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PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159JSNZLGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40
⊟Summary[edit | edit source]
- pan ID?: SAUPAN001395000
- symbol?: ssb2
- synonym:
- description?: single-strand binding protein
- single-strand binding protein
- single-stranded DNA-binding protein
- putative single-strand DNA-binding protein
- Single-stranded DNA-binding protein, phage associated
- ssDNA-binding protein
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 1679545..1680015
- synteny block?: BlockID0008740
- occurrence?: in 24% of 34 strains
ssb : prophage ssDNA-binding protein [1]
Single-stranded DNA-binding proteins (SSBs) protect 3'-ssDNA overhangs from degradation and are essential components of single-stranded DNA recombinases. There is powerful evolutionary pressure for structural diversity as SSBs are frequent targets for CRISPR-mediated anti-phage defenses and several SSB paralogues exist. Prophage SSBs are typically paired with a single-strand DNA exonuclease and a single-strand DNA recombinase.
⊟Orthologs[edit | edit source]
COL:
—
N315:
—
NCTC8325:
—
04-02981:
—
08BA02176:
—
11819-97:
—
6850:
—
71193:
—
ECT-R 2:
—
ED133:
SAOV_1956c
ED98:
—
HO 5096 0412:
—
JH1:
SaurJH1_0331
JH9:
SaurJH9_0322
JKD6008:
SAA6008_02038 (ssb2)
JKD6159:
—
JSNZ:
—
LGA251:
—
M013:
—
MRSA252:
—
MSHR1132:
—
MSSA476:
—
Mu3:
—
Mu50:
—
MW2:
—
RF122:
—
ST398:
—
T0131:
SAT0131_02119
TCH60:
—
TW20:
SATW20_03420
USA300_TCH1516:
USA300HOU_1989 (ssb2)
VC40:
—
⊟Genome Viewer[edit | edit source]
⊟Alignments[edit | edit source]
- alignment of orthologues:
- ↑ Simanti Datta, Nina Costantino, Xiaomei Zhou, Donald L Court
Identification and analysis of recombineering functions from Gram-negative and Gram-positive bacteria and their phages.
Proc Natl Acad Sci U S A: 2008, 105(5);1626-31
[PubMed:18230724] [WorldCat.org] [DOI] (I p)Maan M Neamah, Ignacio Mir-Sanchis, María López-Sanz, Sonia Acosta, Ignacio Baquedano, Andreas F Haag, Alberto Marina, Silvia Ayora, José R Penadés
Sak and Sak4 recombinases are required for bacteriophage replication in Staphylococcus aureus.
Nucleic Acids Res: 2017, 45(11);6507-6519
[PubMed:28475766] [WorldCat.org] [DOI] (I p)Janine Bowring, Maan M Neamah, Jorge Donderis, Ignacio Mir-Sanchis, Christian Alite, J Rafael Ciges-Tomas, Elisa Maiques, Iltyar Medmedov, Alberto Marina, José R Penadés
Pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer.
Elife: 2017, 6;
[PubMed:28826473] [WorldCat.org] [DOI] (I e)Kamil Steczkiewicz, Eric Prestel, Elena Bidnenko, Agnieszka K Szczepankowska
Expanding Diversity of Firmicutes Single-Strand Annealing Proteins: A Putative Role of Bacteriophage-Host Arms Race.
Front Microbiol: 2021, 12;644622
[PubMed:33959107] [WorldCat.org] [DOI] (P e)