PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159JSNZLGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 02-MAR-2017

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⊟Summary

• organism: Staphylococcus aureus COL
locus tag: SACOL_RS06135 [old locus tag: SACOL1198 ]
pan locus tag^?: SAUPAN003455000
symbol: SACOL_RS06135
pan gene symbol^?: ftsA
• synonym:
• product: cell division protein FtsA

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SACOL_RS06135 [old locus tag: SACOL1198 ]
• symbol: SACOL_RS06135
• product: cell division protein FtsA
• replicon: chromosome
• strand: +
• coordinates: 1203923..1205335
• length: 1413
• essential: unknown other strains

⊟Accession numbers

• Location: NC_002951 (1203923..1205335) NCBI
• BioCyc: SACOL_RS06135 BioCyc
• MicrobesOnline: see SACOL1198

⊟Phenotype

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⊟DNA sequence

• 1
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  ATGGAAGAACATTACTACGTAAGTATTGATATTGGATCATCAAGCGTAAAAACAATAGTA
  GGCGAGAAATTTCACAATGGTATAAATGTGATAGGTACAGGACAAACCTACACGAGCGGT
  ATAAAAAATGGTTTAATTGATGATTTTGATATTGCGCGACAAGCAATCAAAGACACAATT
  AAAAAGGCATCAATCGCTTCGGGTGTTGATATTAAAGAAGTTTTCCTGAAATTACCTATC
  ATTGGAACGGAAGTTTATGATGAATCAAATGAAATCGACTTTTATGAGGATACAGAAATC
  AACGGTTCACATATCGAAAAAGTATTAGAAGGTATTAGAGAAAAAAATGATGTGCAAGAA
  ACAGAAGTAATTAATGTGTTCCCGATTCGTTTTATAGTCGATAAAGAAAATGAGGTTTCA
  GACCCTAAAGAATTAATTGCCAGACATTCATTAAAGGTTGAAGCAGGCGTAATTGCTATT
  CAAAAATCGATTTTAATTAATATGATTAAATGCGTAGAAGCATGTGGTGTTGATGTATTA
  GATGTTTACTCTGATGCATATAACTATGGTTCAATCCTAACAGCTACTGAAAAAGAGTTA
  GGTGCATGTGTCATTGATATTGGTGAAGACGTTACGCAAGTTGCTTTTTATGAACGCGGT
  GAATTAGTAGATGCTGATTCTATCGAAATGGCAGGGCGTGATATTACAGACGATATTGCA
  CAAGGATTAAACACTTCTTATGAAACTGCTGAAAAAGTTAAACACCAATATGGTCATGCA
  TTCTATGATTCTGCTTCAGATCAAGATATCTTCACTGTTGAACAGGTTGATAGTGATGAA
  ACAGTACAGTATACTCAAAAAGATTTGAGTGACTTTATTGAAGCGCGTGTAGAAGAAATA
  TTCTTCGAAGTATTTGATGTTTTACAAGATTTAGGATTAACAAAAGTAAATGGTGGGTTT
  ATTGTAACTGGTGGATCTGCAAACTTACTTGGCGTAAAAGAATTATTATCAGATATGGTA
  AGTGAAAAAGTTAGAATTCACACGCCATCACAAATGGGAATTAGAAAACCTGAATTTTCT
  TCAGCAATTTCTACAATTTCTAGTAGTATCGCTTTTGATGAGTTATTAGATTATGTTACA
  ATTAATTATCATGATAATGAAGAAACTGAAGAAGATGTTATTGATGTGAAAGACAAAGAT
  AACGAATCTAAATTAGGCGGATTTGATTGGTTTAAACGTAAAACAAACAAAAAAGATACT
  CATGAAAATGAAGTAGAGTCAACAGATGAAGAAATTTATCAATCAGAAGATAATCATCAG
  GAACATAAACAGAATCATGAACATGTTCAAGACAAAGATAAAGATAAAGAAGAAAGTAAA
  TTCAAAAAACTAATGAAATCTCTATTTGAATGA
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⊟Protein

⊟General

• locus tag: SACOL_RS06135 [old locus tag: SACOL1198 ]
• symbol: SACOL_RS06135
• description: cell division protein FtsA
• length: 470
• theoretical pI: 4.21772
• theoretical MW: 52934.3
• GRAVY: -0.464468

⊟Function

• ⊞TIGRFAM:
  Cellular processes Cellular processes Cell division cell division protein FtsA (TIGR01174; HMM-score: 273.4)
  and 3 more
  Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan cell shape determining protein, MreB/Mrl family (TIGR00904; HMM-score: 39.7)
  type IV pilus assembly protein PilM (TIGR01175; HMM-score: 28.7)
  ethanolamine utilization protein EutJ family protein (TIGR02529; HMM-score: 20.1)
• TheSEED: see SACOL1198
• ⊞PFAM:
  Actin_ATPase (CL0108) FtsA; Cell division protein FtsA (PF14450; HMM-score: 118)
  and 6 more
  MreB_Mbl; MreB/Mbl protein (PF06723; HMM-score: 55.1)
  SHS2 (CL0319) SHS2_FTSA; SHS2 domain inserted in FTSA (PF02491; HMM-score: 40.2)
  Actin_ATPase (CL0108) PilM_2; Type IV pilus assembly protein PilM; (PF11104; HMM-score: 27.1)
  BcrAD_BadFG; BadF/BadG/BcrA/BcrD ATPase family (PF01869; HMM-score: 18.8)
  HAD (CL0137) HAD_SAK_1; HAD domain family 1 in Swiss Army Knife RNA repair proteins (PF10307; HMM-score: 18.1)
  no clan defined BDM; Putative biofilm-dependent modulation protein (PF10684; HMM-score: 15.1)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• ⊞DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.6278
  • Cytoplasmic Membrane Score: 0.3039
  • Cell wall & surface Score: 0.0009
  • Extracellular Score: 0.0674
• LocateP:
• ⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.043327
  • TAT(Tat/SPI): 0.000349
  • LIPO(Sec/SPII): 0.001222
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI: 446313176 NCBI
• RefSeq: WP_000391031 NCBI
• UniProt: see SACOL1198

⊟Protein sequence

• MEEHYYVSIDIGSSSVKTIVGEKFHNGINVIGTGQTYTSGIKNGLIDDFDIARQAIKDTIKKASIASGVDIKEVFLKLPIIGTEVYDESNEIDFYEDTEINGSHIEKVLEGIREKNDVQETEVINVFPIRFIVDKENEVSDPKELIARHSLKVEAGVIAIQKSILINMIKCVEACGVDVLDVYSDAYNYGSILTATEKELGACVIDIGEDVTQVAFYERGELVDADSIEMAGRDITDDIAQGLNTSYETAEKVKHQYGHAFYDSASDQDIFTVEQVDSDETVQYTQKDLSDFIEARVEEIFFEVFDVLQDLGLTKVNGGFIVTGGSANLLGVKELLSDMVSEKVRIHTPSQMGIRKPEFSSAISTISSSIAFDELLDYVTINYHDNEETEEDVIDVKDKDNESKLGGFDWFKRKTNKKDTHENEVESTDEEIYQSEDNHQEHKQNHEHVQDKDKDKEESKFKKLMKSLFE

⊟Experimental data

• experimentally validated: see SACOL1198
• protein localization: see SACOL1198
• quantitative data / protein copy number per cell: see SACOL1198
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: see SACOL1198

⊟Protein stability

• half-life: no data available

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications