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⊟Summary[edit | edit source]
- pan ID?: SAUPAN002145000
- symbol?: lpl8
- synonym:
- description?: tandem-type lipoprotein
- tandem-type lipoprotein
- tandem lipoprotein
- lipoprotein, putative
- putative lipoprotein
- staphylococcal tandem lipoprotein
- staphylococcus tandem lipoproteins family protein
- Tandem lipoprotein within Pathogenicity island
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 2649037..2651842
- synteny block?: BlockID0014510
- occurrence?: in 62% of 34 strains
tilA (lpl) : tandem TslA phospholipase immunity lipoprotein paralogue [1]
• This locus is highly prone to recombination leading to gene duplication / loss. Gene nomenclature is confusing and appears to be numbered sequentially by position in the genome and is not intended to show homology between strains (e.g. the first instance of tilA/lpl in COL may have the greatest homology with the sixth instance in FPR3757 but the gene names would still be different [i.e. tilA1/lpl1 and tilA6/lpl6 in COL and FPR3757, respectively]). Likewise, pseudogenes are frequent and assigned gene nomenclature in this locus. As appropriate, please append a numeral to the gene names provided here consistent with the number of gene duplications in your genome of interest.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0420 (lpl8)
08BA02176:
—
11819-97:
—
6850:
RSAU_000369
71193:
—
ECT-R 2:
ECTR2_379
ED133:
SAOV_0457
ED98:
SAAV_0387
HO 5096 0412:
—
JH1:
SaurJH1_0479
JH9:
SaurJH9_0467
JKD6008:
SAA6008_00447 (lpl8_1)
JKD6159:
—
JSNZ:
—
LGA251:
—
M013:
—
MRSA252:
SAR0444
MSHR1132:
—
MSSA476:
—
Mu3:
SAHV_0442 (lpl8)
Mu50:
SAV0444 (lpl8)
MW2:
—
RF122:
—
ST398:
—
T0131:
SAT0131_00482
TCH60:
HMPREF0772_10078
TW20:
SATW20_05130
USA300_TCH1516:
USA300HOU_0446
VC40:
SAVC_01815
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKSIKRIGLCISLLILIIFVTSCDGDNKIIGDSKEEQIKKSFAKTLDIYPIKNLEDLYDK
N315 MKSIKRIGLCISLLILIIFATSC-GSNKITGDSKEEQIKKSFAKSLDKYPTENLEEFYDK
NCTC8325 MKSIKRIGLCISLLILIIFVTSCDGDNKIIGDSKEEQIKKSFAKTLDIYPIKNLEDLYDK
Newman MKSIKRIGLCISLLILIIFVTSCDGDNKIIGDSKEEQIKKSFAKTLDIYPIKNLEDLYDK
USA300_FPR3757 MKSIKRIGLCISLLILIIFVTSCDGDNKIIGDSKEEQIKKSFAKTLDIYPIKNLEDLYDK
*******************.*** *.*** **************:** ** :***::***
COL EGYRDGEFKKDDKGTWLIRSEMKIQLKGENLESRGAVLEINRNTRTAKGHYIVREVVEDS
N315 EGYRDGEFEKDDKGTWLIRSEMKIQLKGENLESRGAVIEINRNTRTAKGNYIVREVVEDS
NCTC8325 EGYRDGEFKKDDKGTWLIRSEMKIQLKGENLESRGAVLEINRNTRTAKGHYIVREVVEDS
Newman EGYRDGEFKKDDKGTWLIRSEMKIQLKGENLESRGAVLEINRNTRTAKGHYIVREVVEDS
USA300_FPR3757 EGYRDGEFKKDDKGTWLIRSEMKIQLKGENLESRGAVLEINRNTRTAKGHYIVREVVEDS
********:****************************:***********:**********
COL DGMTHNHTKRYPVKMENNKMIPLKPIDDEKVKKEIEEFNFFVQYGNFKELENYKEDEVSY
N315 DGMTHNHTKRYPVKMENNKMIPLKSIDDEKVKKEIEEFKFFVQYGNFKELENYKEDEVSY
NCTC8325 DGMTHNHTKRYPVKMENNKMIPLKPIDDEKVKKEIEEFNFFVQYGNFKELENYKEDEVSY
Newman DGMTHNHTKRYPVKMENNKMIPLKPIDDEKVKKEIEEFNFFVQYGNFKELENYKEDEVSY
USA300_FPR3757 DGMTHNHTKRYPVKMENNKMIPLKPIDDEKVKKEIEEFNFFVQYGNFKELENYKEDEVSY
************************.*************:*********************
COL NPEVPIYSAKYQLKNSDYNVEQLRKRYNIPTQKAPKLLLKGSGNLKGSSVGYKNIEFTFI
N315 NPEVPIYSAQYQLKNSDYNVEQLRKRYNIPTQKAPKLLLKGSGNLKGSSVGYKNIEFTFV
NCTC8325 NPEVPIYSAKYQLKNSDYNVEQLRKRYNIPTQKAPKLLLKGSGNLKGSSVGYKNIEFTFI
Newman NPEVPIYSAKYQLKNSDYNVEQLRKRYNIPTQKAPKLLLKGSGNLKGSSVGYKNIEFTFI
USA300_FPR3757 NPEVPIYSAKYQLKNSDYNVEQLRKRYNIPTQKAPKLLLKGSGNLKGSSVGYKNIEFTFI
*********:*************************************************:
COL ENKEENIYFTDSIYFNPSEDK
N315 ENKEENIYFTDSVYFNPSEDK
NCTC8325 ENKEENIYFTDSIYFNPSEDK
Newman ENKEENIYFTDSIYFNPSEDK
USA300_FPR3757 ENKEENIYFTDSIYFNPSEDK
************:********
- ↑ Stephen R Garrett, Nicole Mietrach, Justin Deme, Alina Bitzer, Yaping Yang, Fatima R Ulhuq, Dorothee Kretschmer, Simon Heilbronner, Terry K Smith, Susan M Lea, Tracy Palmer
A type VII-secreted lipase toxin with reverse domain arrangement.
Nat Commun: 2023, 14(1);8438
[PubMed:38114483] [WorldCat.org] [DOI] (I e)Stephen R Garrett, Giuseppina Mariano, Jo Dicks, Tracy Palmer
Homologous recombination between tandem paralogues drives evolution of a subset of type VII secretion system immunity genes in firmicute bacteria.
Microb Genom: 2022, 8(8);
[PubMed:35960642] [WorldCat.org] [DOI] (I p)