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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_000599
  • pan locus tag?: SAUPAN002508000
  • symbol: JSNZ_000599
  • pan gene symbol?: mntB
  • synonym:
  • product: metal ABC transporter permease

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_000599
  • symbol: JSNZ_000599
  • product: metal ABC transporter permease
  • replicon: chromosome
  • strand: -
  • coordinates: 634270..635106
  • length: 837
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGTTAGAGTTTGTCGAACATTTATTTACATATCAATTCTTGAATCGAGCATTGATAACT
    TCAATTATTGTAGGGATAGTTTGTGGTACAGTTGGTAGTTTAATTGTATTACGTGGTCTT
    TCATTAATGGGAGATGCAATGAGTCACGCAGTATTACCTGGTGTTGCCCTATCATTCTTA
    TTTGGTATTCCAATGTTTGTAGGCGCACTTATAACTGGTATGATCGCAAGTATTTTTATC
    GGTTATATCACATCTAGTAGTAAAACGAAACCTGACGCCGCTATTGGAATTAGTTTTACC
    GCTTTCTTAGCTTCGGGGATTATTATTATTAGCTTAATAAACACTACGACAGATTTGTAC
    CATATTCTGTTTGGTAATTTACTGGCAATCACAAATAGTGCATTTTTAACAACTATTGTG
    ATTGGTTCAATCGTCCTTATTCTAATCATTATTTTCTATCGTCCATTAATGATTTCTACA
    TTCGATCCAACGTTTAGTAGAATGAGTGGTCTAAATACGACGTTATTACATTACTTTGTG
    ATGTTGTTACTCTCATTAGTAACAGTAGCAAGTATTCAAACGGTAGGTATTATTCTTGTA
    GTTGCATTATTAATTACACCTGCATCTACAGCATTTTTAATTAGTAAAAAACTATACTCA
    ATGATGATTATAGCAAGTTTAATAAGTGTCATAAGTTCAATTGTCGGACTTTATTACAGC
    TATATTTACAACATTCCTAGTGGTGCGACAATCGTACTTTGTACGTTTGTAATTTATATC
    ATCACATTATTTTTCACAAAATTTACGAATAGAAAGAAACGAGGAAGTTTAACATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    837

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_000599
  • symbol: JSNZ_000599
  • description: metal ABC transporter permease
  • length: 278
  • theoretical pI: 9.77742
  • theoretical MW: 30104.2
  • GRAVY: 1.25108

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Transport and binding proteins Unknown substrate anchored repeat-type ABC transporter, permease subunit (TIGR03770; HMM-score: 182.1)
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    Membrane_trans (CL0142) ABC-3; ABC 3 transport family (PF00950; HMM-score: 260.9)
    and 4 more
    FecCD; FecCD transport family (PF01032; HMM-score: 28)
    no clan defined Cation_ATPase_C; Cation transporting ATPase, C-terminus (PF00689; HMM-score: 15.2)
    4HB_MCP (CL0457) 4HB_MCP_1; Four helix bundle sensory module for signal transduction (PF12729; HMM-score: 10.4)
    no clan defined Dsc3_C; DSC E3 ubiquitin ligase complex subunit 3, C-terminal domain (PF13373; HMM-score: 8.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 8
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 1
    • Cell wall & surface Score: 0
    • Extracellular Score: 0
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.007622
    • TAT(Tat/SPI): 0.001273
    • LIPO(Sec/SPII): 0.024432
  • predicted transmembrane helices (TMHMM): 8

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MLEFVEHLFTYQFLNRALITSIIVGIVCGTVGSLIVLRGLSLMGDAMSHAVLPGVALSFLFGIPMFVGALITGMIASIFIGYITSSSKTKPDAAIGISFTAFLASGIIIISLINTTTDLYHILFGNLLAITNSAFLTTIVIGSIVLILIIIFYRPLMISTFDPTFSRMSGLNTTLLHYFVMLLLSLVTVASIQTVGIILVVALLITPASTAFLISKKLYSMMIIASLISVISSIVGLYYSYIYNIPSGATIVLCTFVIYIITLFFTKFTNRKKRGSLT

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for NCTC8325
  • protein localization:
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: MntR* (repression) regulon
    MntR*(TF)important in Manganese homeostasis;  regulation predicted or transferred from N315 and NCTC 8325  [2]

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Blanca Taboada, Karel Estrada, Ricardo Ciria, Enrique Merino
    Operon-mapper: a web server for precise operon identification in bacterial and archaeal genomes.
    Bioinformatics: 2018, 34(23);4118-4120
    [PubMed:29931111] [WorldCat.org] [DOI] (I p)
  2. ↑ Hannes Wolfgramm, Larissa Milena Busch, Jöran Tebben, Henry Mehlan, Lisa Hagenau, Thomas Sura, Tilly Hoffmüller, Elisa Bludau, Manuela Gesell Salazar, Alexander Reder, Stephan Michalik, Leif Steil, Kristin Surmann, Ulrike Mäder, Silva Holtfreter, Uwe Völker
    Integrated genomic and proteomic analysis of the mouse-adapted Staphylococcus aureus strain JSNZ.
    Curr Res Microb Sci: 2025, 9;100489
    [PubMed:41146725] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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