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⊟Summary[edit | edit source]
- pan ID?: SAUPAN002227000
- symbol?: metS
- synonym:
- description?: methionine--tRNA ligase
- methionine--tRNA ligase
- methionyl-tRNA synthetase
- CsaA
- methionyl-tRNA synthetase (Methionine--tRNA ligase)(MetRS)
- putative methionyl-tRNA synthetase
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 2736388..2738361
- synteny block?: BlockID0015260
- occurrence?: in 100% of 34 strains
metRS (metS) : methionyl-tRNA synthetase [1]
• A crystal structure is available: 4QRE
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0465 (metS)
08BA02176:
C248_0545 (metG)
11819-97:
MS7_0467 (metG)
6850:
RSAU_000427 (metS)
71193:
ST398NM01_0556
ECT-R 2:
ECTR2_430 (metG)
ED133:
SAOV_0512 (metS)
ED98:
SAAV_0437 (metS)
HO 5096 0412:
SAEMRSA15_04160 (metG)
JH1:
SaurJH1_0524
JH9:
SaurJH9_0511
JKD6008:
SAA6008_00494 (metS)
JKD6159:
SAA6159_00441 (metS)
JSNZ:
JSNZ_000429 (metG)
LGA251:
SARLGA251_04240 (metG)
M013:
M013TW_0459
MRSA252:
SAR0491 (metG)
MSHR1132:
SAMSHR1132_04340
MSSA476:
SAS0447
Mu3:
SAHV_0487 (metS)
Mu50:
SAV0490 (metS)
MW2:
MW0445 (metS)
RF122:
SAB0439 (metG)
ST398:
SAPIG0556 (metG)
T0131:
SAT0131_00535
TCH60:
HMPREF0772_10030 (metG)
TW20:
SATW20_05580 (metG)
USA300_TCH1516:
USA300HOU_0490 (metS)
VC40:
SAVC_02035
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MAKETFYITTPIYYPSGNLHIGHAYSTVAGDVIARYKRMQGYDVRYLTGTDEHGQKIQEK
N315 MAKETFYITTPIYYPSGNLHIGHAYSTVAGDVIARYKRMQGYDVRYLTGTDEHGQKIQEK
NCTC8325 MAKETFYITTPIYYPSGNLHIGHAYSTVAGDVIARYKRMQGYDVRYLTGTDEHGQKIQEK
Newman MAKETFYITTPIYYPSGNLHIGHAYSTVAGDVIARYKRMQGYDVRYLTGTDEHGQKIQEK
USA300_FPR3757 MAKETFYITTPIYYPSGNLHIGHAYSTVAGDVIARYKRMQGYDVRYLTGTDEHGQKIQEK
************************************************************
COL AQKAGKTEIEYLDEMIAGIKQLWAKLEISNDDFIRTTEERHKHVVEQVFERLLKQGDIYL
N315 AQKAGKTEIEYLDEMIAGIKQLWAKLEISNDDFIRTTEERHKHVVEQVFERLLKQGDIYL
NCTC8325 AQKAGKTEIEYLDEMIAGIKQLWAKLEISNDDFIRTTEERHKHVVEQVFERLLKQGDIYL
Newman AQKAGKTEIEYLDEMIAGIKQLWAKLEISNDDFIRTTEERHKHVVEQVFERLLKQGDIYL
USA300_FPR3757 AQKSGKTEIEYLDEMIAGIKQLWAKLEISNDDFIRTTEERHKHVVEQVFERLLKQGDIYL
***:********************************************************
COL GEYEGWYSVPDETYYTESQLVDPQYENGKIIGGKSPDSGHEVELVKEESYFFNISKYTDR
N315 GEYEGWYSVPDETYYTESQLVDPQYENGKIIGGKSPDSGHEVELVKEESYFFNISKYTDR
NCTC8325 GEYEGWYSVPDETYYTESQLVDPQYENGKIIGGKSPDSGHEVELVKEESYFFNISKYTDR
Newman GEYEGWYSVPDETYYTESQLVDPQYENGKIIGGKSPDSGHEVELVKEESYFFNISKYTDR
USA300_FPR3757 GEYEGWYSVPDETYYTESQLVDPQYENGKIIGGKSPDSGHEVELVKEESYFFNISKYTDR
************************************************************
COL LLEFYDQNPDFIQPPSRKNEMINNFIKPGLADLAVSRTSFNWGVHVPSNPKHVVYVWIDA
N315 LLEFYDQNPDFIQPPSRKNEMINNFIKPGLADLAVSRTSFNWGVHVPSNPKHVVYVWIDA
NCTC8325 LLEFYDQNPDFIQPPSRKNEMINNFIKPGLADLAVSRTSFNWGVHVPSNPKHVVYVWIDA
Newman LLEFYDQNPDFIQPPSRKNEMINNFIKPGLADLAVSRTSFNWGVHVPSNPKHVVYVWIDA
USA300_FPR3757 LLEFYDQNPDFIQPPSRKNEMINNFIKPGLADLAVSRTSFNWGVHVPSNPKHVVYVWIDA
************************************************************
COL LVNYISALGYLSDDESLFNKYWPADIHLMAKEIVRFHSIIWPILLMALDLPLPKKVFAHG
N315 LVNYISALGYLSDDESLFNKYWPADIHLMAKEIVRFHSIIWPILLMALDLPLPKKVFAHG
NCTC8325 LVNYISALGYLSDDESLFNKYWPADIHLMAKEIVRFHSIIWPILLMALDLPLPKKVFAHG
Newman LVNYISALGYLSDDESLFNKYWPADIHLMAKEIVRFHSIIWPILLMALDLPLPKKVFAHG
USA300_FPR3757 LVNYISALGYLSDDESLFNKYWPADIHLMAKEIVRFHSIIWPILLMALDLPLPKKVFAHG
************************************************************
COL WILMKDGKMSKSKGNVVDPNILIDRYGLDATRYYLMRELPFGSDGVFTPEAFVERTNFDL
N315 WILMKDGKMSKSKGNVVDPNILIDRYGLDATRYYLMRELPFGSDGVFTPEAFVERTNFDL
NCTC8325 WILMKDGKMSKSKGNVVDPNILIDRYGLDATRYYLMRELPFGSDGVFTPEAFVERTNFDL
Newman WILMKDGKMSKSKGNVVDPNILIDRYGLDATRYYLMRELPFGSDGVFTPEAFVERTNFDL
USA300_FPR3757 WILMKDGKMSKSKGNVVDPNILIDRYGLDATRYYLMRELPFGSDGVFTPEAFVERTNFDL
************************************************************
COL ANDLGNLVNRTISMVNKYFDGELPAYQGPLHELDEEMEAMALETVKSYTESMESLQFSVA
N315 ANDLGNLVNRTISMVNKYFDGELPAYQGPLHELDEEMEAMALETVKSYTESMESLQFSVA
NCTC8325 ANDLGNLVNRTISMVNKYFDGELPAYQGPLHELDEEMEAMALETVKSYTESMESLQFSVA
Newman ANDLGNLVNRTISMVNKYFDGELPAYQGPLHELDEEMEAMALETVKSYTESMESLQFSVA
USA300_FPR3757 ANDLGNLVNRTISMVNKYFDGELPAYQGPLHELDEEMEAMALETVKSYTESMESLQFSVA
************************************************************
COL LSTVWKFISRTNKYIDETTPWVLAKDDSQKDMLGNVMAHLVENIRYAAVLLRPFLTHAPK
N315 LSTVWKFISRTNKYIDETTPWVLAKDDSQKDMLGNVMAHLVENIRYAAVLLRPFLTHAPK
NCTC8325 LSTVWKFISRTNKYIDETTPWVLAKDDSQKDMLGNVMAHLVENIRYAAVLLRPFLTHAPK
Newman LSTVWKFISRTNKYIDETTPWVLAKDDSQKDMLGNVMAHLVENIRYAAVLLRPFLTHAPK
USA300_FPR3757 LSTVWKFISRTNKYIDETTPWVLAKDDSQKDMLGNVMAHLVENIRYAAVLLRPFLTHAPK
************************************************************
COL EIFEQLNINNPQFMEFSSLEQYGVLNESIMVTGQPKPIFPRLDSEAEIAYIKESMQPPAT
N315 EIFEQLNINNPQFMEFSSLEQYGVLTESIMVTGQPKPIFPRLDSEAEIAYIKESMQPPAT
NCTC8325 EIFEQLNINNPQFMEFSSLEQYGVLNESIMVTGQPKPIFPRLDSEAEIAYIKESMQPPAT
Newman EIFEQLNINNPQFMEFSSLEQYGVLNESIMVTGQPKPIFPRLDSEAEIAYIKESMQPPAT
USA300_FPR3757 EIFEQLNINNPQFMEFSSLEQYGVLNESIMVTGQPKPIFPRLDSEAEIAYIKESMQPPAT
*************************.**********************************
COL KEEKEEIPSKPQIDIKDFDKVEIKAATIIDAEHVKKSDKLLKIQVDLDSEQRQIVSGIAK
N315 EEEKEEIPSKPQIDIKDFDKVEIKAATIIDAEHVKKSDKLLKIQVDLDSEQRQIVSGIAK
NCTC8325 KEEKEEIPSKPQIDIKDFDKVEIKAATIIDAEHVKKSDKLLKIQVDLDSEQRQIVSGIAK
Newman KEEKEEIPSKPQIDIKDFDKVEIKAATIIDAEHVKKSDKLLKIQVDLDSEQRQIVSGIAK
USA300_FPR3757 KEEKEEIPSKPQIDIKDFDKVEIKAATIIDAEHVKKSDKLLKIQVDLDSEQRQIVSGIAK
:***********************************************************
COL FYTPDDIIGKKVAVVTNLKPAKLMGQKSEGMILSAEKDGVLTLVSLPSAIPNGAVIK
N315 FYTPDDIIGKKVAVVTNLKPAKLMGQKSEGMILSAEKDGVLTLVSLPSAIPNGAVIK
NCTC8325 FYTPDDIIGKKVAVVTNLKPAKLMGQKSEGMILSAEKDGVLTLVSLPSAIPNGAVIK
Newman FYTPDDIIGKKVAVVTNLKPAKLMGQKSEGMILSAEKDGVLTLVSLPSAIPNGAVIK
USA300_FPR3757 FYTPDDIIGKKVAVVTNLKPAKLMGQKSEGMILSAEKDGVLTLVSLPSAIPNGAVIK
*********************************************************
- ↑ Feihu Lu, Kaijiang Xia, Jingtian Su, Jia Yi, Zhiteng Luo, Jun Xu, Qiong Gu, Bingyi Chen, Huihao Zhou
Biochemical and structural characterization of chlorhexidine as an ATP-assisted inhibitor against type 1 methionyl-tRNA synthetase from Gram-positive bacteria.
Eur J Med Chem: 2024, 268;116303
[PubMed:38458107] [WorldCat.org] [DOI] (I p)Omeed Faghih, Zhongsheng Zhang, Ranae M Ranade, J Robert Gillespie, Sharon A Creason, Wenlin Huang, Sayaka Shibata, Ximena Barros-Álvarez, Christophe L M J Verlinde, Wim G J Hol, Erkang Fan, Frederick S Buckner
Development of Methionyl-tRNA Synthetase Inhibitors as Antibiotics for Gram-Positive Bacterial Infections.
Antimicrob Agents Chemother: 2017, 61(11);
[PubMed:28848016] [WorldCat.org] [DOI] (I e)John Finn, Mark Stidham, Mark Hilgers, Kedar G C
Identification of novel inhibitors of methionyl-tRNA synthetase (MetRS) by virtual screening.
Bioorg Med Chem Lett: 2008, 18(14);3932-7
[PubMed:18590962] [WorldCat.org] [DOI] (I p)Daniel R Gentry, Karen A Ingraham, Michael J Stanhope, Stephen Rittenhouse, Richard L Jarvest, Peter J O'Hanlon, James R Brown, David J Holmes
Variable sensitivity to bacterial methionyl-tRNA synthetase inhibitors reveals subpopulations of Streptococcus pneumoniae with two distinct methionyl-tRNA synthetase genes.
Antimicrob Agents Chemother: 2003, 47(6);1784-9
[PubMed:12760849] [WorldCat.org] [DOI] (P p)