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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_001684
  • pan locus tag?: SAUPAN004347000
  • symbol: JSNZ_001684
  • pan gene symbol?: accA
  • synonym:
  • product: acetyl-CoA carboxylase carboxyltransferase subunit alpha

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_001684
  • symbol: JSNZ_001684
  • product: acetyl-CoA carboxylase carboxyltransferase subunit alpha
  • replicon: chromosome
  • strand: -
  • coordinates: 1723433..1724377
  • length: 945
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGTTAGATTTTGAAAAACCACTTTTTGAAATTCGAAATAAAATTGAATCTTTAAAAGAA
    TCTCAAGATAAAAATGATGTGGATTTACAAGAAGAAATTGACATGCTTGAAGCGTCATTG
    GAACGAGAAACTAAAAAAATATATACAAATCTAAAACCATGGGATCGTGTGCAAATTGCG
    CGTTTGCAAGAAAGACCTACGACCCTAGATTATATTCCATATATCTTTGATTCGTTTATG
    GAACTACATGGTGATCGTAATTTTAGAGATGATCCAGCAATGATTGGTGGTATTGGCTTT
    TTAAATGGTCGTGCTGTTACAGTTATTGGACAACAACGTGGAAAAGATACAAAAGATAAT
    ATTTATCGAAATTTTGGTATGGCGCATCCAGAAGGTTATCGAAAAGCATTACGTTTAATG
    AAACAAGCTGAAAAATTCAATCGTCCTATCTTTACATTTATAGATACAAAAGGTGCATAT
    CCTGGTAAAGCTGCTGAAGAACGTGGACAAAGTGAATCTATCGCAACAAATTTGATTGAG
    ATGGCTTCATTAAAAGTACCAGTTATTGCGATTGTCATTGGTGAAGGTGGCAGTGGAGGT
    GCTCTAGGTATTGGTATTGCCAATAAAGTATTGATGTTAGAGAATAGTACTTACTCTGTT
    ATATCTCCTGAAGGTGCAGCGGCATTATTATGGAAAGACAGTAATTTGGCTAAAATTGCA
    GCTGAAACAATGAAAATTACTGCCCATGATATTAAGCAATTAGGTATTATAGATGATGTC
    ATTTCTGAACCACTTGGCGGTGCACATAAAGATGTTGAACAGCAAGCTTTAGCTATTAAA
    TCAGCGTTTGTTGCACAGTTAGATTCACTTGAGTCATTATCACGTGATGAAATTGCTAAT
    GATCGCTTTGAAAAATTCAGAAATATCGGTTCTTATATAGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    945

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_001684
  • symbol: JSNZ_001684
  • description: acetyl-CoA carboxylase carboxyltransferase subunit alpha
  • length: 314
  • theoretical pI: 4.95687
  • theoretical MW: 35055.7
  • GRAVY: -0.34172

⊟Function[edit | edit source]

  • reaction:
    EC 6.4.1.2?  ExPASy
    Acetyl-CoA carboxylase ATP + acetyl-CoA + HCO3(-) = ADP + phosphate + malonyl-CoA
  • TIGRFAM:
    Metabolism Fatty acid and phospholipid metabolism Biosynthesis acetyl-CoA carboxylase, carboxyl transferase, alpha subunit (TIGR00513; EC 6.4.1.2; HMM-score: 486.8)
    and 4 more
    biotin-independent malonate decarboxylase, gamma subunit (TIGR03134; EC 4.1.1.88; HMM-score: 45.4)
    Metabolism Transport and binding proteins Cations and iron carrying compounds methylmalonyl-CoA decarboxylase alpha subunit (TIGR01117; EC 4.1.1.41; HMM-score: 29.6)
    Metabolism Energy metabolism Fermentation methylmalonyl-CoA decarboxylase alpha subunit (TIGR01117; EC 4.1.1.41; HMM-score: 29.6)
    Metabolism Energy metabolism ATP-proton motive force interconversion methylmalonyl-CoA decarboxylase alpha subunit (TIGR01117; EC 4.1.1.41; HMM-score: 29.6)
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    ClpP_crotonase (CL0127) ACCA; Acetyl co-enzyme A carboxylase carboxyltransferase-like (PF03255; HMM-score: 483.7)
    and 3 more
    Carboxyl_trans; Carboxyl transferase domain (PF01039; HMM-score: 57.7)
    ECH_1; Enoyl-CoA hydratase/isomerase (PF00378; HMM-score: 17.3)
    MdcE; Malonate decarboxylase gamma subunit (PF06833; HMM-score: 15)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.6933
    • Cytoplasmic Membrane Score: 0.1168
    • Cell wall & surface Score: 0.0003
    • Extracellular Score: 0.1896
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001877
    • TAT(Tat/SPI): 0.000609
    • LIPO(Sec/SPII): 0.000422
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MLDFEKPLFEIRNKIESLKESQDKNDVDLQEEIDMLEASLERETKKIYTNLKPWDRVQIARLQERPTTLDYIPYIFDSFMELHGDRNFRDDPAMIGGIGFLNGRAVTVIGQQRGKDTKDNIYRNFGMAHPEGYRKALRLMKQAEKFNRPIFTFIDTKGAYPGKAAEERGQSESIATNLIEMASLKVPVIAIVIGEGGSGGALGIGIANKVLMLENSTYSVISPEGAAALLWKDSNLAKIAAETMKITAHDIKQLGIIDDVISEPLGGAHKDVEQQALAIKSAFVAQLDSLESLSRDEIANDRFEKFRNIGSYIE

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell: data available for COL
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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