PangenomeCOLN315NCTC8325NewmanUSA300_FPR3757JSNZ04-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

FunGene: 08-OCT-2024

⊟Summary

• organism: Staphylococcus aureus JSNZ
• locus tag: JSNZ_000906
• pan locus tag^?: SAUPAN003043000
• symbol: JSNZ_000906
• pan gene symbol^?: —
• synonym:
• product: Na+/H+ antiporter family protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: JSNZ_000906
• symbol: JSNZ_000906
• product: Na+/H+ antiporter family protein
• replicon: chromosome
• strand: +
• coordinates: 903071..904387
• length: 1317
• essential: unknown other strains

⊟Accession numbers

• Gene ID:
• RefSeq:
• BioCyc:
• MicrobesOnline:

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  1141
  1201
  1261
  
  ATGATAAATGCAGTAGTAATAGCAGTAATTTTAATGATTGTGCTATGTTTATGTCGATTA
  AACGTAGTTATAAGCTTATTTATCAGTGCGCTAGTTGGTGGCGTAGTATCAGGTATGAGC
  ATTGAAAAAGTAATTAATGTATTCGGAAAAAATATAGTCGATGGTGCTGAGGTAGCATTA
  AGCTATGCCTTATTAGGTGGATTTGCAGCATTAATTTCATACAGTGGTATCACAGACTAT
  TTAGTAGGAAAAATTATAAATGCAATACACGCTGAAAATAGTCGATGGTCAAGAGTTAAA
  GTAAAAGTGACAATAATTATTGCATTATTAGCTATGAGTATCATGAGTCAAAACTTAATT
  CCTGTACATATTGCATTCATTCCAATTGTCATCCCACCATTGTTAAGTCTGTTTAATGAC
  TTAAAAATAGATAGACGTTTAATCGGTTTGATTATCGGTTTTGGTTTATGTTTCCCGTAT
  GTGTTATTACCATATGGATTCGGTCAAATTTTCCAGCAAATTATTCAAAGTGGCTTTGCA
  AAGGCAAATCACCCAATTGAGTTTAATATGATTTGGAAAGCAATGCTTATTCCTTCAATG
  GGGTATATTGTTGGCTTACTTATCGGTTTATATGTATATCGTAAACCACGTGAATATGAA
  ACACGTAAAATTTCAGATAGTGACAATGTTACAGAGTTAAAACCATATATCTTAATAGTA
  ACAATTGTAGCAATACTAGCTACATTTTTAGTACAAACATTTACAGATTCAATGATTTTT
  GGTGCACTGGCAGGGGTACTCGTATTCTTTATTTCACGTGCATATAATTGGTATGAATTA
  GATGCTAAGTTTGTTGAAGGTATTAAAATTATGGCTTATATTGGTGTAGTTATTTTAACA
  GCAAATGGATTTGCTGGTGTAATGAATGCTACTGGTGATATAGATGAATTAGTTAAAACT
  TTAACAAGTATTACTGGTGATAATAAATTATTTAGCATTATCATGATGTATGTGATAGGT
  TTAATTGTCACTTTAGGTATTGGATCATCATTTGCAACAATTCCTATTATCGCATCATTA
  TTCATTCCTTTTGGAGCGTCAATTGGACTAGATACAATGGCATTAATCGCATTGATTGGA
  ACAGCGAGTGCATTAGGTGACTCAGGTTCGCCTGCAAGTGATTCAACATTAGGACCAACT
  GCGGGATTAAATGTTGATGGCCAACATGATCATATACGTGATACATGTGTACCAAACTTC
  TTGTTTTATAATATTCCTTTAATGATTTTCGGTACTATTGCTGCTATGGTACTATAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  1020
  1080
  1140
  1200
  1260
  1317
  

⊟Protein

⊟General

• locus tag: JSNZ_000906
• symbol: JSNZ_000906
• description: Na+/H+ antiporter family protein
• length: 438
• theoretical pI: 6.6689
• theoretical MW: 47251.1
• GRAVY: 0.941096

⊟Function

• TIGRFAM:
  Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids TRAP transporter, DctM subunit (TIGR00786; HMM-score: 23.5)
  and 1 more
  Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids transporter, gluconate:H+ symporter (GntP) family (TIGR00791; HMM-score: 10.5)
• TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
• PFAM:
  IT (CL0182) Na_H_antiporter; Na+/H+ antiporter family (PF03553; HMM-score: 245.7)
  and 5 more
  Na_H_antiport_2; Na+-H+ antiporter family (PF13726; HMM-score: 112.3)
  DctM; Tripartite ATP-independent periplasmic transporter, DctM component (PF06808; HMM-score: 39.6)
  DcuC; C4-dicarboxylate anaerobic carrier (PF03606; HMM-score: 24.7)
  no clan defined AzlD; Branched-chain amino acid transport protein (AzlD) (PF05437; HMM-score: 13.9)
  IT (CL0182) GntP_permease; GntP family permease (PF02447; HMM-score: 11.9)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic Membrane
  • Cytoplasmic Score: 0
  • Cytoplasmic Membrane Score: 10
  • Cellwall Score: 0
  • Extracellular Score: 0
  • Internal Helices: 11
• DeepLocPro: Cytoplasmic Membrane
  • Cytoplasmic Score: 0
  • Cytoplasmic Membrane Score: 0.9997
  • Cell wall & surface Score: 0
  • Extracellular Score: 0.0003
• LocateP:
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.091114
  • TAT(Tat/SPI): 0.001045
  • LIPO(Sec/SPII): 0.075832
• predicted transmembrane helices (TMHMM): 12

⊟Accession numbers

• GI:
• RefSeq:
• UniProt:

⊟Protein sequence

• MINAVVIAVILMIVLCLCRLNVVISLFISALVGGVVSGMSIEKVINVFGKNIVDGAEVALSYALLGGFAALISYSGITDYLVGKIINAIHAENSRWSRVKVKVTIIIALLAMSIMSQNLIPVHIAFIPIVIPPLLSLFNDLKIDRRLIGLIIGFGLCFPYVLLPYGFGQIFQQIIQSGFAKANHPIEFNMIWKAMLIPSMGYIVGLLIGLYVYRKPREYETRKISDSDNVTELKPYILIVTIVAILATFLVQTFTDSMIFGALAGVLVFFISRAYNWYELDAKFVEGIKIMAYIGVVILTANGFAGVMNATGDIDELVKTLTSITGDNKLFSIIMMYVIGLIVTLGIGSSFATIPIIASLFIPFGASIGLDTMALIALIGTASALGDSGSPASDSTLGPTAGLNVDGQHDHIRDTCVPNFLFYNIPLMIFGTIAAMVL

⊟Experimental data

• experimentally validated: data available for NCTC8325
• protein localization: data available for COL
• quantitative data / protein copy number per cell:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator: HisR* (repression) regulon

  HisR*

  (TF)

  important in Histidine biosynthesis; transcription unit predicted or transferred from N315 and NCTC 8325 in Wolfgramm et al. (https://doi.org/10.1101/2025.09.03.674026)

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications