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⊟Summary[edit | edit source]
- pan ID?: SAUPAN003301000
- symbol?: rlmQ
- synonym:
- description?: class I SAM-dependent rRNA methyltransferase
- class I SAM-dependent rRNA methyltransferase
- SAM-dependent methyltransferase, putative
- 50S m5C1962 methyltransferase RlmI
- LSU m5C1962 methyltransferase RlmI
- Methyltransferase
- protein YwbD
- putative SAM-dependent methyltransferase
- putative SAM-dependent methyltransferases
- S-adenosylmethionine-dependent methyltransferase family protein
- SAM binding domain protein,PUA domain-containing protein
- SAM-dependent methyltransferase-like protein
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 3671820..3672992
- synteny block?: BlockID0023850
- occurrence?: in 100% of 34 strains
rlmQ : ribosome large subunit methyltransferase Q [1]
• A crystal structure is available : 3VSE
Ribosome large subunit methyltransferase Q (alt: ribosome large subunit nucleobase methyltransferase G, 23S rRNA guanosine(2601) N-(7)-methyltransferase) attaches a methyl group to the guanosine nucleobase 7-position of residue 2601 in 23S ribosomal RNA (S. aureus numbering; guanosine 2251 by E. coli numbering).
- 23S rRNA : G (2601) → m7G (2601)
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1037 (rlmI)
08BA02176:
C248_1107
11819-97:
MS7_1038
6850:
RSAU_000967
71193:
ST398NM01_1078
ECT-R 2:
ECTR2_936
ED133:
SAOV_1025
ED98:
SAAV_1046
HO 5096 0412:
SAEMRSA15_09110
JH1:
SaurJH1_1163
JH9:
SaurJH9_1141
JKD6008:
SAA6008_01036
JKD6159:
SAA6159_00937
JSNZ:
JSNZ_001045
LGA251:
SARLGA251_09940
M013:
M013TW_1013
MRSA252:
SAR1054
MSHR1132:
SAMSHR1132_09280
MSSA476:
SAS1016
Mu3:
SAHV_1073
Mu50:
SAV1081
MW2:
MW0963
RF122:
SAB0947
ST398:
SAPIG1078
T0131:
SAT0131_01117
TCH60:
HMPREF0772_12152 (ywbD)
TW20:
SATW20_10760
USA300_TCH1516:
USA300HOU_1023
VC40:
SAVC_04565
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKIATLNKGKETKYFNGYPLIEEEDIYSQDHLKEGDIFQIVTDKSQYVATAYVGRQHKGL
N315 MKIATLNKGKETKYFNGYPLIEEEDIYSQDHLKEGDIFQIVTDKSQYVATAYVGRQHKGL
NCTC8325 MKIATLNKGKETKYFNGYPLIEEEDIYSQDHLKEGDIFQIVTDKSQYVATAYVGRQHKGL
Newman MKIATLNKGKETKYFNGYPLIEEEDIYSQDHLKEGDIFQIVTDKSQYVATAYVGRQHKGL
USA300_FPR3757 MKIATLNKGKETKYFNGYPLIEEEDIYSQDHLKEGDIFQIVTDKSQYVATAYVGRQHKGL
************************************************************
COL GWVLTYDKAQQINTAFFVKLFNTALAERDYYFNIDGTNAFRLFNAEGDGVGGLTIDNYDG
N315 GWVLTYDKAQEINTAFFVKLFNTALAERDYYFNIDGTNAFRLFNAEGDGVGGLTIDNYDG
NCTC8325 GWVLTYDKAQQINTAFFVKLFNTALAERDYYFNIDGTNAFRLFNAEGDGVGGLTIDNYDG
Newman GWVLTYDKAQQINTAFFVKLFNTALAERDYYFNIDGTNAFRLFNAEGDGVGGLTIDNYDG
USA300_FPR3757 GWVLTYDKAQQINTAFFVKLFNTALAERDYYFNIDGTNAFRLFNAEGDGVGGLTIDNYDG
**********:*************************************************
COL HLLIQWYSKGIYKFKYAILEAVRKVFDYKSIYEKVRFKDSEYSGGFVEGDAPEFPIVIEE
N315 HLLIQWYSKGIYKFKYAILEAVRKVFDYKSIYEKVRFKDSEYSGGFVEGDAPEFPIVIEE
NCTC8325 HLLIQWYSKGIYKFKYAILEAVRKVFDYKSIYEKVRFKDSEYSGGFVEGDAPEFPIVIEE
Newman HLLIQWYSKGIYKFKYAILEAVRKVFDYKSIYEKVRFKDSEYSGGFVEGDAPEFPIVIEE
USA300_FPR3757 HLLIQWYSKGIYKFKYAILEAVRKVFDYKSIYEKVRFKDSEYSGGFVEGDAPEFPIVIEE
************************************************************
COL NFTFYNVDLEDGLMTGIFLDQKEVRKKLRDQYAKERHVLNLFSYTGAFSAIAASEASSTT
N315 NFTFYNVDLEDGLMTGIFLDQKEVRKKLRGQYAKERHVLNLFSYTGAFSVIAASEASSTT
NCTC8325 NFTFYNVDLEDGLMTGIFLDQKEVRKKLRDQYAKERHVLNLFSYTGAFSAIAASEASSTT
Newman NFTFYNVDLEDGLMTGIFLDQKEVRKKLRDQYAKERHVLNLFSYTGAFSAIAASEASSTT
USA300_FPR3757 NFTFYNVDLEDGLMTGIFLDQKEVRKKLRDQYAKERHVLNLFSYTGAFSAIAASEASSTT
*****************************.*******************.**********
COL SVDLANRSRSLTEENFGLNAIDPKSQYIYVMDTFDFYKYAARHGHSYDTIVIDPPSFARN
N315 SVDLANRSRSLTEENFGLNAIDPKSQYIYVMDTFDFYKYAARHGHSYDTIVIDPPSFARN
NCTC8325 SVDLANRSRSLTEENFGLNAIDPKSQYIYVMDTFDFYKYAARHGHSYDTIVIDPPSFARN
Newman SVDLANRSRSLTEENFGLNAIDPKSQYIYVMDTFDFYKYAARHGHSYDTIVIDPPSFARN
USA300_FPR3757 SVDLANRSRSLTEENFGLNAIDPKSQYIYVMDTFDFYKYAARHGHSYDTIVIDPPSFARN
************************************************************
COL KKRTFSVQKDYDKLINGALNILSSEGTLLLCTNASVYPLKQFKNTIKKTLEESGVDYELT
N315 KKRTFSVQKDYDKLINGALNILSSEGTLLLCTNASVYPLKQFKNTIKKTLEESGVDYELT
NCTC8325 KKRTFSVQKDYDKLINGALNILSSEGTLLLCTNASVYPLKQFKNTIKKTLEESGVDYELT
Newman KKRTFSVQKDYDKLINGALNILSSEGTLLLCTNASVYPLKQFKNTIKKTLEESGVDYELT
USA300_FPR3757 KKRTFSVQKDYDKLINGALNILSSEGTLLLCTNASVYPLKQFKNTIKKTLEESGVDYELT
************************************************************
COL EVMGLPKDFKTHPHYKPSKYLKAVFVNIRH
N315 EVMGLPKDFKTHPHYKPSKYLKAVFVNIRH
NCTC8325 EVMGLPKDFKTHPHYKPSKYLKAVFVNIRH
Newman EVMGLPKDFKTHPHYKPSKYLKAVFVNIRH
USA300_FPR3757 EVMGLPKDFKTHPHYKPSKYLKAVFVNIRH
******************************
- ↑ Shunsuke Kita, Yoshikazu Tanaka, Nagisa Hirano, Satoshi Kimura, Takeo Suzuki, Tsutomu Suzuki, Min Yao, Isao Tanaka
Crystal structure of a putative methyltransferase SAV1081 from Staphylococcus aureus.
Protein Pept Lett: 2013, 20(5);530-7
[PubMed:23016631] [WorldCat.org] [DOI] (I p)Alexander Golubev, Bulat Fatkhullin, Iskander Khusainov, Lasse Jenner, Azat Gabdulkhakov, Shamil Validov, Gulnara Yusupova, Marat Yusupov, Konstantin Usachev
Cryo-EM structure of the ribosome functional complex of the human pathogen Staphylococcus aureus at 3.2 Å resolution.
FEBS Lett: 2020, 594(21);3551-3567
[PubMed:32852796] [WorldCat.org] [DOI] (I p)Roberto Bahena-Ceron, Chloé Teixeira, Jose R Jaramillo Ponce, Philippe Wolff, Florence Couzon, Pauline François, Bruno P Klaholz, François Vandenesch, Pascale Romby, Karen Moreau, Stefano Marzi
RlmQ: a newly discovered rRNA modification enzyme bridging RNA modification and virulence traits in Staphylococcus aureus.
RNA: 2024, 30(3);200-212
[PubMed:38164596] [WorldCat.org] [DOI] (I e)Adrián González-López, Daniel S D Larsson, Ravi Kiran Koripella, Brett N Cain, Martin Garcia Chavez, Paul J Hergenrother, Suparna Sanyal, Maria Selmer
Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane.
Sci Rep: 2024, 14(1);14253
[PubMed:38902339] [WorldCat.org] [DOI] (I e)