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NCBI: 06-JUL-2013
⊟Summary[edit | edit source]
- organism: Staphylococcus aureus Newman
- locus tag: NWMN_0876 [new locus tag: NWMN_RS04910 ]
- pan locus tag?: SAUPAN003177000
- symbol: NWMN_0876
- pan gene symbol?: relQ
- synonym:
- product: GTP pyrophosphokinase
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: NWMN_0876 [new locus tag: NWMN_RS04910 ]
- symbol: NWMN_0876
- product: GTP pyrophosphokinase
- replicon: chromosome
- strand: +
- coordinates: 970965..971600
- length: 636
- essential: unknown other strains
⊟Accession numbers[edit | edit source]
- Gene ID: 5330519 NCBI
- RefSeq: YP_001331910 NCBI
- BioCyc:
- MicrobesOnline: 3706425 MicrobesOnline
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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601ATGAATCAATGGGATCAGTTCTTAACACCTTATAAGCAAGCGGTTGATGAGTTGAAAGTG
AAACTTAAAGGCATGCGCAAACAATATGAAGTTGGTGAACAAGCGTCGCCAATAGAATTT
GTTACTGGTCGTGTTAAACCAATCGCTAGTATTATAGATAAGGCAAACAAACGACAAATA
CCATTTGATAGGTTAAGAGAAGAAATGTACGATATCGCTGGTTTAAGAATGATGTGCCAA
TTTGTTGAAGATATTGATGTTGTCGTCAATATTTTAAGACAAAGAAAAGATTTTAAAGTA
ATTGAAGAACGAGATTATATTCGTAACACTAAAGAAAGTGGTTACCGCTCGTATCATGTC
ATTATTGAATATCCAATTGAAACATTACAAGGCCAAAAATTTATATTGGCTGAGATTCAG
ATTCGTACATTAGCAATGAATTTCTGGGCAACGATTGAACATACTTTACGATATAAATAT
GATGGTGCTTATCCGGATGAAATTCAACATCGTTTGGAAAGAGCGGCAGAAGCAGCGTAT
TTACTTGATGAAGAGATGTCTGAAATTAAAGATGAAATTCAGGAAGCTCAAAAATATTAC
ACGCAAAAACGTTCTAAAAAACATGAAAATGATTAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: NWMN_0876 [new locus tag: NWMN_RS04910 ]
- symbol: NWMN_0876
- description: GTP pyrophosphokinase
- length: 211
- theoretical pI: 6.16491
- theoretical MW: 25238.7
- GRAVY: -0.72654
⊟Function[edit | edit source]
- TIGRFAM: Cellular processes Adaptations to atypical conditions RelA/SpoT family protein (TIGR00691; HMM-score: 36)
- TheSEED: data available for COL, N315, NCTC8325, USA300_FPR3757
- PFAM: NTP_transf (CL0260) RelA_SpoT; Region found in RelA / SpoT proteins (PF04607; HMM-score: 124.6)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 7.5
- Cytoplasmic Membrane Score: 1.15
- Cellwall Score: 0.62
- Extracellular Score: 0.73
- Internal Helices: 0
- LocateP: Intracellular
- Prediction by SwissProt Classification: Cytoplasmic
- Pathway Prediction: No pathway
- Intracellular possibility: 1
- Signal peptide possibility: -1
- N-terminally Anchored Score: -1
- Predicted Cleavage Site: No CleavageSite
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.003537
- TAT(Tat/SPI): 0.000394
- LIPO(Sec/SPII): 0.000728
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MNQWDQFLTPYKQAVDELKVKLKGMRKQYEVGEQASPIEFVTGRVKPIASIIDKANKRQIPFDRLREEMYDIAGLRMMCQFVEDIDVVVNILRQRKDFKVIEERDYIRNTKESGYRSYHVIIEYPIETLQGQKFILAEIQIRTLAMNFWATIEHTLRYKYDGAYPDEIQHRLERAAEAAYLLDEEMSEIKDEIQEAQKYYTQKRSKKHEND
⊟Experimental data[edit | edit source]
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription pattern[edit | edit source]
- S.aureus Expression Data Browser: data available for NCTC8325
⊟Protein synthesis (provided by Aureolib)[edit | edit source]
⊟Protein stability[edit | edit source]
- half-life: no data available
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You are kindly invited to share additional interesting facts.
⊟Literature[edit | edit source]
⊟References[edit | edit source]
⊟Relevant publications[edit | edit source]
Tobias Geiger, Benjamin Kästle, Fabio Lino Gratani, Christiane Goerke, Christiane Wolz
Two small (p)ppGpp synthases in Staphylococcus aureus mediate tolerance against cell envelope stress conditions.
J Bacteriol: 2014, 196(4);894-902
[PubMed:24336937] [WorldCat.org] [DOI] (I p)