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⊟Summary[edit | edit source]
- pan ID?: SAUPAN003136000
- symbol?: opp3F
- synonym:
- description?: oligopeptide ABC transporter ATP-binding protein
- oligopeptide ABC transporter ATP-binding protein
- peptide ABC transporter ATP-binding protein
- ABC transporter ATP-binding protein
- oligopeptide transport system ATP-binding protein OppF, putative
- Oligopeptide transport ATP-binding protein oppF
- putative oligopeptide transport ATP-bindingprotein
- ABC transporter family protein
- ABC transporter-like protein
- oligopeptide ABC superfamily ATP binding cassette transporter, ABC protein
- oligopeptide ABC superfamily ATP binding cassette transporter, ABC protein, Opp3F
- oligopeptide ABC transporter, ATP-binding protein
- oligopeptide transport ATP-binding protein
- Oligopeptide transport system ATP-binding protein
- oligopeptide transport system ATP-binding protein OppF homologue
- oligopeptide transport system ATP-binding protein OppF-like protein
- pseudogene
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 3519634..3520575
- synteny block?: BlockID0022280
- occurrence?: in 100% of 34 strains
opp3F : oligopeptide ABC transporter ATP-binding subunit F [1]
The oligopeptide permease 3 (opp-3) system is the primary mechanism for staphylococcal uptake of amino acid polymers from 3 to 8 residues from the environment for nutrition. Its expression appears to be induced by tyrosine, although this induction can be competitively inhibited by phenylalanine. Intriguingly, deactivation of the opp-3 system can reduce expression of the staphylococcal extracellular proteases that ultimately provide the oligopeptide substrates for opp-3 transport.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0944 (oppF)
08BA02176:
C248_1012 (oppF)
11819-97:
MS7_0944
6850:
RSAU_000863 (oppF1)
71193:
ST398NM01_0985
ECT-R 2:
ECTR2_844 (oppF)
ED133:
SAOV_0935
ED98:
SAAV_0950 (oppF)
HO 5096 0412:
SAEMRSA15_08180 (oppF)
JH1:
SaurJH1_1007
JH9:
SaurJH9_0988
JKD6008:
SAA6008_00942 (oppF)
JKD6159:
SAA6159_00846 (opp3F)
JSNZ:
JSNZ_000949
LGA251:
SARLGA251_09050 (oppF)
M013:
M013TW_0911
MRSA252:
SAR0952 (oppF)
MSHR1132:
SAMSHR1132_08370
MSSA476:
SAS0859
Mu3:
SAHV_0984 (oppF)
Mu50:
SAV0989 (oppF)
MW2:
MW0871 (oppF)
RF122:
SAB0855 (oppF)
ST398:
SAPIG0985
T0131:
SAT0131_01022 (glyA)
TCH60:
HMPREF0772_12256 (oppF3)
TW20:
SATW20_09870 (oppF)
USA300_TCH1516:
USA300HOU_0947 (oppF1)
VC40:
SAVC_04115
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKNDEVLLSIKNLKQYFNAGKKNEVRAIENISFDIYKGETLGLVGESGCGKSTTGKSIIK
N315 MKNDEVLLSIKNLKQYFNAGKKNEVRAIENISFDIYKGETLGLVGESGCGKSTTGKSIIK
NCTC8325 MKNDEVLLSIKNLKQYFNAGKKNEVRAIENISFDIYKGETLGLVGESGCGKSTTGKSIIK
Newman MKNDEVLLSIKNLKQYFNAGKKNEVRAIENISFDIYKGETLGLVGESGCGKSTTGKSIIK
USA300_FPR3757 MKNDEVLLSIKNLKQYFNAGKKNEVRAIENISFDIYKGETLGLVGESGCGKSTTGKSIIK
************************************************************
COL LNDITSGEILYEGIDIQKIRKRKDLLKFNKKIQMIFQDPYASLNPRLKVMDIVAEGIDIH
N315 LNDITSGEILYEGIDIQKIRKRKDLLKFNKKIQMIFQDPYASLNPRLKVMDIVAEGIDIH
NCTC8325 LNDITSGEILYEGIDIQKIRKRKDLLKFNKKIQMIFQDPYASLNPRLKVMDIVAEGIDIH
Newman LNDITSGEILYEGIDIQKIRKRKDLLKFNKKIQMIFQDPYASLNPRLKVMDIVAEGIDIH
USA300_FPR3757 LNDITSGEILYEGIDIQKIRKRKDLLKFNKKIQMIFQDPYASLNPRLKVMDIVAEGIDIH
************************************************************
COL HLATDKRDRKKRVYDLLETVGLSKEHANRYPHEFSGGQRQRIGIARVLAVEPEFIIADEP
N315 HLATDKRDRKKRVYDLLETVGLSKEHANRYPHEFSGGQRQRIGIARALAVEPEFIIADEP
NCTC8325 HLATDKRDRKKRVYDLLETVGLSKEHANRYPHEFSGGQRQRIGIARALAVEPEFIIADEP
Newman HLATDKRDRKKRVYDLLETVGLSKEHANRYPHEFSGGQRQRIGIARVLAVEPEFIIADEP
USA300_FPR3757 HLATDKRDRKKRVYDLLETVGLSKEHANRYPHEFSGGQRQRIGIARALAVEPEFIIADEP
**********************************************.*************
COL ISALDVSIQAQVVNLLLKLQRERGITFLFIAHDLSMVKYISDRIAVMHFGKIVEIGPAEE
N315 ISALDVSIQAQVVNLLLKLQRERGITFLFIAHDLSMVKYISDRIAVMHFGKIVEIGPAEE
NCTC8325 ISALDVSIQAQVVNLLLKLQRERGITFLFIAHDLSMVKYISDRIAVMHFGKIVEIGPAEE
Newman ISALDVSIQAQVVNLLLKLQRERGITFLFIAHDLSMVKYISDRIAVMHFGKIVEIGPAEE
USA300_FPR3757 ISALDVSIQAQVVNLLLKLQRERGITFLFIAHDLSMVKYISDRIAVMHFGKIVEIGPAEE
************************************************************
COL IYQNPLHDYTKSLLSAIPQPDPESERSRKRFSYIDDEANNHLRQLHEIRPNHFVFSTEEE
N315 IYQNPLHDYTKSLLSAIPQPDPESERSRKRFSYIDDEANNHLRQLHEIRPNHFVFSTEEE
NCTC8325 IYQNPLHDYTKSLLSAIPQPDPESERSRKRFSYIDDEANNHLRQLHEIRPNHFVFSTEEE
Newman IYQNPLHDYTKSLLSAIPQPDPESERSRKRFSYIDDEANNHLRQLHEIRPNHFVFSTEEE
USA300_FPR3757 IYQNPLHDYTKSLLSAIPQPDPESERSRKRFSYIDDEANNHLRQLHEIRPNHFVFSTEEE
************************************************************
COL AAQLRENKLVTQN
N315 AAQLRENKLVTQN
NCTC8325 AAQLRENKLVTQN
Newman AAQLRENKLVTQN
USA300_FPR3757 AAQLRENKLVTQN
*************
- ↑ Aurelia Hiron, Elise Borezée-Durant, Jean-Christophe Piard, Vincent Juillard
Only one of four oligopeptide transport systems mediates nitrogen nutrition in Staphylococcus aureus.
J Bacteriol: 2007, 189(14);5119-29
[PubMed:17496096] [WorldCat.org] [DOI] (P p)Elise Borezée-Durant, Aurelia Hiron, Jean-Christophe Piard, Vincent Juillard
Dual role of the oligopeptide permease Opp3 during growth of Staphylococcus aureus in milk.
Appl Environ Microbiol: 2009, 75(10);3355-7
[PubMed:19286789] [WorldCat.org] [DOI] (I p)McKenzie K Lehman, Austin S Nuxoll, Kelsey J Yamada, Tammy Kielian, Steven D Carson, Paul D Fey
Protease-Mediated Growth of Staphylococcus aureus on Host Proteins Is opp3 Dependent.
mBio: 2019, 10(2);
[PubMed:31040245] [WorldCat.org] [DOI] (I e) Imran Khan, Sandy J MacDonald, Sigurbjorn Markusson et al. Distinct roles for the Staphylococcus aureus POT transporter DtpT in di/tripeptide uptake and glutathione utilisation inside human macrophages. Epub ahead of print. BioRxiv. doi: https://doi.org/10.1101/2024.12.02.626324