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NCBI: 06-JUL-2013

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus Newman
  • locus tag: NWMN_1607 [new locus tag: NWMN_RS09010 ]
  • pan locus tag?: SAUPAN004365000
  • symbol: tpx
  • pan gene symbol?: tpx
  • synonym:
  • product: thiol peroxidase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: NWMN_1607 [new locus tag: NWMN_RS09010 ]
  • symbol: tpx
  • product: thiol peroxidase
  • replicon: chromosome
  • strand: -
  • coordinates: 1784698..1785192
  • length: 495
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    ATGACTGAAATAACATTCAAAGGTGGACCAATCCACTTAAAAGGTCAACAAATTAATGAA
    GGTGATTTTGCACCTGATTTTACAGTGTTAGATAATGACTTAAATCAAGTAACATTAGCA
    GATTATGCTGGTAAAAAGAAATTAATTAGTGTGGTACCATCAATTGATACAGGTGTTTGT
    GATCAGCAGACTCGCAAATTCAACTCTGATGCTTCTAAAGAAGAGGGGATTGTGCTTACA
    ATTTCAGCAGACTTACCATTCGCACAAAAAAGATGGTGCGCTTCAGCAGGTTTAGACAAT
    GTCATTACATTAAGTGACCACCGTGACTTATCATTTGGTGAAAACTATGGCGTTGTTATG
    GAAGAACTTCGCTTATTAGCTCGTGCAGTATTTGTATTAGATGCAGATAATAAAGTTGTT
    TATAAAGAAATCGTTAGTGAAGGTACTGATTTCCCAGATTTTGATGCTGCTTTAGCTGCA
    TACAAAAATATTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    495

⊟Protein[edit | edit source]

Protein Data Bank: 3P7X

⊟General[edit | edit source]

  • locus tag: NWMN_1607 [new locus tag: NWMN_RS09010 ]
  • symbol: Tpx
  • description: thiol peroxidase
  • length: 164
  • theoretical pI: 4.33649
  • theoretical MW: 18005.2
  • GRAVY: -0.134146

⊟Function[edit | edit source]

  • ⊞reaction:
    EC 1.11.1.15?  ExPASy
    Peroxiredoxin 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH
  • TIGRFAM:
    Cellular processes Cellular processes Detoxification peroxiredoxin (TIGR03137; EC 1.11.1.15; HMM-score: 25.2)
    Cellular processes Cellular processes Adaptations to atypical conditions peroxiredoxin (TIGR03137; EC 1.11.1.15; HMM-score: 25.2)
  • TheSEED  :
    • Thiol peroxidase, Tpx-type (EC 1.11.1.15)
    Sulfur Metabolism Sulfur Metabolism - no subcategory Thioredoxin-disulfide reductase  Thiol peroxidase, Tpx-type (EC 1.11.1.15)
  • ⊞PFAM:
    Thioredoxin (CL0172) Redoxin; Redoxin (PF08534; HMM-score: 104.7)
    and 1 more
    AhpC-TSA; AhpC/TSA family (PF00578; HMM-score: 67.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • ⊞DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.8472
    • Cytoplasmic Membrane Score: 0.0006
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.1521
  • ⊞LocateP: Intracellular
    • Prediction by SwissProt Classification: Cytoplasmic
    • Pathway Prediction: No pathway
    • Intracellular possibility: 1
    • Signal peptide possibility: -1
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003108
    • TAT(Tat/SPI): 0.000177
    • LIPO(Sec/SPII): 0.000493
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MTEITFKGGPIHLKGQQINEGDFAPDFTVLDNDLNQVTLADYAGKKKLISVVPSIDTGVCDQQTRKFNSDASKEEGIVLTISADLPFAQKRWCASAGLDNVITLSDHRDLSFGENYGVVMEELRLLARAVFVLDADNKVVYKEIVSEGTDFPDFDAALAAYKNI

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell: data available for COL
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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