PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159JSNZLGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 03-AUG-2016

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⊟Summary

• organism: Staphylococcus aureus NCTC8325
locus tag: SAOUHSC_00784
pan locus tag^?: SAUPAN002682000
symbol: SAOUHSC_00784
pan gene symbol^?: —
• synonym:
• product: hypothetical protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SAOUHSC_00784
• symbol: SAOUHSC_00784
• product: hypothetical protein
• replicon: chromosome
• strand: +
• coordinates: 765448..766887
• length: 1440
• essential: no DEG other strains

⊟Accession numbers

• Gene ID: 3919074 NCBI
• RefSeq: YP_499341 NCBI
• BioCyc: G1I0R-733 BioCyc
• MicrobesOnline: 1289251 MicrobesOnline

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
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  1321
  1381
  
  ATGGCGCAAAAGAATAATAATGTAATTCCAATGACTTTTGATGATGCATTTTATCGTAAA
  ATGGCTAAACAGAAGTTTAAACAAAGAGAATATAAACGAGCTGCTGAATACTTTGAAAAA
  GTGTTAGAATTGTCACCTGATGATCTGGAAATTCAAATTGATTATGCACAATGTCTAGTG
  CAACTTGGTATTGCTAAAAAAGCAGAACATTTATTTTATGACAATATTATTTATAATAGG
  CATCTAGAAGATAGCTTTTATGAATTGAGTCAGCTCAACATTGAAGTTAACGAACCAAAC
  AAGGCATTCTTGTTTGGTATTAATTATGTTATTGTTAGCGACGACCAAGATTATAGAGAT
  GAATTAGATCAAATGTTTGATGTGAAATATCAAAGTGAAGAACAAATTGAACTTGAAGCT
  CAATTGTTTGTAGTTCAAATACTATTCCAATATCTTTTTTCTCAAGGTCGATTAAAAGAT
  GCAAAGAATTATGTCTTACATCAACCACAAGAAGTTCAAGATCATCGTGTAGTACGTAAT
  TTATTGGCAATGTGTTATTTATATCTCGGTGAATATGATACGGCTAAAGCATTGTACGAA
  GCACTATTACAAGAGGATAGTACAGATATATATGCATTATGCCATTATACTTTGCTACTT
  TATAACACTAAGGAAAATGAACAATATCAAAAATATTTAAAAATATTAAACAAAGTTGTA
  CCTATGAATGACGATGAAAGTTTTAAATTAGGTATTGTATTAAGTTATTTAAAGCAGTAT
  CGTGCATCACAACAATTGTTGTACCCTTTATATAAAAAAGGGAAATTTTTATCAATTCAA
  ATGTACAATGCTTTAGCATATAATTATTATTATTTAGGTGAAGAAGACGAAAGTCATTAC
  TACTGGGATAAATTGAAGCAAATTTCTAAAGTGGAAATTGGACATGCGCCTTGGGTAATT
  GAAAATAGCAAAGAAGTTTTTGACCAACATATTTTGCCATTACTTCAAAGTGATGACAGT
  CATTATCGTTTATATGGTATTTTTTTATTGGATCAATTAAATGGTAAAGAAATTGTGATG
  ACGGAAAGTATTTGGCAGGTTTTGGAAAATCTAAATAATTATGAGAAATTGTATTTAACG
  TATTTAGTTCAAGGTTTAACGCTCAATAAATTAGACTTCATTCATCGCGGCTTATTAACG
  CTTTACCATAATGAATTATTTGTAAGTGAAAATGATGTAATGGTTGCATGGATTAATCAA
  GGTGAACTCATAATTGCTGAAAAAGTAGATTTAACTGATGTTGAGCCATATATCGGTGCG
  TTTATTTATTTGTATTTTAAAAATCAACCTCGAAACGTTACAAAGAAGCAAATTACAACA
  TGGTTAGGCATAACACAATATAAACTGAACAAAATGATTGAATTTCTCTTGAGCATATAG
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⊟Protein

⊟General

• locus tag: SAOUHSC_00784
• symbol: SAOUHSC_00784
• description: hypothetical protein
• length: 479
• theoretical pI: 4.82699
• theoretical MW: 57060.8
• GRAVY: -0.331106

⊟Function

• ⊞TIGRFAM:
  putative PEP-CTERM system TPR-repeat lipoprotein (TIGR02917; HMM-score: 36.1)
  and 3 more
  type IV pilus biogenesis/stability protein PilW (TIGR02521; HMM-score: 21.5)
  type III secretion low calcium response chaperone LcrH/SycD (TIGR02552; HMM-score: 18.4)
  Unknown function General heme biosynthesis-associated TPR protein (TIGR00540; HMM-score: 11.9)
• TheSEED  :
  • TPR domain protein
• ⊞PFAM:
  TPR (CL0020) TPR_19; Tetratricopeptide repeat (PF14559; HMM-score: 55)
  and 21 more
  TPR_14; Tetratricopeptide repeat (PF13428; HMM-score: 41.4)
  TPR_2; Tetratricopeptide repeat (PF07719; HMM-score: 35.7)
  ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3 (PF12895; HMM-score: 35.6)
  TPR_16; Tetratricopeptide repeat (PF13432; HMM-score: 35.2)
  TPR_CcmH_CycH; Cytochrome c-type biogenesis protein H TPR domain (PF23914; HMM-score: 33.7)
  TPR_12; Tetratricopeptide repeat (PF13424; HMM-score: 28.8)
  TPR_1; Tetratricopeptide repeat (PF00515; HMM-score: 26.5)
  ARM_TT21_5th; TT21 fifth ARM repeats domain (PF25064; HMM-score: 23.3)
  TPR_7; Tetratricopeptide repeat (PF13176; HMM-score: 23)
  TPR_10; Tetratricopeptide repeat (PF13374; HMM-score: 22.6)
  TPR_6; Tetratricopeptide repeat (PF13174; HMM-score: 21.8)
  Fis1_TPR_C; Fis1 C-terminal tetratricopeptide repeat (PF14853; HMM-score: 21.7)
  TPR_8; Tetratricopeptide repeat (PF13181; HMM-score: 21.4)
  TPR_17; Tetratricopeptide repeat (PF13431; HMM-score: 20.3)
  TPR_9; Tetratricopeptide repeat (PF13371; HMM-score: 15.9)
  TPR_Slam; Surface lipoprotein assembly modifier, N-terminal TPR repeats (PF24575; HMM-score: 15.6)
  TPR-S; Tetratricopeptide Repeats-Sensor (PF20308; HMM-score: 15.5)
  no clan defined ImpA_N; ImpA, N-terminal, type VI secretion system (PF06812; HMM-score: 12.5)
  TPR (CL0020) TPPII_C; Tripeptidyl peptidase II, C-terminal (PF12583; HMM-score: 12.2)
  no clan defined T6SS_VasJ; Type VI secretion, EvfE, EvfF, ImpA, BimE, VC_A0119, VasJ (PF16989; HMM-score: 10.9)
  TPR (CL0020) TPR_15; Tetratricopeptide repeat (PF13429; HMM-score: 9.2)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞PSORTb: Cytoplasmic Membrane
  • Cytoplasmic Score: 1.78
  • Cytoplasmic Membrane Score: 8.16
  • Cellwall Score: 0.06
  • Extracellular Score: 0.01
  • Internal Helices: 0
• ⊞DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.5972
  • Cytoplasmic Membrane Score: 0.3797
  • Cell wall & surface Score: 0.0081
  • Extracellular Score: 0.0149
• ⊞LocateP: Intracellular
  • Prediction by SwissProt Classification: Cytoplasmic
  • Pathway Prediction: No pathway
  • Intracellular possibility: 1
  • Signal peptide possibility: -1
  • N-terminally Anchored Score: 1
  • Predicted Cleavage Site: No CleavageSite
• ⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.002106
  • TAT(Tat/SPI): 0.00016
  • LIPO(Sec/SPII): 0.0002
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI: 88194545 NCBI
• RefSeq: YP_499341 NCBI
• UniProt: Q2G042 UniProt
• STRING: 93061.SAOUHSC_00784 STRING

⊟Protein sequence

• MAQKNNNVIPMTFDDAFYRKMAKQKFKQREYKRAAEYFEKVLELSPDDLEIQIDYAQCLVQLGIAKKAEHLFYDNIIYNRHLEDSFYELSQLNIEVNEPNKAFLFGINYVIVSDDQDYRDELDQMFDVKYQSEEQIELEAQLFVVQILFQYLFSQGRLKDAKNYVLHQPQEVQDHRVVRNLLAMCYLYLGEYDTAKALYEALLQEDSTDIYALCHYTLLLYNTKENEQYQKYLKILNKVVPMNDDESFKLGIVLSYLKQYRASQQLLYPLYKKGKFLSIQMYNALAYNYYYLGEEDESHYYWDKLKQISKVEIGHAPWVIENSKEVFDQHILPLLQSDDSHYRLYGIFLLDQLNGKEIVMTESIWQVLENLNNYEKLYLTYLVQGLTLNKLDFIHRGLLTLYHNELFVSENDVMVAWINQGELIIAEKVDLTDVEPYIGAFIYLYFKNQPRNVTKKQITTWLGITQYKLNKMIEFLLSI

⊟Experimental data

• experimentally validated: PeptideAtlas
• protein localization: data available for COL
• quantitative data / protein copy number per cell:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: SAOUHSC_00781 > SAOUHSC_00782 > SAOUHSC_00783 > SAOUHSC_00784 > SAOUHSC_00785
  predicted SigA promoter  : SAOUHSC_00781 > SAOUHSC_00782 > SAOUHSC_00783 > SAOUHSC_00784 > SAOUHSC_00785 > S309

⊟Regulation

• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser:   
  
  ⊟Multi-gene expression profiles

  Compare with:

  Conditions

  Select all flucRPMI-exp RPMI-exp-A2 vancRPMI-exp RPMI-exp-A1 TSB-exp-A TSB-exp-C ciproTSB-exp T/SmxTSB-exp clindTSB-exp lineTSB-exp eryTSB-exp TSB-exp-B3 flucTSB-exp TSB-exp-B2 vancTSB-exp TSB-exp-B1 RPMI/FCS-exp colist-exp intTHP1-2h intTHP1-6h intS9-6h intS9-2h TSB-t2-C TSB-t4-C flucTSB-t4 TSB-t2-B1 TSB-t4-B1 CDM-t2 CDM-t4 T/SmxTSB-t4 TSB-t4-B3 lineTSB-t4 TSB-t4-B2 vancTSB-t4 eryTSB-t4 clindTSB-t4 ciproTSB-t4 pMEM-t2-C1 pMEM-t4-C1 CO2-6h CO2-2h anaer-2h nonad50-1h CO2-1h nonad25-1h pMEM-exp-C2 pMEM-exp-C1 CDM-exp plasma-t4 vancRPMI-t4 flucRPMI-t4 RPMI-t4-A2 RPMI-t2-A1 plasma-exp

  
  
  Click on any data point to display a description of the corresponding condition!

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications