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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_002278
  • pan locus tag?: SAUPAN005789000
  • symbol: JSNZ_002278
  • pan gene symbol?: —
  • synonym:
  • product: inositol monophosphatase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_002278
  • symbol: JSNZ_002278
  • product: inositol monophosphatase
  • replicon: chromosome
  • strand: -
  • coordinates: 2276143..2276940
  • length: 798
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGACAGATAAAACATTACAGCAAATAGATAAGTTAATATGTTCGTGGTTGAAACAAATA
    GACAATGTTATTCCGCAATTAATTATGGAAATGACTACAGAAACTAAGCGTCATCGATTT
    GATTTAGTTACAAATGTAGATAAACAGATTCAACAACAATTCCAACAATTTTTAGCAACA
    CATTTTCCGGAACACCAACTATTAGCGGAAGAAAAAAGTAATGAAATGATTACGAATGAA
    ATTAATCATTTATGGATTATGGATCCCATTGATGGAACTGCCAATTTAGTAAAACAGCAA
    GAAGATTATTGTATTATATTGGCGTATTTTTATGAAGGTAAACCAATGTTATCGTACGTA
    TATGATTATCCGCATAAAAAGCTTTATAAAGCAATACGAGGAGAAGGTGCTTTTTGTAAT
    GGAATTAAGATGGAAGAACCACCATCGTTAAAATTGGAAGACGCTATTATATCGTTTAAT
    GCACAAGTGATGAATCTAGATACGGTGCAAGATTTATTTGACGCCTCATTTAGTTATCGT
    TTAGTTGGTGCTTGCGGATTAGATTCTATGCGAGTGGCAAAAGGTCAATTTGGGGCACAT
    ATTAATACAAATCCTAAACCTTGGGACATTGCTGCACAGTTTTTATTTGCAGAACTATTG
    AATCTAAAAATGACGACTTTAGATGGTAAGGCAATTGATCATTTAAAGGGTGCACCTTTT
    ATTATAAGTAATAAAGCATGTCATGAAACGGTACTTAAAATTTTAAATGCAAATGGTGGT
    TATCAAAAATACAGATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    798

⊟Protein[edit | edit source]

Protein Data Bank: 5EYG
Protein Data Bank: 5EYH
Protein Data Bank: 5F24

⊟General[edit | edit source]

  • locus tag: JSNZ_002278
  • symbol: JSNZ_002278
  • description: inositol monophosphatase
  • length: 265
  • theoretical pI: 6.30614
  • theoretical MW: 30384.9
  • GRAVY: -0.264906

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Amino acid biosynthesis Histidine family histidinol-phosphatase (TIGR02067; EC 3.1.3.15; HMM-score: 89.8)
    and 3 more
    Metabolism Central intermediary metabolism Sulfur metabolism 3'(2'),5'-bisphosphate nucleotidase (TIGR01331; EC 3.1.3.7; HMM-score: 57.8)
    3'(2'),5'-bisphosphate nucleotidase (TIGR01330; EC 3.1.3.7; HMM-score: 24.4)
    TIGR03545 family protein (TIGR03545; HMM-score: 11.2)
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    Phospoesterase (CL0171) Inositol_P; Inositol monophosphatase family (PF00459; HMM-score: 134.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9383
    • Cytoplasmic Membrane Score: 0.0595
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.002
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001541
    • TAT(Tat/SPI): 0.000103
    • LIPO(Sec/SPII): 0.000337
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MTDKTLQQIDKLICSWLKQIDNVIPQLIMEMTTETKRHRFDLVTNVDKQIQQQFQQFLATHFPEHQLLAEEKSNEMITNEINHLWIMDPIDGTANLVKQQEDYCIILAYFYEGKPMLSYVYDYPHKKLYKAIRGEGAFCNGIKMEEPPSLKLEDAIISFNAQVMNLDTVQDLFDASFSYRLVGACGLDSMRVAKGQFGAHINTNPKPWDIAAQFLFAELLNLKMTTLDGKAIDHLKGAPFIISNKACHETVLKILNANGGYQKYR

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulators: CcpA regulon, SigB (activation) regulon
    CcpA(TF)important in Carbon catabolism;  regulation predicted or transferred from N315 and NCTC 8325  [1]
    SigB(sigma factor)controlling a large regulon involved in stress/starvation response and adaptation;  regulation predicted or transferred from N315 and NCTC 8325  [2] [3] [4]   other strains

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Hannes Wolfgramm, Larissa Milena Busch, Jöran Tebben, Henry Mehlan, Lisa Hagenau, Thomas Sura, Tilly Hoffmüller, Elisa Bludau, Manuela Gesell Salazar, Alexander Reder, Stephan Michalik, Leif Steil, Kristin Surmann, Ulrike Mäder, Silva Holtfreter, Uwe Völker
    Integrated genomic and proteomic analysis of the mouse-adapted Staphylococcus aureus strain JSNZ.
    Curr Res Microb Sci: 2025, 9;100489
    [PubMed:41146725] [WorldCat.org] [DOI] (I e)
  2. ↑ Markus Bischoff, Paul Dunman, Jan Kormanec, Daphne Macapagal, Ellen Murphy, William Mounts, Brigitte Berger-Bächi, Steven Projan
    Microarray-based analysis of the Staphylococcus aureus sigmaB regulon.
    J Bacteriol: 2004, 186(13);4085-99
    [PubMed:15205410] [WorldCat.org] [DOI] (P p)
  3. ↑ Jan Pané-Farré, Beate Jonas, Konrad Förstner, Susanne Engelmann, Michael Hecker
    The sigmaB regulon in Staphylococcus aureus and its regulation.
    Int J Med Microbiol: 2006, 296(4-5);237-58
    [PubMed:16644280] [WorldCat.org] [DOI] (P p)
  4. ↑ Bettina Schulthess, Dominik A Bloes, Patrice François, Myriam Girard, Jacques Schrenzel, Markus Bischoff, Brigitte Berger-Bächi
    The σB-dependent yabJ-spoVG operon is involved in the regulation of extracellular nuclease, lipase, and protease expression in Staphylococcus aureus.
    J Bacteriol: 2011, 193(18);4954-62
    [PubMed:21725011] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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