11819-97:
    MS7_1368 (sucB)
    6850:
    RSAU_001292 (odhB)
    71193:
    ST398NM01_1414
    ECT-R 2:
    ECTR2_1269 (sucB)
    ED133:
    SAOV_1422c
    ED98:
    SAAV_1396 (sucB)
    HO 5096 0412:
    SAEMRSA15_12750 (odhB)
    JH1:
    SaurJH1_1502
    JH9:
    SaurJH9_1473
    JKD6008:
    SAA6008_01378 (odhB)
    JKD6159:
    SAA6159_01279 (odhB)
    JSNZ:
    JSNZ_001396 (sucB)
    LGA251:
    SARLGA251_13290 (odhB)
    M013:
    M013TW_1357
    MRSA252:
    SAR1424 (odhB)
    MSHR1132:
    SAMSHR1132_12530
    MSSA476:
    SAS1355
    Mu3:
    SAHV_1400 (odhB)
    Mu50:
    SAV1412 (odhB)
    MW2:
    MW1302 (odhB)
    RF122:
    SAB1268c (odhB)
    ST398:
    SAPIG1414 (sucB)
    T0131:
    SAT0131_01490
    TCH60:
    HMPREF0772_11797 (sucB)
    TW20:
    SATW20_14130 (odhB)
    USA300_TCH1516:
    USA300HOU_1347 (odhB)
    VC40:
    SAVC_06310

⊟Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

⊟Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MPEVKVPELAESITEGTIAEWLKNVGDSVEKGEAILELETDKVNVEVVSEEAGVLSEQLA
    N315            MPEVKVPELAESITEGTIAEWLKNVGDSVEKGEAILELETDKVNVEVVSEEAGVLSEQLA
    NCTC8325        MPEVKVPELAESITEGTIAEWLKNVGDSVEKGEAILELETDKVNVEVVSEEAGVLSEQLA
    Newman          MPEVKVPELAESITEGTIAEWLKNVGDSVEKGEAILELETDKVNVEVVSEEAGVLSEQLA
    USA300_FPR3757  MPEVKVPELAESITEGTIAEWLKNVGDSVEKGEAILELETDKVNVEVVSEEAGVLSEQLA
                    ************************************************************

    COL             SEGDTVEVGQAIAIIGEGSGNASKENSNDNTPQQNEETNNKKEETTNNSVDKAEVNQAND
    N315            SEGDTVEVGQAIAIIGEGSGNASKENSNDNTPQQNEETNNKKEETTNNSVDKAEVNQAND
    NCTC8325        SEGDTVEVGQAIAIIGEGSGNASKENSNDNTPQQNEETNNKKEETTNNSVDKAEVNQAND
    Newman          SEGDTVEVGQAIAIIGEGSGNASKENSNDNTPQQNEETNNKKEETTNNSVDKAEVNQAND
    USA300_FPR3757  SEGDTVEVGQAIAIIGEGSGNASKENSNDNTPQQNEETNNKKEETTNNSVDKAEVNQAND
                    ************************************************************

    COL             DNQQRINATPSARRYARENGVNLAEVSPKTNDVVRKEDIDKKQQAPASTQTTQQASAKEE
    N315            DNQQRINATPSARRYARENGVNLAEVSPKTNDVVRKEDIDKKQQAPASTQTTQQAPAKEE
    NCTC8325        DNQQRINATPSARRYARENGVNLAEVSPKTNDVVRKEDIDKKQQAPASTQTTQQASAKEE
    Newman          DNQQRINATPSARRYARENGVNLAEVSPKTNDVVRKEDIDKKQQAPASTQTTQQASAKEE
    USA300_FPR3757  DNQQRINATPSARRYARENGVNLAEVSPKTNDVVRKEDIDKKQQAPASTQTTQQASAKEE
                    *******************************************************.****

    COL             KKYNQYPTKPVIREKMSRRKKTAAKKLLEVSNNTAMLTTFNEVDMTNVMELRKRKKEQFM
    N315            KKYNQYPTKPVIREKMSRRKKTAAKKLLEVSNNTAMLTTFNEVDMTNVMELRKRKKEQFM
    NCTC8325        KKYNQYPTKPVIREKMSRRKKTAAKKLLEVSNNTAMLTTFNEVDMTNVMELRKRKKEQFM
    Newman          KKYNQYPTKPVIREKMSRRKKTAAKKLLEVSNNTAMLTTFNEVDMTNVMELRKRKKEQFM
    USA300_FPR3757  KKYNQYPTKPVIREKMSRRKKTAAKKLLEVSNNTAMLTTFNEVDMTNVMELRKRKKEQFM
                    ************************************************************

    COL             KDHDGTKLGFMSFFTKASVAALKKYPEVNAEIDGDDMITKQYYDIGVAVSTDDGLLVPFV
    N315            KDHDGTKLGFMSFFTKASVAALKKYPEVNAEIDGDDMITKQYYDIGVAVSTDDGLLVPFV
    NCTC8325        KDHDGTKLGFMSFFTKASVAALKKYPEVNAEIDGDDMITKQYYDIGVAVSTDDGLLVPFV
    Newman          KDHDGTKLGFMSFFTKASVAALKKYPEVNAEIDGDDMITKQYYDIGVAVSTDDGLLVPFV
    USA300_FPR3757  KDHDGTKLGFMSFFTKASVAALKKYPEVNAEIDGDDMITKQYYDIGVAVSTDDGLLVPFV
                    ************************************************************

    COL             RDCDKKNFAEIEAEIANLAVKAREKKLGLDDMVNGSFTITNGGIFGSMMSTPIINGNQAA
    N315            RDCDKKNFAEIEAEIANLAVKAREKKLGLDDMVNGSFTITNGGIFGSMMSTPIINGNQAA
    NCTC8325        RDCDKKNFAEIEAEIANLAVKAREKKLGLDDMVNGSFTITNGGIFGSMMSTPIINGNQAA
    Newman          RDCDKKNFAEIEAEIANLAVKAREKKLGLDDMVNGSFTITNGGIFGSMMSTPIINGNQAA
    USA300_FPR3757  RDCDKKNFAEIEAEIANLAVKAREKKLGLDDMVNGSFTITNGGIFGSMMSTPIINGNQAA
                    ************************************************************

    COL             ILGMHSIITRPIAIDQDTIENRPMMYIALSYDHRIIDGKEAVGFLKTIKELIENPEDLLL
    N315            ILGMHSIITRPIAIDQDTIENRPMMYIALSYDHRIIDGKEAVGFLKTIKELIENPEDLLL
    NCTC8325        ILGMHSIITRPIAIDQDTIENRPMMYIALSYDHRIIDGKEAVGFLKTIKELIENPEDLLL
    Newman          ILGMHSIITRPIAIDQDTIENRPMMYIALSYDHRIIDGKEAVGFLKTIKELIENPEDLLL
    USA300_FPR3757  ILGMHSIITRPIAIDQDTIENRPMMYIALSYDHRIIDGKEAVGFLKTIKELIENPEDLLL
                    ************************************************************

    COL             ES
    N315            ES
    NCTC8325        ES
    Newman          ES
    USA300_FPR3757  ES
                    **

  1. ↑ Ying Wang, Martin Saxtorph Bojer, Shilpa Elizabeth George, Zhihao Wang, Peter Ruhdal Jensen, Christiane Wolz, Hanne Ingmer
    Inactivation of TCA cycle enhances Staphylococcus aureus persister cell formation in stationary phase.
    Sci Rep: 2018, 8(1);10849
    [PubMed:30022089] [WorldCat.org] [DOI] (I e)    Christopher Campbell, Claire Fingleton, Merve S Zeden, Emilio Bueno, Laura A Gallagher, Dhananjay Shinde, Jongsam Ahn, Heather M Olson, Thomas L Fillmore, Joshua N Adkins, Fareha Razvi, Kenneth W Bayles, Paul D Fey, Vinai C Thomas, Felipe Cava, Geremy C Clair, James P O'Gara
    Accumulation of Succinyl Coenzyme A Perturbs the Methicillin-Resistant Staphylococcus aureus (MRSA) Succinylome and Is Associated with Increased Susceptibility to Beta-Lactam Antibiotics.
    mBio: 2021, 12(3);e0053021
    [PubMed:34182779] [WorldCat.org] [DOI] (I p)    Stefano G Giulieri, Romain Guérillot, Sebastian Duchene, Abderrahman Hachani, Diane Daniel, Torsten Seemann, Joshua S Davis, Steven Y C Tong, Bernadette C Young, Daniel J Wilson, Timothy P Stinear, Benjamin P Howden
    Niche-specific genome degradation and convergent evolution shaping Staphylococcus aureus adaptation during severe infections.
    Elife: 2022, 11;
    [PubMed:35699423] [WorldCat.org] [DOI] (I e)
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