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⊟Summary[edit | edit source]
- pan ID?: SAUPAN003177000
- symbol?: relQ
- synonym:
- description?: GTP pyrophosphokinase
- GTP pyrophosphokinase
- GTP pyrophosphokinase family protein
- GTP pyrophosphokinase RelA1
- GTP diphosphokinase
- GTP pyrophosphokinase yjbM
- region found in RelA / SpoT proteins family protein
- RelA/SpoT domain-containing protein
- RelA/SpoT family protein
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 3567899..3568534
- synteny block?: BlockID0022640
- occurrence?: in 100% of 34 strains
relQ: inducible stringent response alarmone pyrophosphokinase [1]
The stringent response alarmones pGpp, ppGpp and pppGpp are synthesized from GTP by rel, relP and relQ. RelP appears to provide a consistent level of basal alarmone production which is degraded by rel's alarmone hydrolase activity. Alarmones allosterically repress alarmone synthesis by RelP. In contrast, RelQ appears to be transcriptionally inducible and alarmones allosterically induce alarmone production resulting in positive-feedback alarmone signal amplification.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0960
08BA02176:
C248_1028
11819-97:
MS7_0961 (yjbM)
6850:
RSAU_000884 (relA1)
71193:
ST398NM01_1001
ECT-R 2:
ECTR2_860
ED133:
SAOV_0951
ED98:
SAAV_0968 (relA1)
HO 5096 0412:
SAEMRSA15_08360
JH1:
SaurJH1_1023
JH9:
SaurJH9_1004
JKD6008:
SAA6008_00959
JKD6159:
SAA6159_00862
JSNZ:
JSNZ_000965
LGA251:
SARLGA251_09210
M013:
M013TW_0928
MRSA252:
SAR0973
MSHR1132:
SAMSHR1132_08530
MSSA476:
SAS0875
Mu3:
SAHV_1000
Mu50:
SAV1006
MW2:
MW0887
RF122:
SAB0872
ST398:
SAPIG1001
T0131:
SAT0131_01041 (pyrG)
TCH60:
HMPREF0772_12231 (relA2)
TW20:
SATW20_10030
USA300_TCH1516:
USA300HOU_0963 (relA1)
VC40:
SAVC_04195
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MNQWDQFLTPYKQAVDELKVKLKGMRKQYEVGEQASPIEFVTGRVKPIASIIDKANKRQI
N315 MNQWDQFLTPYKQAVDELKVKLKGMRKQYEVGEQASPIEFVTGRVKPIASIIDKANKRQI
NCTC8325 MNQWDQFLTPYKQAVDELKVKLKGMRKQYEVGEQASPIEFVTGRVKPIASIIDKANKRQI
Newman MNQWDQFLTPYKQAVDELKVKLKGMRKQYEVGEQASPIEFVTGRVKPIASIIDKANKRQI
USA300_FPR3757 MNQWDQFLTPYKQAVDELKVKLKGMRKQYEVGEQASPIEFVTGRVKPIASIIDKANKRQI
************************************************************
COL PFDRLREEMYDIAGLRMMCQFVEDIDVVVNILRQRKDFKVIEERDYIRNTKESGYRSYHV
N315 PFDRLREEMYDIAGLRMMCQFVEDIDVVVNILRQRKDFKVIEERDYIRNTKESGYRSYHV
NCTC8325 PFDRLREEMYDIAGLRMMCQFVEDIDVVVNILRQRKDFKVIEERDYIRNTKESGYRSYHV
Newman PFDRLREEMYDIAGLRMMCQFVEDIDVVVNILRQRKDFKVIEERDYIRNTKESGYRSYHV
USA300_FPR3757 PFDRLREEMYDIAGLRMMCQFVEDIDVVVNILRQRKDFKVIEERDYIRNTKESGYRSYHV
************************************************************
COL IIEYPIETLQGQKFILAEIQIRTLAMNFWATIEHTLRYKYDGAYPDEIQHRLERAAEAAY
N315 IIEYPIETLQGQKFILAEIQIRTLAMNFWATIEHTLRYKYDGAYPDEIQHRLERAAEAAY
NCTC8325 IIEYPIETLQGQKFILAEIQIRTLAMNFWATIEHTLRYKYDGAYPDEIQHRLERAAEAAY
Newman IIEYPIETLQGQKFILAEIQIRTLAMNFWATIEHTLRYKYDGAYPDEIQHRLERAAEAAY
USA300_FPR3757 IIEYPIETLQGQKFILAEIQIRTLAMNFWATIEHTLRYKYDGAYPDEIQHRLERAAEAAY
************************************************************
COL LLDEEMSEIKDEIQEAQKYYTQKRSKKHEND
N315 LLDEEMSEIKDEIQEAQKYYTQKRSKKHEND
NCTC8325 LLDEEMSEIKDEIQEAQKYYTQKRSKKHEND
Newman LLDEEMSEIKDEIQEAQKYYTQKRSKKHEND
USA300_FPR3757 LLDEEMSEIKDEIQEAQKYYTQKRSKKHEND
*******************************
- ↑ Melek Cemre Manav, Jelena Beljantseva, Martin S Bojer, Tanel Tenson, Hanne Ingmer, Vasili Hauryliuk, Ditlev E Brodersen
Structural basis for (p)ppGpp synthesis by the Staphylococcus aureus small alarmone synthetase RelP.
J Biol Chem: 2018, 293(9);3254-3264
[PubMed:29326162] [WorldCat.org] [DOI] (I p)Ning Yang, Shujie Xie, Nga-Yeung Tang, Mei Yee Choi, Ying Wang, Rory M Watt
The Ps and Qs of alarmone synthesis in Staphylococcus aureus.
PLoS One: 2019, 14(10);e0213630
[PubMed:31613897] [WorldCat.org] [DOI] (I e)Andrea Salzer, Daniela Keinhörster, Christina Kästle, Benjamin Kästle, Christiane Wolz
Small Alarmone Synthetases RelP and RelQ of Staphylococcus aureus Are Involved in Biofilm Formation and Maintenance Under Cell Wall Stress Conditions.
Front Microbiol: 2020, 11;575882
[PubMed:33072039] [WorldCat.org] [DOI] (P e)