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⊟Summary[edit | edit source]
- pan ID?: SAUPAN001094000
- symbol?: fadD
- synonym:
- description?: glutaryl-CoA dehydrogenase
- glutaryl-CoA dehydrogenase
- acyl-CoA dehydrogenase
- acyl-CoA dehydrogenase, putative
- acyl-CoA dehydrogenase FadD
- acyl-CoA dehydrogenase FadD-like protein
- acyl-CoA dehydrogenase family protein
- acyl-CoA dehydrogenase, middle domain-containing protein
- acyl-CoA dehydrogenase, N-terminal domain protein
- acyl-CoA dehydrogenase domain-containing protein
- NRAMP family Mn2+/Fe2+ transporter
- pseudogene
- putative acyl-CoA dehydrogenase
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 1370676..1371887
- synteny block?: BlockID0006160
- occurrence?: in 100% of 34 strains
fadE : acyl-CoA dehydrogenase [1]
• acyl-CoA dehydrogenase is the first committed step of fatty acid β-oxidation, generating a double bond desaturation at the 3-4 position of the thioesterified acyl acid.
*** Please note, most staphylococcal genome annotations currently have this enzyme misannotated as FadD. It is, in fact, FadE, the acyl-CoA dehydrogenase. The gene order in staphylococci is not alphabetical. ***
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0233
08BA02176:
C248_0217 (fadD)
11819-97:
MS7_0219
6850:
RSAU_000178 (fadD)
71193:
ST398NM01_0243
ECT-R 2:
ECTR2_193
ED133:
SAOV_0170
ED98:
SAAV_0198
HO 5096 0412:
SAEMRSA15_01910 (fadD)
JH1:
SaurJH1_0223
JH9:
SaurJH9_0217
JKD6008:
SAA6008_00202 (fadD)
JKD6159:
SAA6159_00207 (fadD)
JSNZ:
JSNZ_000170
LGA251:
SARLGA251_01970 (fadD)
M013:
M013TW_0212
MRSA252:
SAR0225 (fadD)
MSHR1132:
SAMSHR1132_01980
MSSA476:
SAS0209
Mu3:
SAHV_0232
Mu50:
SAV0233
MW2:
MW0209
RF122:
SAB0172c (fadD)
ST398:
SAPIG0243
T0131:
SAT0131_00220
TCH60:
HMPREF0772_10272 (fadD)
TW20:
SATW20_02340 (fadD)
USA300_TCH1516:
USA300HOU_0242
VC40:
SAVC_00905
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL ---------------MTFEKETVLKTLFPEDVLSIAKGLTDGEVEFLQQVDSLLESKYRE
N315 ---------------MTFEKETVLKTLFPEDVLSIAKGLTDGEVEFLQQVDSLLESNYRE
NCTC8325 ---------------MTFEKETVLKTLFPEDVLSIAKGLTDGEVEFLQQVDSLLESKYRE
Newman MHFTLVFILFLGGIYMTFEKETVLKTLFPEDVLSIAKGLTDGEVEFLQQVDSLLESKYRE
USA300_FPR3757 ---------------MTFEKETVLKTLFPEDVLSIAKGLTDGEVEFLQQVDSLLESKYRE
*****************************************:***
COL NINQHWIDATVPEDYFKDLGELNYFNNPLLYKDRPNAKMPSQLFQFFMSYLLARFDISLA
N315 NINQHWIDATVPEDYFKDLGELNYFNNPLLYKDRPNAKMPSQLFQFFMSYLLARFDISLA
NCTC8325 NINQHWIDATVPEDYFKDLGELNYFNNPLLYKDRPNAKMPSQLFQFFMSYLLARFDISLA
Newman NINQHWIDATVPEDYFKDLGELNYFNNPLLYKDRPNAKMPSQLFQFFMSYLLARFDISLA
USA300_FPR3757 NINQHWIDATVPEDYFKDLGELNYFNNPLLYKDRPNAKMPSQLFQFFMSYLLARFDISLA
************************************************************
COL TLLGVHQGLGHNTFYFGGSKEQIAKYVPKLQSHELRTCFALTEPEHGSDVAGGLETVAER
N315 TLLGVHQGLGHNTFYFGGSKEQIAKYVPKLLSHELRTCFALTEPEHGSDVAGGLETVAER
NCTC8325 TLLGVHQGLGHNTFYFGGSKEQIAKYVPKLQSHELRTCFALTEPEHGSDVAGGLETVAER
Newman TLLGVHQGLGHNTFYFGGSKEQIAKYVPKLQSHELRTCFALTEPEHGSDVAGGLETVAER
USA300_FPR3757 TLLGVHQGLGHNTFYFGGSKEQIAKYVPKLQSHELRTCFALTEPEHGSDVAGGLETVAER
****************************** *****************************
COL QGDTWVINGEKKWIGGAHVSDVIPVFAVNKETGKPHCFVVRPEQDGVDIEVIDNKIALRI
N315 QGDTWVINGEKKWIGGAHVSDVIPVFAVNKKTGKPHCFVVRPEQDGVDIEVIDNKIALRI
NCTC8325 QGDTWVINGEKKWIGGAHVSDVIPVFAVNKETGKPHCFVVRPEQDGVDIEVIDNKIALRI
Newman QGDTWVINGEKKWIGGAHVSDVIPVFAVNKETGKPHCFVVRPEQDGVDIEVIDNKIALRI
USA300_FPR3757 QGDTWVINGEKKWIGGAHVSDVIPVFAVNKETGKPHCFVVRPEQDGVDIEVIDNKIALRI
******************************:*****************************
COL VPNALIKLTNVKVDEADRLQNITSFKDIAKILYSTRAGVAYMATGGMAGALRATLDYVTE
N315 VPNALIKLTNVKVDEADRLQNITSFKDIAKILYSTRAGVAYMATGGMAGALRATLDYVTE
NCTC8325 VPNALIKLTNVKVDEADRLQNITSFKDIAKILYSTRAGVAYMATGGMAGALRATLDYVTE
Newman VPNALIKLTNVKVDEADRLQNITSFKDIAKILYSTRAGVAYMATGGMAGALRATLDYVTE
USA300_FPR3757 VPNALIKLTNVKVDEADRLQNITSFKDIAKILYSTRAGVAYMATGGMAGALRATLDYVTE
************************************************************
COL RKQFGKPISKYQLIQEKLAMMQGNLAQAMATCAQLANMQAHGEYDEVATSTAKMMNALRL
N315 RKQFGKPISKYQLIQEKLAMMQGNLAQAMATCAQLANMQAHGEYDEVATSTAKMMNALRL
NCTC8325 RKQFGKPISKYQLIQEKLAMMQGNLAQAMATCAQLANMQAHGEYDEVATSTAKMMNALRL
Newman RKQFGKPISKYQLIQEKLAMMQGNLAQAMATCAQLANMQAHGEYDEVATSTAKMMNALRL
USA300_FPR3757 RKQFGKPISKYQLIQEKLAMMQGNLAQAMATCAQLANMQAHGEYDEVATSTAKMMNALRL
************************************************************
COL RETVAMGRGITGGNGILADDYDIARFFSDAEAIYTYEGTHEINALVIGRALTGDSAFV
N315 RETVAMGRGITGGNGILADDYDIARFFSDAEAIYTYEGTHEINALVIGRALTGDSAFV
NCTC8325 RETVAMGRGITGGNGILADDYDIARFFSDAEAIYTYEGTHEINALVIGRALTGDSAFV
Newman RETVAMGRGITGGNGILADDYDIARFFSDAEAIYTYEGTHEINALVIGRALTGDSAFV
USA300_FPR3757 RETVAMGRGITGGNGILADDYDIARFFSDAEAIYTYEGTHEINALVIGRALTGDSAFV
**********************************************************
- ↑ Joshua R Fletcher, Alex R Villareal, Mitchell R Penningroth, Ryan C Hunter
Staphylococcus aureus Overcomes Anaerobe-Derived Short-Chain Fatty Acid Stress via FadX and the CodY Regulon.
J Bacteriol: 2022, 204(5);e0006422
[PubMed:35389253] [WorldCat.org] [DOI] (I p)Robert C Kuiack, Stephen W Tuffs, Karine Dufresne, Robert Flick, John K McCormick, Martin J McGavin
The fadXDEBA locus of Staphylococcus aureus is required for metabolism of exogenous palmitic acid and in vivo growth.
Mol Microbiol: 2023, 120(3);425-438
[PubMed:37501506] [WorldCat.org] [DOI] (I p)