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NCBI: 03-AUG-2016
⊟Summary[edit | edit source]
- organism: Staphylococcus aureus NCTC8325
- locus tag: SAOUHSC_02436
- pan locus tag?: SAUPAN005572000
- symbol: SAOUHSC_02436
- pan gene symbol?: sfnaD
- synonym:
- product: hypothetical protein
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SAOUHSC_02436
- symbol: SAOUHSC_02436
- product: hypothetical protein
- replicon: chromosome
- strand: +
- coordinates: 2262005..2263981
- length: 1977
- essential: no DEG other strains
⊟Accession numbers[edit | edit source]
- Gene ID: 3919001 NCBI
- RefSeq: YP_500905 NCBI
- BioCyc: G1I0R-2305 BioCyc
- MicrobesOnline: 1290876 MicrobesOnline
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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1921ATGAACTTGAACTTAATTTTTAAAGAACAGACATTAAAATTTAACAAAGAAGAACAAGAA
ACATATTTATTTTTACAACAACATAATAGCGATTGGGCTAATATTTTTAAAGAGATGATT
TTACAAGGAAGAGATAAAGTCACTCAGAGATTGGTCACATCAATGCATCGCGAAAACTTA
GTTAAAGCGCGCACTCAAAGTAAGAAAATATTGAGTCGTGATTTGATTATGTTAGATATC
TCAACGACTCATATACTAGAAATCCAGTTCCCACAAGCTAAGCAAACATTATATGCTCCT
ATCACTGGAGAACACGCCTTTGATCGAATTGATGTTGAAGGCCCTTTCTACATTAAAGAT
GACATTACAAATACGATTACACGAGTACACCATCCAAATGAAATTCTTGAGTGTATTTTA
ATTGAAGCACCAGATTTAAAAAATGCTGCTAGTGATCAATTTCAGCAAGATTTAATAAAC
AGTGCAACTAATATGACATTTGCAATTAGCTATCAAGCACTGTCAATGCAACATGATTCT
GCACCTTTATTTAATATTATCGAAAATAGCGAAGATAGTTACTTGCGTTCAGAGCAAGCC
GTTATTGAAGGTCATCCGCTACATCCTGGGGCTAAATTACGTAAAGGTTTAAATGCATTA
CAAACATTCCTATATTCTTCAGAATTCAATCAACCTATTAAGTTGAAAATAGTACTGATT
CACAGTAAATTAAGCCGTACTATGTCACTGTCTAAAGATTATGATACAACTGTTCATCAA
CTATTTCCGGACTTAATTAAACAATTAGAAAATGAATTTACGCCAAAGTTTAACTTTAAT
GATTATCACATTATGATTGTTCATCCATGGCAATTAGATGACGTATTACATTCTGATTAT
CAAGCAGAAGTAGATAAAGAATTAATCATTGAAGCAAAACATACGTTGGATTATTATGCT
GGTTTATCTTTCAGAACATTAGTTCCTAAATACCCAGCTATGTCGCCACACATCAAATTG
TCGACAAACGTTCATATTACAGGTGAGATTCGTACATTATCAGAACAAACGACGCACAAT
GGTCCACTAATGACACGTATTTTAAATGATATTTTGGAGAAAGATGTCATATTTAAGTCC
TATGCATCAACAATTATTGATGAAGTTGCTGGTATTCATTTTTATAATGAGCAAGACGAA
GCAGACTATCAAACTGAACGAAGTGAACAATTAGGTACATTATTTAGAAAAAATATATAC
CAAATGATTCCACAAGAAGTCACACCATTGATTCCTTCAAGCTTAGTTGCAACCTACCCA
TTTAACAATGAATCACCTATCGTGACATTGATTAAACGTTATCAATCAGCTGCATCATTG
TCTGATTTTGAATCATCGGCGAAATCGTGGGTTGAAACTTATAGTAAAGCATTGCTTGGT
CTCGTAATCCCACTAGTTACTAAATATGGCATTGCATTAGAGGCTCACTTGCAAAATGCT
ATTGCAACATTTCGGAAAGATGGTCTATTGGACACGATGTATATTAGAGACTTTGAAGGT
TTAAGAATTGATAAAGCACAACTAAATGAAATGGTATACAGTACATCTCATTTCCATGAA
AAATCAAGAATTCTTACTGATTCAAAAACGTCTGTGTTTAACAAAGCCTTTTATTCTACC
GTTCAAAACCATTTAGGCGAATTAATTCTTACAATCTCTAAAGCATCAAATGATTCAAAC
TTAGAAAGACATATGTGGTATATCGTTCGTGATGTACTAGATAACATTTTTGATCAACTT
GTACTTTCGACACACAAATCTAATCAAGTAAATGAGAATCGCATAAATGAAATTAAAGAT
ACCATGTTCGCGCCATTTATAGATTATAAGTGTGTTACAACAATGCGTCTTGAAGATGAG
GCACATCATTATACTTATATTAAAGTTAATAACCCTTTGTATCGAGAAAATAATTAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SAOUHSC_02436
- symbol: SAOUHSC_02436
- description: hypothetical protein
- length: 658
- theoretical pI: 6.09975
- theoretical MW: 76086.9
- GRAVY: -0.362614
⊟Function[edit | edit source]
- TIGRFAM:
- TheSEED :
- Siderophore synthetase superfamily, group B
- Uncharacterized siderophore biosynthesis protein near heme transporter HtsABC
- PFAM: PKinase (CL0016) IucA_IucC; IucA / IucC family (PF04183; HMM-score: 194.5)and 1 moreno clan defined FhuF; Ferric iron reductase FhuF-like transporter (PF06276; HMM-score: 107.3)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 7.5
- Cytoplasmic Membrane Score: 1.15
- Cellwall Score: 0.62
- Extracellular Score: 0.73
- Internal Helices: 0
- LocateP: Intracellular
- Prediction by SwissProt Classification: Cytoplasmic
- Pathway Prediction: No pathway
- Intracellular possibility: 1
- Signal peptide possibility: -1
- N-terminally Anchored Score: 1
- Predicted Cleavage Site: No CleavageSite
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.001636
- TAT(Tat/SPI): 0.000276
- LIPO(Sec/SPII): 0.000233
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MNLNLIFKEQTLKFNKEEQETYLFLQQHNSDWANIFKEMILQGRDKVTQRLVTSMHRENLVKARTQSKKILSRDLIMLDISTTHILEIQFPQAKQTLYAPITGEHAFDRIDVEGPFYIKDDITNTITRVHHPNEILECILIEAPDLKNAASDQFQQDLINSATNMTFAISYQALSMQHDSAPLFNIIENSEDSYLRSEQAVIEGHPLHPGAKLRKGLNALQTFLYSSEFNQPIKLKIVLIHSKLSRTMSLSKDYDTTVHQLFPDLIKQLENEFTPKFNFNDYHIMIVHPWQLDDVLHSDYQAEVDKELIIEAKHTLDYYAGLSFRTLVPKYPAMSPHIKLSTNVHITGEIRTLSEQTTHNGPLMTRILNDILEKDVIFKSYASTIIDEVAGIHFYNEQDEADYQTERSEQLGTLFRKNIYQMIPQEVTPLIPSSLVATYPFNNESPIVTLIKRYQSAASLSDFESSAKSWVETYSKALLGLVIPLVTKYGIALEAHLQNAIATFRKDGLLDTMYIRDFEGLRIDKAQLNEMVYSTSHFHEKSRILTDSKTSVFNKAFYSTVQNHLGELILTISKASNDSNLERHMWYIVRDVLDNIFDQLVLSTHKSNQVNENRINEIKDTMFAPFIDYKCVTTMRLEDEAHHYTYIKVNNPLYRENN
⊟Experimental data[edit | edit source]
- experimentally validated: PeptideAtlas [1] [2]
- protein localization: data available for COL
- quantitative data / protein copy number per cell:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
- predicted SigA promoter [3] : S947 > SAOUHSC_02436 > S948
⊟Regulation[edit | edit source]
- regulator: Fur* (repression) regulon
Fur* (TF) important in Iron homeostasis; RegPrecise
⊟Transcription pattern[edit | edit source]
- S.aureus Expression Data Browser: [3]
Multi-gene expression profiles
⊟Protein synthesis (provided by Aureolib)[edit | edit source]
⊟Protein stability[edit | edit source]
- half-life: no data available
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You are kindly invited to share additional interesting facts.
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ Maren Depke, Stephan Michalik, Alexander Rabe, Kristin Surmann, Lars Brinkmann, Nico Jehmlich, Jörg Bernhardt, Michael Hecker, Bernd Wollscheid, Zhi Sun, Robert L Moritz, Uwe Völker, Frank Schmidt
A peptide resource for the analysis of Staphylococcus aureus in host-pathogen interaction studies.
Proteomics: 2015, 15(21);3648-61
[PubMed:26224020] [WorldCat.org] [DOI] (I p) - ↑ Stephan Michalik, Maren Depke, Annette Murr, Manuela Gesell Salazar, Ulrike Kusebauch, Zhi Sun, Tanja C Meyer, Kristin Surmann, Henrike Pförtner, Petra Hildebrandt, Stefan Weiss, Laura Marcela Palma Medina, Melanie Gutjahr, Elke Hammer, Dörte Becher, Thomas Pribyl, Sven Hammerschmidt, Eric W Deutsch, Samuel L Bader, Michael Hecker, Robert L Moritz, Ulrike Mäder, Uwe Völker, Frank Schmidt
A global Staphylococcus aureus proteome resource applied to the in vivo characterization of host-pathogen interactions.
Sci Rep: 2017, 7(1);9718
[PubMed:28887440] [WorldCat.org] [DOI] (I e) - ↑ 3.0 3.1 3.2 Ulrike Mäder, Pierre Nicolas, Maren Depke, Jan Pané-Farré, Michel Debarbouille, Magdalena M van der Kooi-Pol, Cyprien Guérin, Sandra Dérozier, Aurelia Hiron, Hanne Jarmer, Aurélie Leduc, Stephan Michalik, Ewoud Reilman, Marc Schaffer, Frank Schmidt, Philippe Bessières, Philippe Noirot, Michael Hecker, Tarek Msadek, Uwe Völker, Jan Maarten van Dijl
Staphylococcus aureus Transcriptome Architecture: From Laboratory to Infection-Mimicking Conditions.
PLoS Genet: 2016, 12(4);e1005962
[PubMed:27035918] [WorldCat.org] [DOI] (I e)