⊟Summary[edit | edit source]

pan ID^?: SAUPAN003181000
symbol^?: cpaA
synonym:
description^?: sodium:proton antiporter
- sodium:proton antiporter
- cation:proton antiporter
- monovalent cation/H+ antiporter-2 (CPA2) family protein
- monovalent cation:proton antiporter-2 family protein
- transporter, monovalent cation:proton antiporter-2 (CPA2) family protein
- sodium/hydrogen exchanger
- CPA2 family monovalent cation:proton (H+) antiporter-2
- monovalent cation antiporter-2
- Na+/H+ antiporter homologue
- Na+/H+ antiporter-like protein
- Na+/H+ antiporter protein
- pseudogene
- putative cation transport protein
- sodium/hydrogen exchanger family protein
strand^?: +
coordinates^?: 3571628..3573472
synteny block^?: BlockID0022680
occurrence^?: in 100% of 34 strains

cpaA : cyclic di-AMP responsive potassium: proton antiporter CpaA ^[1]

• A crystal structure is available : 5F29

Bacteria use the second messenger signaling nucleotide cyclic-di-AMP to regulate internal osmotic pressure and maintain balance with both the environment and the cell wall integrity. High cyclic-di-AMP levels induce Cation Proton Antiporter protein A (CpaA) allosterically at its regulator of the conductance of K⁺ (RCK) C-terminal domain resulting in increased potassium export, reduced intracellular potassium and lower turgor pressure.

⊟Orthologs[edit | edit source]

COL:

N315:

NCTC8325:

Newman:

USA300_FPR3757:

04-02981:

SA2981_0964

08BA02176:

C248_1032

11819-97:

MS7_0965

6850:

RSAU_000888

71193:

ST398NM01_1005

ECT-R 2:

ECTR2_864

ED133:

SAOV_0955

ED98:

SAAV_0972

HO 5096 0412:

SAEMRSA15_08400

JH1:

SaurJH1_1027

JH9:

SaurJH9_1008

JKD6008:

SAA6008_00963

JKD6159:

SAA6159_00866

JSNZ:

JSNZ_000969

LGA251:

SARLGA251_09250

M013:

M013TW_0932

MRSA252:

SAR0977

MSHR1132:

SAMSHR1132_08570

MSSA476:

SAS0879

Mu3:

SAHV_1004

Mu50:

SAV1010

MW2:

MW0891

RF122:

SAB0876

ST398:

SAPIG1005

T0131:

SAT0131_01045

TCH60:

HMPREF0772_12227

TW20:

SATW20_10070

USA300_TCH1516:

USA300HOU_0967

VC40:

SAVC_04215

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

alignment of orthologues:
CLUSTAL format alignment by MAFFT L-INS-i (v7.307)

N315            MEFLSLVIVVLAAFLTPIIVNRLNINFLPVVVAEILMGIVIGNSFLNIVERDSILNILST
NCTC8325        MEFLSLVIVVLAAFLTPIIVNRLNINFLPVVVAEILMGIVIGNSFLNIVERDSILNILST
Newman          MEFLSLVIVVLAAFLTPIIVNRLNINFLPVVVAEILMGIVIGNSFLNIVERDSILNILST
USA300_FPR3757  MEFLSLVIVVLAAFLTPIIVNRLNINFLPVVVAEILMGIVIGNSFLNIVERDSILNILST
                ************************************************************

N315            LGFIFLMFLSGLEIDFKAFKKDKRARQGQNDDESSIPGHLNLALTVFAFIMIISILLAYV
NCTC8325        LGFIFLMFLSGLEIDFKAFKKDKRARQGQNDDESSIPGHLNLALTVFAFIMIISILLAYV
Newman          LGFIFLMFLSGLEIDFKAFKKDKRARQGQNDDESSIPGHLNLALTVFAFIMIISILLAYV
USA300_FPR3757  LGFIFLMFLSGLEIDFKAFKKDKRARQGQNDDESSIPGHLNLALTVFAFIMIISILLAYV
                ************************************************************

N315            FKWLGLVDDVLLMVIIISTISLGVVVPTLKEMNIMRTTIGQFILLVAVLADLVTMILLTV
NCTC8325        FKWLGLVDDVLLMVIIISTISLGVVVPTLKEMNIMRTTIGQFILLVAVLADLVTMILLTV
Newman          FKWLGLVDDVLLMVIIISTISLGVVVPTLKEMNIMRTTIGQFILLVAVLADLVTMILLTV
USA300_FPR3757  FKWLGLVDDVLLMVIIISTISLGVVVPTLKEMNIMRTTIGQFILLVAVLADLVTMILLTV
                ************************************************************

N315            YGAINGQGGSTIWLIGILVVFTAISYILGVQFKRMSFLQKLMDGTTQIGIRAVFALIILL
NCTC8325        YGAINGQGGSTIWLIGILVVFTAISYILGVQFKRMSFLQKLMDGTTQIGIRAVFALIILL
Newman          YGAINGQGGSTIWLIGILVVFTAISYILGVQFKRMSFLQKLMDGTTQIGIRAVFALIILL
USA300_FPR3757  YGAINGQGGSTIWLIGILVVFTAISYILGVQFKRMSFLQKLMDGTTQIGIRAVFALIILL
                ************************************************************

N315            VALAEGVGAENILGAFLAGVVVSLLNPDEEMVEKLDSFGYGFFIPIFFIMVGVDLNIPSL
NCTC8325        VALAEGVGAENILGAFLAGVVVSLLNPDEEMVEKLDSFGYGFFIPIFFIMVGVDLNIPSL
Newman          VALAEGVGAENILGAFLAGVVVSLLNPDEEMVEKLDSFGYGFFIPIFFIMVGVDLNIPSL
USA300_FPR3757  VALAEGVGAENILGAFLAGVVVSLLNPDEEMVEKLDSFGYGFFIPIFFIMVGVDLNIPSL
                ************************************************************

N315            IKEPKLLIIIPILIVAFIISKLIPVMFIRRWFDMKTTIASAFLLTSTLSLVIAAAKISER
NCTC8325        IKEPKLLIIIPILIVAFIISKLIPVMFIRRWFDMKTTIASAFLLTSTLSLVIAAAKISER
Newman          IKEPKLLIIIPILIVAFIISKLIPVMFIRRWFDMKTTIASAFLLTSTLSLVIAAAKISER
USA300_FPR3757  IKEPKLLIIIPILIVAFIISKLIPVMFIRRWFDMKTTIASAFLLTSTLSLVIAAAKISER
                ************************************************************

N315            LNAISAETSGILILSAVITCVFVPIIFKKLFPVPDEFNRKIEVSLIGKNQLTIPIAQNLT
NCTC8325        LNAISAETSGILILSAVITCVFVPIIFKKLFPVPDEFNRKIEVSLIGKNQLTIPIAQNLT
Newman          LNAISAETSGILILSAVITCVFVPIIFKKLFPVPDEFNRKIEVSLIGKNQLTIPIAQNLT
USA300_FPR3757  LNAISAETSGILILSAVITCVFVPIIFKKLFPVPDEFNRKIEVSLIGKNQLTIPIAQNLT
                ************************************************************

N315            SQLYDVTLYYRKDLSDRRQLSDDITMIEIADYEQDVLERLGLFDRDIVVCATNDDDINRK
NCTC8325        SQLYDVTLYYRKDLSDRRQLSDDITMIEIADYEQDVLERLGLFDRDIVVCATNDDDINRK
Newman          SQLYDVTLYYRKDLSDRRQLSDDITMIEIADYEQDVLERLGLFDRDIVVCATNDDDINRK
USA300_FPR3757  SQLYDVTLYYRKDLSDRRQLSDDITMIEIADYEQDVLERLGLFDRDIVVCATNDDDINRK
                ************************************************************

N315            VAKLAKAHQVERVICRLESTTDDTELVDSGIEIFSSYLSNKILLKGLIETPNMLNLLSNV
NCTC8325        VAKLAKAHQVERVICRLESTTDDTELVDSGIEIFSSYLSNKILLKGLIETPNMLNLLSNV
Newman          VAKLAKAHQVERVICRLESTTDDTELVDSGIEIFSSYLSNKILLKGLIETPNMLNLLSNV
USA300_FPR3757  VAKLAKAHQVERVICRLESTTDDTELVDSGIEIFSSYLSNKILLKGLIETPNMLNLLSNV
                ************************************************************

N315            ETSLYEIQMLNYKYENIQLRNFPFGGDIIFVRIIRNNESIVPHGDTQLRYGDRLIVTGAK
NCTC8325        ETSLYEIQMLNYKYENIQLRNFPFGGDIIFVRIIRNNESIVPHGDTQLRYGDRLIVTGAK
Newman          ETSLYEIQMLNYKYENIQLRNFPFGGDIIFVRIIRNNESIVPHGDTQLRYGDRLIVTGAK
USA300_FPR3757  ETSLYEIQMLNYKYENIQLRNFPFGGDIIFVRIIRNNESIVPHGDTQLRYGDRLIVTGAK
                ************************************************************

N315            EYVDELKQELEFYF
NCTC8325        EYVDELKQELEFYF
Newman          EYVDELKQELEFYF
USA300_FPR3757  EYVDELKQELEFYF
                **************

↑ Rebecca M Corrigan, Ivan Campeotto, Tharshika Jeganathan, Kevin G Roelofs, Vincent T Lee, Angelika Gründling
Systematic identification of conserved bacterial c-di-AMP receptor proteins.
Proc Natl Acad Sci U S A: 2013, 110(22);9084-9
[PubMed:23671116] [WorldCat.org] [DOI] (I p)Ko-Hsin Chin, Juin-Ming Liang, Jauo-Guey Yang, Min-Shao Shih, Zhi-Le Tu, Yu-Chuang Wang, Xing-Han Sun, Nien-Jen Hu, Zhao-Xun Liang, J Maxwell Dow, Robert P Ryan, Shan-Ho Chou
Structural Insights into the Distinct Binding Mode of Cyclic Di-AMP with SaCpaA_RCK.
Biochemistry: 2015, 54(31);4936-51
[PubMed:26171638] [WorldCat.org] [DOI] (I p)

[1] Rebecca M Corrigan, Ivan Campeotto, Tharshika Jeganathan, Kevin G Roelofs, Vincent T Lee, Angelika Gründling
Systematic identification of conserved bacterial c-di-AMP receptor proteins.
Proc Natl Acad Sci U S A: 2013, 110(22);9084-9
[PubMed:23671116] [WorldCat.org] [DOI] (I p)Ko-Hsin Chin, Juin-Ming Liang, Jauo-Guey Yang, Min-Shao Shih, Zhi-Le Tu, Yu-Chuang Wang, Xing-Han Sun, Nien-Jen Hu, Zhao-Xun Liang, J Maxwell Dow, Robert P Ryan, Shan-Ho Chou
Structural Insights into the Distinct Binding Mode of Cyclic Di-AMP with SaCpaA_RCK.
Biochemistry: 2015, 54(31);4936-51
[PubMed:26171638] [WorldCat.org] [DOI] (I p)

[1]

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Contents

⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

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⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]