Jump to navigation
Jump to search
⊟Summary[edit | edit source]
- pan ID?: SAUPAN002695000
- symbol?: clpP
- synonym:
- description?: ATP-dependent Clp protease proteolytic subunit
- ATP-dependent Clp protease proteolytic subunit
- ATP-dependent Clp endopeptidase proteolytic subunit ClpP
- ATP-dependent Clp protease, proteolytic subunit ClpP
- ATP-dependent endopeptidase clp proteolytic subunit
- putative ATP-dependent Clp protease proteolyticsubunit
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 3187331..3187918
- synteny block?: BlockID0019270
- occurrence?: in 100% of 34 strains
clpP : clp proteolytic system core protease subunit ClpP [1]
• A crystal structure is available : 9IRM
The ClpP protease is responsible for ATP-dependent proteolysis of misfolded or targeted proteins. Partner chaperones power ClpP proteolysis with their ATPase activity and provide target protein specificity and unfolding activities but are themselves often dependent on allosteric activation by a third "activating protein" partner. ClpP monomers self-organize into two stacked rings of heptamers forming a compact proteolytic barrel.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0746 (clpP)
08BA02176:
C248_0857 (clpP)
11819-97:
MS7_0819 (clpP)
6850:
RSAU_000744 (clpP)
71193:
ST398NM01_0846
ECT-R 2:
ECTR2_719 (clpP)
ED133:
SAOV_0807
ED98:
SAAV_0733 (clpP)
HO 5096 0412:
SAEMRSA15_06940 (clpP)
JH1:
SaurJH1_0809 (clpP)
JH9:
SaurJH9_0793 (clpP)
JKD6008:
SAA6008_00783 (clpP)
JKD6159:
SAA6159_00725 (clpP)
JSNZ:
JSNZ_000742 (clpP)
LGA251:
SARLGA251_07010 (clpP)
M013:
M013TW_0758
MRSA252:
SAR0823 (clpP)
MSHR1132:
SAMSHR1132_07130
MSSA476:
SAS0733 (clpP)
Mu3:
SAHV_0765 (clpP)
Mu50:
SAV0768 (clpP)
MW2:
MW0730 (clpP)
RF122:
SAB0722 (clpP)
ST398:
SAPIG0846 (clpP)
T0131:
SAT0131_00840
TCH60:
HMPREF0772_12412 (clpP)
TW20:
SATW20_08430 (clpP)
USA300_TCH1516:
USA300HOU_0797 (clpP)
VC40:
SAVC_03485 (clpP)
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDI
N315 MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDI
NCTC8325 MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDI
Newman MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDI
USA300_FPR3757 MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDI
************************************************************
COL YLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEV
N315 YLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEV
NCTC8325 YLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEV
Newman YLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEV
USA300_FPR3757 YLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEV
************************************************************
COL MIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEA
N315 MIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEA
NCTC8325 MIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEA
Newman MIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEA
USA300_FPR3757 MIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEA
************************************************************
COL KEYGLIDEVMVPETK
N315 KEYGLIDEVMVPETK
NCTC8325 KEYGLIDEVMVPETK
Newman KEYGLIDEVMVPETK
USA300_FPR3757 KEYGLIDEVMVPETK
***************
- ↑ Astrid Illigmann, Marie-Theres Vielberg, Markus Lakemeyer, Felix Wolf, Taulant Dema, Patrik Stange, Wolfgang Kuttenlochner, Elisa Liebhart, Andreas Kulik, Nicole D Staudt, Imran Malik, Stephanie Grond, Stephan A Sieber, Leonard Kaysser, Michael Groll, Heike Brötz-Oesterhelt
Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A.
Angew Chem Int Ed Engl: 2024, 63(3);e202314028
[PubMed:38029352] [WorldCat.org] [DOI] (I p)Lijuan Xu, Camilla Henriksen, Viktor Mebus, Romain Guérillot, Andreas Petersen, Nicolas Jacques, Jhih-Hang Jiang, Rico J E Derks, Elena Sánchez-López, Martin Giera, Kirsten Leeten, Timothy P Stinear, Cécile Oury, Benjamin P Howden, Anton Y Peleg, Dorte Frees
A Clinically Selected Staphylococcus aureus clpP Mutant Survives Daptomycin Treatment by Reducing Binding of the Antibiotic and Adapting a Rod-Shaped Morphology.
Antimicrob Agents Chemother: 2023, 67(6);e0032823
[PubMed:37184389] [WorldCat.org] [DOI] (I p)Volker C Kirsch, Christian Fetzer, Stephan A Sieber
Global Inventory of ClpP- and ClpX-Regulated Proteins in Staphylococcus aureus.
J Proteome Res: 2021, 20(1);867-879
[PubMed:33210542] [WorldCat.org] [DOI] (I p)