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PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159JSNZLGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 03-AUG-2016

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⊟Summary[edit | edit source]

Contents

  • 1 Summary
  • 2 Genome View
  • 3 Gene
    • 3.1 General
    • 3.2 Accession numbers
    • 3.3 Phenotype
    • 3.4 DNA sequence
  • 4 Protein
    • 4.1 General
    • 4.2 Function
    • 4.3 Structure, modifications & cofactors
    • 4.4 Localization
    • 4.5 Accession numbers
    • 4.6 Protein sequence
    • 4.7 Experimental data
  • 5 Expression & Regulation
    • 5.1 Operon
    • 5.2 Regulation
    • 5.3 Transcription pattern
    • 5.4 Protein synthesis (provided by Aureolib)
    • 5.5 Protein stability
  • 6 Biological Material
    • 6.1 Mutants
    • 6.2 Expression vector
    • 6.3 lacZ fusion
    • 6.4 GFP fusion
    • 6.5 two-hybrid system
    • 6.6 FLAG-tag construct
    • 6.7 Antibody
  • 7 Other Information
  • 8 Literature
    • 8.1 References
    • 8.2 Relevant publications
  • organism: Staphylococcus aureus NCTC8325
  • locus tag: SAOUHSC_01964
  • pan locus tag?: SAUPAN004760000
  • symbol: SAOUHSC_01964
  • pan gene symbol?: traP
  • synonym:
  • product: hypothetical protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SAOUHSC_01964
  • symbol: SAOUHSC_01964
  • product: hypothetical protein
  • replicon: chromosome
  • strand: +
  • coordinates: 1870108..1870611
  • length: 504
  • essential: no DEG other strains

⊟Accession numbers[edit | edit source]

  • Gene ID: 3920909 NCBI
  • RefSeq: YP_500463 NCBI
  • BioCyc: G1I0R-1832 BioCyc
  • MicrobesOnline: 1290385 MicrobesOnline

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    ATGAAGAAACTATATACATCTTATGGCACTTATGGATTTTTACATCAGATAAAAATCAAT
    AACCCGACCCATCAACTATTCCAATTTTCAGCATCAGATACTTCAGTTATTTTTGAAGAA
    ACTGATGGTGAGACTGTTTTAAAATCACCTTCAATATATGAAGTTATTAAAGAAATTGGT
    GAATTCAGTGAACATCATTTCTATTGTGCAATCTTCATTCCATCAACAGAAGATCATGCA
    TATCAACTTGAAAAGAAACTGATTAGTGTAGACGATAATTTCAGAAACTTTGGTGGCTTT
    AAAAGCTATCGTTTGTTAAGACCTGCTAAAGGTACAACATACAAAATTTATTTCGGATTT
    GCTGATCGACATGCATACGAAGACTTTAAGCAATCTGATGCCTTTAATGACCATTTTTCA
    AAAGACGCATTAAGTCATTACTTTGGTTCAAGCGGACAACATTCAAGTTATTTTGAAAGA
    TATCTATACCCAATAAAAGAATAG
    60
    120
    180
    240
    300
    360
    420
    480
    504

⊟Protein[edit | edit source]

  • 4AE5
    PDB
Protein Data Bank: 4AE5

⊟General[edit | edit source]

  • locus tag: SAOUHSC_01964
  • symbol: SAOUHSC_01964
  • description: hypothetical protein
  • length: 167
  • theoretical pI: 6.60285
  • theoretical MW: 19547.6
  • GRAVY: -0.58024

⊟Function[edit | edit source]

  • TIGRFAM:
  • TheSEED  :
    • Heme-degrading monooxygenase, signal transduction protein TRAP
    Cofactors, Vitamins, Prosthetic Groups, Pigments Tetrapyrroles CPO analysis  Uncharacterized protein, homolog of B.subtilis yhgC
  • PFAM:
    Dim_A_B_barrel (CL0032) ABM; Antibiotic biosynthesis monooxygenase (PF03992; HMM-score: 22.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • ⊞DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.6648
    • Cytoplasmic Membrane Score: 0.2753
    • Cell wall & surface Score: 0.0014
    • Extracellular Score: 0.0585
  • ⊞LocateP: Intracellular
    • Prediction by SwissProt Classification: Cytoplasmic
    • Pathway Prediction: No pathway
    • Intracellular possibility: 1
    • Signal peptide possibility: -1
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.016961
    • TAT(Tat/SPI): 0.000155
    • LIPO(Sec/SPII): 0.001289
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI: 88195657 NCBI
  • RefSeq: YP_500463 NCBI
  • UniProt: Q2G2F3 UniProt
  • STRING: 93061.SAOUHSC_01964 STRING

⊟Protein sequence[edit | edit source]

  • MKKLYTSYGTYGFLHQIKINNPTHQLFQFSASDTSVIFEETDGETVLKSPSIYEVIKEIGEFSEHHFYCAIFIPSTEDHAYQLEKKLISVDDNFRNFGGFKSYRLLRPAKGTTYKIYFGFADRHAYEDFKQSDAFNDHFSKDALSHYFGSSGQHSSYFERYLYPIKE

⊟Experimental data[edit | edit source]

  • experimentally validated: PeptideAtlas [1] [2]
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell: data available for COL
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

  • MicrobesOnline: no polycistronic organisation predicted

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

  • S.aureus Expression Data Browser:  [3] 
    Expression Data Browser
    ⊟Multi-gene expression profiles



    Click on any data point to display a description of the corresponding condition!

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

  • Aureolib: data available for COL

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Maren Depke, Stephan Michalik, Alexander Rabe, Kristin Surmann, Lars Brinkmann, Nico Jehmlich, Jörg Bernhardt, Michael Hecker, Bernd Wollscheid, Zhi Sun, Robert L Moritz, Uwe Völker, Frank Schmidt
    A peptide resource for the analysis of Staphylococcus aureus in host-pathogen interaction studies.
    Proteomics: 2015, 15(21);3648-61
    [PubMed:26224020] [WorldCat.org] [DOI] (I p)
  2. ↑ Stephan Michalik, Maren Depke, Annette Murr, Manuela Gesell Salazar, Ulrike Kusebauch, Zhi Sun, Tanja C Meyer, Kristin Surmann, Henrike Pförtner, Petra Hildebrandt, Stefan Weiss, Laura Marcela Palma Medina, Melanie Gutjahr, Elke Hammer, Dörte Becher, Thomas Pribyl, Sven Hammerschmidt, Eric W Deutsch, Samuel L Bader, Michael Hecker, Robert L Moritz, Ulrike Mäder, Uwe Völker, Frank Schmidt
    A global Staphylococcus aureus proteome resource applied to the in vivo characterization of host-pathogen interactions.
    Sci Rep: 2017, 7(1);9718
    [PubMed:28887440] [WorldCat.org] [DOI] (I e)
  3. ↑ Ulrike Mäder, Pierre Nicolas, Maren Depke, Jan Pané-Farré, Michel Debarbouille, Magdalena M van der Kooi-Pol, Cyprien Guérin, Sandra Dérozier, Aurelia Hiron, Hanne Jarmer, Aurélie Leduc, Stephan Michalik, Ewoud Reilman, Marc Schaffer, Frank Schmidt, Philippe Bessières, Philippe Noirot, Michael Hecker, Tarek Msadek, Uwe Völker, Jan Maarten van Dijl
    Staphylococcus aureus Transcriptome Architecture: From Laboratory to Infection-Mimicking Conditions.
    PLoS Genet: 2016, 12(4);e1005962
    [PubMed:27035918] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

N Balaban, T Goldkorn, Y Gov, M Hirshberg, N Koyfman, H R Matthews, R T Nhan, B Singh, O Uziel
Regulation of Staphylococcus aureus pathogenesis via target of RNAIII-activating Protein (TRAP).
J Biol Chem: 2001, 276(4);2658-67
[PubMed:11160124] [WorldCat.org] [DOI] (P p)
Yael Gov, Ilya Borovok, Moshe Korem, Vineet K Singh, Radheshyam K Jayaswal, Brian J Wilkinson, Stephen M Rich, Naomi Balaban
Quorum sensing in Staphylococci is regulated via phosphorylation of three conserved histidine residues.
J Biol Chem: 2004, 279(15);14665-72
[PubMed:14726534] [WorldCat.org] [DOI] (P p)
Moshe Korem, Yael Gov, Madanahally D Kiran, Naomi Balaban
Transcriptional profiling of target of RNAIII-activating protein, a master regulator of staphylococcal virulence.
Infect Immun: 2005, 73(10);6220-8
[PubMed:16177293] [WorldCat.org] [DOI] (P p)

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  • This page was last edited on 11 March 2016, at 11:44.
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