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PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159JSNZLGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40
⊟Summary[edit | edit source]
- pan ID?: SAUPAN002139000
- symbol?: lpl5
- synonym:
- description?: tandem-type lipoprotein
- tandem-type lipoprotein
- tandem lipoprotein
- staphylococcal tandem lipoprotein
- putative lipoprotein
- staphylococcus tandem lipoproteins family protein
- Tandem lipoprotein within Pathogenicity island 2
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 2642051..2642846
- synteny block?: BlockID0014450
- occurrence?: in 41% of 34 strains
tilA (lpl) : tandem TslA phospholipase immunity lipoprotein paralogue [1]
• This locus is highly prone to recombination leading to gene duplication / loss. Gene nomenclature is confusing and appears to be numbered sequentially by position in the genome and is not intended to show homology between strains (e.g. the first instance of tilA/lpl in COL may have the greatest homology with the sixth instance in FPR3757 but the gene names would still be different [i.e. tilA1/lpl1 and tilA6/lpl6 in COL and FPR3757, respectively]). Likewise, pseudogenes are frequent and assigned gene nomenclature in this locus. As appropriate, please append a numeral to the gene names provided here consistent with the number of gene duplications in your genome of interest.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0414 (lpl3)
08BA02176:
—
11819-97:
—
6850:
RSAU_000373
71193:
—
ECT-R 2:
ECTR2_373
ED133:
—
ED98:
SAAV_0381
HO 5096 0412:
SAEMRSA15_03700
JH1:
SaurJH1_0473
JH9:
SaurJH9_0461
JKD6008:
—
JKD6159:
—
JSNZ:
—
LGA251:
—
M013:
—
MRSA252:
—
MSHR1132:
—
MSSA476:
—
Mu3:
SAHV_0436 (lpl3)
Mu50:
SAV0438 (lpl3)
MW2:
—
RF122:
—
ST398:
—
T0131:
—
TCH60:
—
TW20:
—
USA300_TCH1516:
USA300HOU_0443
VC40:
—
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL -MEYLKRLALLISVIILTIFIMGCDSQSDTAENPKEGSKEAQIKKSFSKTLDMYPIKNLE
N315 MMGYSKRFALYISVMILIFAIAGCGKSDET----KEGSKEEQIKKSFAKTLDMYPIKNLE
Newman -MEYLKRLALLISVIILTIFIMGCDSQSDTAENPKEGSKEAQIKKSFSKTLDMYPIKNLE
USA300_FPR3757 -MEYLKRLALLISVIILTIFIMGCDSQSDTAENPKEGSKEAQIKKSFSKTLDMYPIKNLE
* * **:** ***:** : * **....:* ****** ******:************
COL DFYDKEGYRDGEFKKDDKGTWLIRSEIVKQPKGKVMKTRGMQLYINRNTETAKGFFVLKE
N315 DLYDKEGYRDGEFKKGDKGTWVISSVMVKQPKGEIMKSRGMYLFLNRNTRTAKGYFIVDE
Newman DFYDKEGYRDGEFKKDDKGTWLIRSEIVKQPKGKVMKTRGMQLYINRNTETAKGFFVLKE
USA300_FPR3757 DFYGKEGYRDGEFKKDDKGTWLIRSEIVKQPKGKVMKTRGMQLYINRNTETAKGFFVLKE
*:*.***********.*****:* * :******::**:*** *::****.****:*::.*
COL ISENNNRVNKDKEEKYEVKMVGNKIIPTEQINDEKIKKEIENFKFFVQYGNFKNFEKYNN
N315 TSNDTLKKTEDKEKRYPVKMVNNKIVPIDPINDKGVKKEIENFKFFSQYGDFKELKNYKN
Newman ISENNNRVNKDKEEKYEVKMVGNKIIPTEQINDEKIKKEIENFKFFVQYGNFKNFEKYNN
USA300_FPR3757 ISENNNRVNKDKEEKYEVKMVGNKIIPTEQINDEKIKKEIENFKFFVQYGNFKNFEKYNN
*::. : .:***::* ****.***:* : ***: :********** ***:**::::*:*
COL GEFSYNPEAPIYSAKYQLHNDDYNVRQLRKRYDISTKETPKLLLKGGGDLKNSSVGQNDI
N315 GEVSYNSEAPIYSAKYQLKNNDYNVKQLRKRYDISTEKAPKLLLKGTGDLKGSSIGHKDI
Newman GEFSYNPEAPIYSAKYQLHNDDYNVRQLRKRYDISTKETPKLLLKGGGDLKNSSVGQNDI
USA300_FPR3757 GEFSYNPEAPIYSAKYQLHNDDYNVRQLRKRYDISTKETPKLLLKGGGDLKNSSVGQNDI
**.***.***********:*:****:**********:::******* ****.**:*::**
COL EFTFVERKGENIYFNDSVEFIPSK--
N315 EFTFVENQEENIFFTDSLEFTSSENY
Newman EFTFVERKGENIYFNDSVEFIPSK--
USA300_FPR3757 EFTFVERKGENIYFNDSVEFIPSK--
******.: ***:*.**:** .*:
- ↑ Stephen R Garrett, Nicole Mietrach, Justin Deme, Alina Bitzer, Yaping Yang, Fatima R Ulhuq, Dorothee Kretschmer, Simon Heilbronner, Terry K Smith, Susan M Lea, Tracy Palmer
A type VII-secreted lipase toxin with reverse domain arrangement.
Nat Commun: 2023, 14(1);8438
[PubMed:38114483] [WorldCat.org] [DOI] (I e)Stephen R Garrett, Giuseppina Mariano, Jo Dicks, Tracy Palmer
Homologous recombination between tandem paralogues drives evolution of a subset of type VII secretion system immunity genes in firmicute bacteria.
Microb Genom: 2022, 8(8);
[PubMed:35960642] [WorldCat.org] [DOI] (I p)