PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 10-JUN-2013

⊟Summary

• organism: Staphylococcus aureus USA300_FPR3757
• locus tag: SAUSA300_1079 [new locus tag: SAUSA300_RS05850 ]
• pan locus tag^?: SAUPAN003455000
• symbol: ftsA
• pan gene symbol^?: ftsA
• synonym:
• product: cell division protein ftsA

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SAUSA300_1079 [new locus tag: SAUSA300_RS05850 ]
• symbol: ftsA
• product: cell division protein ftsA
• replicon: chromosome
• strand: +
• coordinates: 1180104..1181516
• length: 1413
• essential: unknown other strains

⊟Accession numbers

• Gene ID: 3913698 NCBI
• RefSeq: YP_493776 NCBI
• BioCyc: see SAUSA300_RS05850
• MicrobesOnline: 1292594 MicrobesOnline

⊟Phenotype

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⊟DNA sequence

• 1
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  ATGGAAGAACATTACTACGTAAGTATTGATATTGGATCATCAAGCGTAAAAACAATAGTA
  GGCGAGAAATTTCACAATGGTATAAATGTGATAGGTACAGGACAAACCTACACGAGCGGT
  ATAAAAAATGGTTTAATTGATGATTTTGATATTGCGCGACAAGCAATCAAAGACACAATT
  AAAAAGGCATCAATCGCTTCGGGTGTTGATATTAAAGAAGTTTTCCTGAAATTACCTATC
  ATTGGAACGGAAGTTTATGATGAATCAAATGAAATCGACTTTTATGAGGATACAGAAATC
  AACGGTTCACATATCGAAAAAGTATTAGAAGGTATTAGAGAAAAAAATGATGTGCAAGAA
  ACAGAAGTAATTAATGTGTTCCCGATTCGTTTTATAGTCGATAAAGAAAATGAGGTTTCA
  GACCCTAAAGAATTAATTGCCAGACATTCATTAAAGGTTGAAGCAGGCGTAATTGCTATT
  CAAAAATCGATTTTAATTAATATGATTAAATGCGTAGAAGCATGTGGTGTTGATGTATTA
  GATGTTTACTCTGATGCATATAACTATGGTTCAATCCTAACAGCTACTGAAAAAGAGTTA
  GGTGCATGTGTCATTGATATTGGTGAAGACGTTACGCAAGTTGCTTTTTATGAACGCGGT
  GAATTAGTAGATGCTGATTCTATCGAAATGGCAGGGCGTGATATTACAGACGATATTGCA
  CAAGGATTAAACACTTCTTATGAAACTGCTGAAAAAGTTAAACACCAATATGGTCATGCA
  TTCTATGATTCTGCTTCAGATCAAGATATCTTCACTGTTGAACAGGTTGATAGTGATGAA
  ACAGTACAGTATACTCAAAAAGATTTGAGTGACTTTATTGAAGCGCGTGTAGAAGAAATA
  TTCTTCGAAGTATTTGATGTTTTACAAGATTTAGGATTAACAAAAGTAAATGGTGGGTTT
  ATTGTAACTGGTGGATCTGCAAACTTACTTGGCGTAAAAGAATTATTATCAGATATGGTA
  AGTGAAAAAGTTAGAATTCACACGCCATCACAAATGGGAATTAGAAAACCTGAATTTTCT
  TCAGCAATTTCTACAATTTCTAGTAGTATCGCTTTTGATGAGTTATTAGATTATGTTACA
  ATTAATTATCATGATAATGAAGAAACTGAAGAAGATGTTATTGATGTGAAAGACAAAGAT
  AACGAATCTAAATTAGGCGGATTTGATTGGTTTAAACGTAAAACAAACAAAAAAGATACT
  CATGAAAATGAAGTAGAGTCAACAGATGAAGAAATTTATCAATCAGAAGATAATCATCAG
  GAACATAAACAGAATCATGAACATGTTCAAGACAAAGATAAAGATAAAGAAGAAAGTAAA
  TTCAAAAAACTAATGAAATCTCTATTTGAATGA
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⊟Protein

⊟General

• locus tag: SAUSA300_1079 [new locus tag: SAUSA300_RS05850 ]
• symbol: FtsA
• description: cell division protein ftsA
• length: 470
• theoretical pI: 4.21772
• theoretical MW: 52934.3
• GRAVY: -0.464468

⊟Function

• TIGRFAM:
  Cellular processes Cellular processes Cell division cell division protein FtsA (TIGR01174; HMM-score: 273.4)
  and 3 more
  Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan cell shape determining protein, MreB/Mrl family (TIGR00904; HMM-score: 39.7)
  type IV pilus assembly protein PilM (TIGR01175; HMM-score: 28.7)
  ethanolamine utilization protein EutJ family protein (TIGR02529; HMM-score: 20.1)
• TheSEED  :
  • Cell division protein FtsA
  Cell Division and Cell Cycle Cell Division and Cell Cycle - no subcategory Bacterial Cytoskeleton  Cell division protein FtsA
• PFAM:
  Actin_ATPase (CL0108) FtsA; Cell division protein FtsA (PF14450; HMM-score: 90.5)
  and 6 more
  MreB_Mbl; MreB/Mbl protein (PF06723; HMM-score: 55.2)
  SHS2 (CL0319) SHS2_FTSA; SHS2 domain inserted in FTSA (PF02491; HMM-score: 42.6)
  Actin_ATPase (CL0108) PilM_2; Type IV pilus assembly protein PilM; (PF11104; HMM-score: 28.3)
  no clan defined DUF2410; Hypothetical protein (DUF2410) (PF10307; HMM-score: 18.2)
  Actin_ATPase (CL0108) BcrAD_BadFG; BadF/BadG/BcrA/BcrD ATPase family (PF01869; HMM-score: 17.3)
  no clan defined BDM; Putative biofilm-dependent modulation protein (PF10684; HMM-score: 15.1)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• LocateP: Intracellular
  • Prediction by SwissProt Classification: Cytoplasmic
  • Pathway Prediction: No pathway
  • Intracellular possibility: 1
  • Signal peptide possibility: -1
  • N-terminally Anchored Score: 1
  • Predicted Cleavage Site: No CleavageSite
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.043327
  • TAT(Tat/SPI): 0.000349
  • LIPO(Sec/SPII): 0.001222
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI: 87161941 NCBI
• RefSeq: YP_493776 NCBI
• UniProt: A0A0H2XHQ1 UniProt

⊟Protein sequence

• MEEHYYVSIDIGSSSVKTIVGEKFHNGINVIGTGQTYTSGIKNGLIDDFDIARQAIKDTIKKASIASGVDIKEVFLKLPIIGTEVYDESNEIDFYEDTEINGSHIEKVLEGIREKNDVQETEVINVFPIRFIVDKENEVSDPKELIARHSLKVEAGVIAIQKSILINMIKCVEACGVDVLDVYSDAYNYGSILTATEKELGACVIDIGEDVTQVAFYERGELVDADSIEMAGRDITDDIAQGLNTSYETAEKVKHQYGHAFYDSASDQDIFTVEQVDSDETVQYTQKDLSDFIEARVEEIFFEVFDVLQDLGLTKVNGGFIVTGGSANLLGVKELLSDMVSEKVRIHTPSQMGIRKPEFSSAISTISSSIAFDELLDYVTINYHDNEETEEDVIDVKDKDNESKLGGFDWFKRKTNKKDTHENEVESTDEEIYQSEDNHQEHKQNHEHVQDKDKDKEESKFKKLMKSLFE

⊟Experimental data

• experimentally validated: data available for COL, NCTC8325
• protein localization: data available for COL
• quantitative data / protein copy number per cell: data available for COL
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: mraY > murD > divIB > ftsA > ftsZ

⊟Regulation

• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: data available for COL

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications