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NCBI: 01-DEC-2025

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: EGJ38_002405 [new locus tag: EGJ38_RS12005 ]
  • pan locus tag?: SAUPAN005978000
  • symbol: gtxA
  • pan gene symbol?: —
  • synonym:
  • alternate name: JSNZ_002405
  • product: flippase GtxA

⊟Additional information (user-provided)[edit | edit source]

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: EGJ38_002405 [new locus tag: EGJ38_RS12005 ]
  • symbol: gtxA
  • product: flippase GtxA
  • replicon: chromosome
  • strand: -
  • coordinates: 2402729..2403115
  • length: 387
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq: MGT2424288 NCBI
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

⊟Additional information (user-provided)[edit | edit source]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    ATGAAACTAACACAAACGCATGCTGAAATTTTAAAATTTATCATTGTTGGCGGTATTAAT
    ACGTTGAATTATTATGTTGTCTATTTATTGCTGTTAAAATTATTTCACATTGAATATATG
    ATTAGTCATATTACCGGATTTATAGTTGCTTTTGTGATTTCTTATTATTTGAATTGTTAT
    TTTGTTTACAGAGTAAAACCTACTTGGAGAAAATTTATTAGTTTTCCAATTACGCAGCTT
    GTCAACGCAAGCTTACAAACAGTTTTATTATATGTTTTTGTATCCTGGCTAAATTTGCCA
    GCGGAAATTGCGCCATTTGCAGGTTTAGTGATTACGATACCCATCACATTTGTATTATCT
    AAATGGATTTTAAAAGATAGTAATTAA
    60
    120
    180
    240
    300
    360
    387


⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: EGJ38_002405 [new locus tag: EGJ38_RS12005 ]
  • symbol: GtxA
  • description: flippase GtxA
  • length: 128
  • theoretical pI: 9.70953
  • theoretical MW: 14870.8
  • GRAVY: 0.88125

⊟Function[edit | edit source]

  • TIGRFAM:
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    no clan defined GtrA_DPMS_TM; GtrA/DPMS, transmembrane domain (PF04138; HMM-score: 94.4)
    and 3 more
    MNHE; Na+/H+ ion antiporter subunit (PF01899; HMM-score: 10.8)
    DUF4229; Protein of unknown function (DUF4229) (PF14012; HMM-score: 9.6)
    Syndecan; Syndecan domain (PF01034; HMM-score: 8.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 4
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0.9999
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0001
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.000654
    • TAT(Tat/SPI): 0.000089
    • LIPO(Sec/SPII): 0.01395
  • predicted transmembrane helices (TMHMM): 4

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: MGT2424288 NCBI
  • UniProt:

⊟Additional information (user-provided)[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKLTQTHAEILKFIIVGGINTLNYYVVYLLLLKLFHIEYMISHITGFIVAFVISYYLNCYFVYRVKPTWRKFISFPITQLVNASLQTVLLYVFVSWLNLPAEIAPFAGLVITIPITFVLSKWILKDSN

⊟Experimental data[edit | edit source]

  • experimentally validated:
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: SigB (activation) regulon
    SigB(sigma factor)controlling a large regulon involved in stress/starvation response and adaptation;  [1] [2] [3]   other strains

⊟Additional information (user-provided)[edit | edit source]

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Additional information (user-provided)[edit | edit source]

⊟Other information (user-provided)[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Markus Bischoff, Paul Dunman, Jan Kormanec, Daphne Macapagal, Ellen Murphy, William Mounts, Brigitte Berger-Bächi, Steven Projan
    Microarray-based analysis of the Staphylococcus aureus sigmaB regulon.
    J Bacteriol: 2004, 186(13);4085-99
    [PubMed:15205410] [WorldCat.org] [DOI] (P p)
  2. ↑ Jan Pané-Farré, Beate Jonas, Konrad Förstner, Susanne Engelmann, Michael Hecker
    The sigmaB regulon in Staphylococcus aureus and its regulation.
    Int J Med Microbiol: 2006, 296(4-5);237-58
    [PubMed:16644280] [WorldCat.org] [DOI] (P p)
  3. ↑ Bettina Schulthess, Dominik A Bloes, Patrice François, Myriam Girard, Jacques Schrenzel, Markus Bischoff, Brigitte Berger-Bächi
    The σB-dependent yabJ-spoVG operon is involved in the regulation of extracellular nuclease, lipase, and protease expression in Staphylococcus aureus.
    J Bacteriol: 2011, 193(18);4954-62
    [PubMed:21725011] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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