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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_002585
  • pan locus tag?: SAUPAN006301000
  • symbol: JSNZ_002585
  • pan gene symbol?: —
  • synonym:
  • product: aspartate aminotransferase family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_002585
  • symbol: JSNZ_002585
  • product: aspartate aminotransferase family protein
  • replicon: chromosome
  • strand: -
  • coordinates: 2590466..2591803
  • length: 1338
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    ATGAGTAAAGCACATCAATTAATTCAAGAGGATGAACATTATTTTGCGAAATCAGGACGT
    ATTAAATATTATCCGTTAGTGATTGATCATGGATATGGAGCAACATTGGTTGATATTGAG
    GGGAAGACATATATCGATTTGTTATCGAGTGCAAGTTCTCAAAACGTAGGTCATGCACCT
    AGAGAAGTAACAGAAGCGATAAAGGCACAAGTTGATAAATTTATTCATTATACACCAGCA
    TATATGTATCATGAACCGTTGGTACGTTTAGCTAAGAAGCTTTGTGAGCTTGCACCTGGA
    GATTTTGAAAAAAGAGTGACCTTCGGATTAACCGGATCAGACGCAAATGATGGCATCATT
    AAATTTGCCAGAGCATATACAGGGCGTCCTTATATCATTAGTTTCACTAACGCATATCAT
    GGTTCAACTTTTGGCTCATTGTCTATGTCAGCTATTAGTTTAAATATGCGCAAACATTAT
    GGTCCGTTATTGAATGGTTTTTATCATATTCCGTTTCCAGATAAATATCGTGGTATGTAC
    GAGCAGCCACAAGCTAATTCAGTAGAAGAATATTTAGCACCCTTAAAAGAAATGTTTGCG
    AAATATGTACCTGCTGACGAAGTAGCATGTATTGTTATTGAAACGATACAAGGCGATGGT
    GGACTTTTAGAACCAGTTCCAGGGTATTTTGAAGCGTTAGAAAAGATTTGTCGTGAACAT
    GGTATTTTAATCGCTGTCGATGATATTCAACAAGGTTTTGGGCGGACAGGTACATGGAGT
    TCAGTCTCGCATTTTAATTTTACGCCTGATTTAATCACTTTTGGAAAATCTTTAGCAGGT
    GGTATGCCTATGTCAGCAATTGTTGGACGCAAAGAGATTATGAATTGTTTAGAAGCACCA
    GCACATTTATTTACAACAGGTGCTAATCCAGTTAGTTGTGAAGCTGCATTAGCCACAATT
    CAAATGATTGAAGATCAGTCGCTTCTTCAGGCTAGTGCGGAAAAAGGGGAATATGTTAGG
    AAACGAATGGATCAATGGGTATCTAAATACAATAGTGTAGGCGATGTTAGAGGTAAAGGT
    CTGAGCATTGGTATTGATATTGTTTCCGACAAAAAACTCAAAACACGTGATGCCAGTGCG
    GCACTTAAAATTTGTAATTACTGCTTTGAGCATGGCGTAGTTATTATAGCTGTAGCAGGA
    AATGTGTTGCGATTCCAACCGCCATTGGTAATAACATATGAGCAATTAGACACGGCGTTA
    AACACTATAGAAGATGCACTGACTGCTTTGGAAGCAGGTAACTTAGATCAATATGACATA
    TCTGGACAAGGTTGGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1338

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_002585
  • symbol: JSNZ_002585
  • description: aspartate aminotransferase family protein
  • length: 445
  • theoretical pI: 5.90753
  • theoretical MW: 49081.7
  • GRAVY: -0.120899

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Central intermediary metabolism Other 4-aminobutyrate transaminase (TIGR00700; EC 2.6.1.19; HMM-score: 338.7)
    transaminase, acetylornithine/succinylornithine family (TIGR00707; HMM-score: 300.4)
    and 11 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Biotin adenosylmethionine-8-amino-7-oxononanoate transaminase (TIGR00508; EC 2.6.1.62; HMM-score: 254.2)
    ornithine--oxo-acid transaminase (TIGR01885; EC 2.6.1.13; HMM-score: 242.7)
    Metabolism Central intermediary metabolism Other 2,4-diaminobutyrate 4-transaminase (TIGR00709; EC 2.6.1.-; HMM-score: 225.9)
    Cellular processes Cellular processes Adaptations to atypical conditions diaminobutyrate--2-oxoglutarate aminotransferase (TIGR02407; EC 2.6.1.76; HMM-score: 216)
    Metabolism Energy metabolism Amino acids and amines succinylornithine transaminase family (TIGR03246; EC 2.6.1.81; HMM-score: 212.5)
    Metabolism Central intermediary metabolism Polyamine biosynthesis putrescine aminotransferase (TIGR03372; EC 2.6.1.82; HMM-score: 187.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin glutamate-1-semialdehyde-2,1-aminomutase (TIGR00713; EC 5.4.3.8; HMM-score: 167.8)
    L-lysine 6-transaminase (TIGR03251; EC 2.6.1.36; HMM-score: 132)
    Metabolism Central intermediary metabolism Other 4-aminobutyrate aminotransferase (TIGR00699; EC 2.6.1.19; HMM-score: 100.6)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Biotin 8-amino-7-oxononanoate synthase (TIGR00858; EC 2.3.1.47; HMM-score: 30.2)
    putative pyridoxal phosphate-dependent acyltransferase (TIGR01825; EC 2.3.1.-; HMM-score: 20)
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    PLP_aminotran (CL0061) Aminotran_3; Aminotransferase class-III (PF00202; HMM-score: 347.4)
    and 1 more
    Aminotran_1_2; Aminotransferase class I and II (PF00155; HMM-score: 15.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.67
    • Cytoplasmic Membrane Score: 0.01
    • Cellwall Score: 0.15
    • Extracellular Score: 0.17
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.982
    • Cytoplasmic Membrane Score: 0.0052
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0128
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.007652
    • TAT(Tat/SPI): 0.00033
    • LIPO(Sec/SPII): 0.000366
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSKAHQLIQEDEHYFAKSGRIKYYPLVIDHGYGATLVDIEGKTYIDLLSSASSQNVGHAPREVTEAIKAQVDKFIHYTPAYMYHEPLVRLAKKLCELAPGDFEKRVTFGLTGSDANDGIIKFARAYTGRPYIISFTNAYHGSTFGSLSMSAISLNMRKHYGPLLNGFYHIPFPDKYRGMYEQPQANSVEEYLAPLKEMFAKYVPADEVACIVIETIQGDGGLLEPVPGYFEALEKICREHGILIAVDDIQQGFGRTGTWSSVSHFNFTPDLITFGKSLAGGMPMSAIVGRKEIMNCLEAPAHLFTTGANPVSCEAALATIQMIEDQSLLQASAEKGEYVRKRMDQWVSKYNSVGDVRGKGLSIGIDIVSDKKLKTRDASAALKICNYCFEHGVVIIAVAGNVLRFQPPLVITYEQLDTALNTIEDALTALEAGNLDQYDISGQGW

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell: data available for COL
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: CodY (repression) regulon
    CodY(TF)important in Amino acid metabolism;  regulation predicted or transferred from N315 and NCTC 8325  [1]

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Hannes Wolfgramm, Larissa Milena Busch, Jöran Tebben, Henry Mehlan, Lisa Hagenau, Thomas Sura, Tilly Hoffmüller, Elisa Bludau, Manuela Gesell Salazar, Alexander Reder, Stephan Michalik, Leif Steil, Kristin Surmann, Ulrike Mäder, Silva Holtfreter, Uwe Völker
    Integrated genomic and proteomic analysis of the mouse-adapted Staphylococcus aureus strain JSNZ.
    Curr Res Microb Sci: 2025, 9;100489
    [PubMed:41146725] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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