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Summary[edit | edit source]

  • pan ID?: SAUPAN002146000
  • symbol?:
  • synonym:
  • description?: membrane protein

      descriptions from strain specific annotations:

    • membrane protein
    • lipase family protein
    • pseudogene
  • strand?: +
  • coordinates?: 2653297..2662055
  • synteny block?: BlockID0014520
  • occurrence?: in 85% of 34 strains

tslA : type VIIb-secreted phospholipase toxin TslA [1]

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    JSNZ:
    04-02981:
    SA2981_0422
    08BA02176:
    11819-97:
    MS7_0420
    6850:
    RSAU_000376
    71193:
    ECT-R 2:
    ECTR2_381
    ED133:
    SAOV_0459
    ED98:
    SAAV_0389
    HO 5096 0412:
    SAEMRSA15_03710
    JH1:
    SaurJH1_0481
    JH9:
    SaurJH9_0469
    JKD6008:
    SAA6008_00449
    JKD6159:
    LGA251:
    SARLGA251_03810
    M013:
    M013TW_0409
    MRSA252:
    SAR0446
    MSHR1132:
    MSSA476:
    SAS0404
    Mu3:
    SAHV_0444
    Mu50:
    SAV0446
    MW2:
    MW0402
    RF122:
    SAB0397
    ST398:
    T0131:
    SAT0131_00484
    TCH60:
    HMPREF0772_10076
    TW20:
    SATW20_05150
    USA300_TCH1516:
    USA300HOU_0448
    VC40:
    SAVC_01825

Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757
JSNZ

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.505)


    COL             -MSRKYKIDLKAINQNTESTSAISKASYEVENANNNGLSKRDVINQFNDLKKMKKFPSNL
    N315            -MKDKYKIDPGIIKNNTEETTAISKISYEVENANLYGADSEDITRQIEYLKAKKKFPSNL
    NCTC8325        MLSRKYKIDLKAINQNTESTSAISKASYEVENANNNGLSKRDVINQFNDLKKMKKFPSNL
    Newman          MLSRKYKIDLKAINQNTESTSAISKASYEVENANNNGLSKRDVINQFNDLKKMKKFPSNL
    USA300_FPR3757  MLSRKYKIDLKAINQNTESTSAISKASYEVENANNNGLSKRDVINQFNDLKKMKKFPSNL
    JSNZ            -MSNKFRLDHSFINNKTETTSAVSKLSYEIENANLNGLPKTNLQLQFDRLKVTNEFPSNL
                     :. *:::*   *:::** *:*:** ***:****  *  . ::  *:: **  ::*****

    COL             EYVDSYTDSLTGVTTSAFLNKDTGKVTLGMTGTNLQDEAFKK---LKEGEFSRQNVTNAL
    N315            EYVDSYTDSLNGVTTSAFLNKDTGKVTLGMTGTNIQGEAFKK---LKEGEFSRQNVTNAL
    NCTC8325        EYVDSYTDSLTGVTTSAFLNKDTGKVTLGMTGTNLQDEAFKK---LKEGEFSRQNVTNAL
    Newman          EYVDSYTDSLTGVTTSAFLNKDTGKVTLGMTGTNLQDEAFKK---LKEGEFSRQNVTNAL
    USA300_FPR3757  EYVDSYTDSLTGVTTSAFLNKDTGKVTLGMTGTNLQDEAFKK---LKEGEFSRQNVTNAL
    JSNZ            EYIDSHTDKKYGVTASAFLNKDTGKVIIGMTGTNFKKEALAKQLLLPGFATTKQDKIDSA
                    **:**:**.  ***:*********** :******:: **: *   *     ::*:  :: 

    COL             ETVKDGYADLKILYSPASDQNYRYANTQEFINKIKSKYDIDFITGHSLGGRDAVVLGMSN
    N315            ETVKDGYADLKILYSPASDQNYRYANTQEFINKIKSKYDIDFITGHSLGGRDAVVLGMSN
    NCTC8325        ETVKDGYADLKILYSPASDQNYRYANTQEFINKIKSKYDIDFITGHSLGGRDAVVLGMSN
    Newman          ETVKDGYADLKILYSPASDQNYRYANTQEFINKIKSKYDIDFITGHSLGGRDAVVLGMSN
    USA300_FPR3757  ETVKDGYADLKILYSPASDQNYRYANTQEFINKIKSKYDIDFITGHSLGGRDAVVLGMSN
    JSNZ            ETRKDLISDVQIGTFPPSDKSKHYEETQEFIKKIKNKYDIDFITGHSLGGREAVILGMSN
                    ** **  :*::*   *.**:. :* :*****:***.***************:**:*****

    COL             GIPNIVVYNPAPISITSLNPNSPDGKRLLELYKNYKGNITRFVAENDALTENLKKYKHYV
    N315            GIPNIVVYNPAPISINSLNPNSPDGKRLLELYKNYKGNITRFVAENDALTENLKKYKHYV
    NCTC8325        GIPNIVVYNPAPISITSLNPNSPDGKRLLELYKNYKGNITRFVAENDALTENLKKYKHYV
    Newman          GIPNIVVYNPAPISITSLNPNSPDGKRLLELYKNYKGNITRFVAENDALTENLKKYKHYV
    USA300_FPR3757  GIPNIVVYNPAPISITSLNPNSPDGKRLLELYKNYKGNITRFVAENDALTENLKKYKHYV
    JSNZ            GIPNIVVYNPAPISAIGLDPNS----RLFKLYKGYKGNITRVVSNKDELTNFIQGYTKYV
                    **************  .*:***    **::***.*******.*:::* **: :: *.:**

    COL             FFGNDKVFKNGKGHEMEGFLTEEEQKAIKKELKKLQGYAEENNKSFVKNSNNAISKLASI
    N315            FFGNDKVFKNGKGHEMEGFLTEEEQKAIKKELKKLQGYAEENNKSFVKNSNNAISKLASI
    NCTC8325        FFGNDKVFKNGKGHEMEGFLTEEEQKAIKKELKKLQGYAEENNKSFVKNSNNAISKLASI
    Newman          FFGNDKVFKNGKGHEMEGFLTEEEQKAIKKELKKLQGYAEENNKSFVKNSNNAISKLASI
    USA300_FPR3757  FFGNDKVFKNGKGHEMEGFLTEEEQKAIKKELKKLQGYAEENNKSFVKNSNNAISKLASI
    JSNZ            YFGHEIVIENGKGHSMDGFLTEQEQKAIKKELKKLQGYVEENNKSFVKHSNNAISKLASI
                    :**:: *::*****.*:*****:***************.*********:***********

    COL             ELLRANMMTTNGGGLSSSQQKVLESLTALTIAQSFSQLIDDEINQIKKMYNEKKKKFGKN
    N315            ELLRANMMTTNGGGLSSSQQKVLESLTALTIAQSFSQLIDDEINQIKKMYNEKKKEFGKN
    NCTC8325        ELLRANMMTTNGGGLSSSQQKVLESLTALTIAQSFSQLIDDEINQIKKMYNEKKKKFGKN
    Newman          ELLRANMMTTNGGGLSSSQQKVLESLTALTIAQSFSQLIDDEINQIKKMYNEKKKKFGKN
    USA300_FPR3757  ELLRANMMTTNGGGLSSSQQKVLESLTALTIAQSFSQLIDDEINQIKKMYNEKKKKFGKN
    JSNZ            ELLRTNMMTTNGGWLSSSQQKALESLSALTIAQSFSQLIDDEINQIKKMYNEKEKKFEKN
                    ****:******** *******.****:**************************:*:* **

    COL             WEDAQKAGKAVGEDLSVNGVLNALDEGQVNESSMVREPEQMISAKERQLSTIGSSVSNYI
    N315            WEDAQKAGKAVGEDLSVNGVLNALDEGQVNESSMVREPEQMISAKERQLSTIGSSVSNYI
    NCTC8325        WEDAQKAGKAVGEDLSVNGVLNALDEGQVNESSMVREPEQMISAKERQLSTIGSSVSNYI
    Newman          WEDAQKAGKAVGEDLSVNGVLNALDEGQVNESSMVREPEQMISAKERQLSTIGSSVSNYI
    USA300_FPR3757  WEDAQKAGKAVGEDLSVNGVLNALDEGQVNESSMVREPEQMISAKERQLSTIGSSVSNYI
    JSNZ            WEDAQKAGNAVGKDITVSEVLEALDEGHVNESSMVGDPEQMISAKERQLSTIGSSVSNYI
                    ********:***:*::*. **:*****:******* :***********************

    COL             MRVRLSINEIVDKDQVLASQIGGLL
    N315            MRVRLSINEIVDKDQVLASQIGGLL
    NCTC8325        MRVRLSINEIVDKDQVLASQIGGLL
    Newman          MRVRLSINEIVDKDQVLASQIGGLL
    USA300_FPR3757  MRVRLSINEIVDKDQVLASQIGGLL
    JSNZ            LRVRSSINEIVDKDQVLASQIGGLL
                    :*** ********************

  1. Stephen R Garrett, Nicole Mietrach, Justin Deme, Alina Bitzer, Yaping Yang, Fatima R Ulhuq, Dorothee Kretschmer, Simon Heilbronner, Terry K Smith, Susan M Lea, Tracy Palmer
    A type VII-secreted lipase toxin with reverse domain arrangement.
    Nat Commun: 2023, 14(1);8438
    [PubMed:38114483] [WorldCat.org] [DOI] (I e)