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⊟Summary[edit | edit source]
- pan ID?: SAUPAN003766000
- symbol?: trpF
- synonym:
- description?: N-(5'-phosphoribosyl)anthranilate isomerase
- N-(5'-phosphoribosyl)anthranilate isomerase
- phosphoribosylanthranilate isomerase
- N-5'-phosphoriborylanthranilate isomerase
- N-(5'phosphoribosyl)anthranilate (PRA)isomerase
- N-(5'phosphoribosyl)anthranilate (PRA) isomerase family protein
- N-5'-phosphoribosyl-anthranilate isomerase
- transcription termination/antitermination factor NusG
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 4063501..4064025
- synteny block?: BlockID0028280
- occurrence?: in 100% of 34 strains
trpF : phosphoribosylanthranilate isomerase [1]
De novo tryptophan biosynthesis converts chorismate to tryptophan in five steps using seven proteins. Phosphoribosylanthranilate isomerase (PRAI, TrpF) performs the third committed step in tryptophan biosynthesis. PRAI opens the ribose ring of phosphoribosylanthranilate to generate the linear 1-carboxyphenylamino-1'-deoxyribulose-5'-phosphate.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1325
08BA02176:
C248_1409 (trpF)
11819-97:
MS7_1328
6850:
RSAU_001252 (trpF)
71193:
ST398NM01_1372
ECT-R 2:
ECTR2_1228
ED133:
SAOV_1381
ED98:
SAAV_1353 (trpF)
HO 5096 0412:
SAEMRSA15_12190 (trpF)
JH1:
SaurJH1_1461
JH9:
SaurJH9_1432
JKD6008:
SAA6008_01336 (trpF)
JKD6159:
SAA6159_01237 (trpF)
JSNZ:
JSNZ_001355
LGA251:
SARLGA251_12800 (trpF)
M013:
M013TW_1317
MRSA252:
SAR1384 (trpF)
MSHR1132:
SAMSHR1132_12140
MSSA476:
SAS1311
Mu3:
SAHV_1359 (trpF)
Mu50:
SAV1371 (trpF)
MW2:
MW1258 (trpF)
RF122:
SAB1226 (trpF)
ST398:
SAPIG1372 (trpF)
T0131:
SAT0131_01443 (sbi)
TCH60:
HMPREF0772_11836 (trpF)
TW20:
SATW20_13710 (trpF)
USA300_TCH1516:
USA300HOU_1306 (trpF)
VC40:
SAVC_06105
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MMKLKFCGFTSIKDVTAASQLPIDAIGFIHYEKSKRHQTITQIKKLASAVPNHIDKVCVM
N315 -MKLKFCGFTSIKDVTAASQLPIDAIGFIHYEKSKRHQTITQIKKLASAVPNHIDKVCVM
NCTC8325 -MKLKFCGFTSIKDVTAASQLPIDAIGFIHYEKSKRHQTITQIKKLASAVPNHIDKVCVM
Newman MMKLKFCGFTSIKDVTAASQLPIDAIGFIHYEKSKRHQTITQIKKLASAVPNHIDKVCVM
USA300_FPR3757 -MKLKFCGFTSIKDVTAASQLPIDAIGFIHYEKSKRHQTITQIKKLASAVPNHIDKVCVM
***********************************************************
COL VNPDLTTIEHVLSNTSINTIQLHGTESIDFIQEIKKKYSSIKITKALAADENIIQNINKY
N315 VNPDLTTIEHVLSNTSINTIQLHGTESIDFIQEIKKKYSSIKITKALAADENIIQNINKY
NCTC8325 VNPDLTTIEHVLSNTSINTIQLHGTESIDFIQEIKKKYSSIKITKALAADENIIQNINKY
Newman VNPDLTTIEHVLSNTSINTIQLHGTESIDFIQEIKKKYSSIKITKALAADENIIQNINKY
USA300_FPR3757 VNPDLTTIEHVLSNTSINTIQLHGTESIDFIQEIKKKYSSIKITKALAADENIIQNINKY
************************************************************
COL KGFVDLFIIDTPSVSYGGTGQTYDWTILKHIKDIPYLIAGGINSENIQTVNQLKLSHQGY
N315 KGFVDLFIIDTPSVSYGGTGQTYDWTILKHIKDIPYLIAGGINSENIQTVNQLKLSHQGY
NCTC8325 KGFVDLFIIDTPSVSYGGTGQTYDWTILKHIKDIPYLIAGGINSENIQTVNQLKLSHQGY
Newman KGFVDLFIIDTPSVSYGGTGQTYDWTILKHIKDIPYLIAGGINSENIQTVNQLKLSHQGY
USA300_FPR3757 KGFVDLFIIDTPSVSYGGTGQTYDWTILKHIKDIPYLIAGGINSENIQTVNQLKLSHQGY
************************************************************
COL DLASGIEVNGRKDIEKMTAIVNIVKGDRDNE
N315 DLASGIEVNGRKDIEKMTAIVNIVKGDRDNE
NCTC8325 DLASGIEVNGRKDIEKMTAIVNIVKGDRDNE
Newman DLASGIEVNGRKDIEKMTAIVNIVKGDRDNE
USA300_FPR3757 DLASGIEVNGRKDIEKMTAIVNIVKGDRDNE
*******************************
- ↑ A R Proctor, W E Kloos
Tryptophan biosynthetic enzymes of Staphylococcus aureus.
J Bacteriol: 1973, 114(1);169-77
[PubMed:4698207] [WorldCat.org] [DOI] (P p)