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NCBI: 10-JUN-2013

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL0828 [new locus tag: SACOL_RS04255 ]
  • pan locus tag?: SAUPAN002682000
  • symbol: SACOL0828
  • pan gene symbol?: —
  • synonym:
  • product: TPR domain-containing protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SACOL0828 [new locus tag: SACOL_RS04255 ]
  • symbol: SACOL0828
  • product: TPR domain-containing protein
  • replicon: chromosome
  • strand: +
  • coordinates: 853270..854709
  • length: 1440
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    ATGGCGCAAAAGAATAATAATGTAATTCCAATGACTTTTGATGATGCATTTTATCGTAAA
    ATGGCTAAACAGAAGTTTAAACAAAGAGAATATAAACGAGCTGCTGAATACTTTGAAAAA
    GTGTTAGAATTGTCACCTGATGATATGGAAATTCAAATTGATTATGCACAATGTCTAGTG
    CAACTTGGTATTGCTAAAAAAGCAGAACATTTATTTTATGACAATATTATTTATAATAGG
    CATCTAGAAGATAGCTTTTATGAATTGAGTCAGCTCAACATTGAAGTTAACGAACCAAAC
    AAGGCATTCTTGTTTGGTATTAATTATGTTATTGTTAGCGACGACCAAGATTATAGAGAT
    GAATTAGATCAAATGTTTGATGTGAAATATCAAAGTGAAGAACAAATTGAACTTGAAGCT
    CAATTGTTTGTAGTTCAAATACTATTCCAATATCTTTTTTCTCAAGGTCGATTAAAAGAT
    GCAAAGAATTATGTCTTACATCAACCACAAGAAGTTCAAGATCATCGTGTAGTACGTAAT
    TTATTGGCAATGTGTTATTTATATCTCGGTGAATATGATAGGGCTAAAGCATTGTACGAA
    GCACTATTACAAGAGGATAGTACAGATATATATGCATTATGCCATTATACTTTGCTACTT
    TATAACACTAAGGAAAATGAACAATATCAAAAATATTTAAAAATATTAAACAAAGTTGTA
    CCTATGAATGACGATGAAAGTTTTAAATTAGGTATTGTATTAAGTTATTTAAAGCAGTAT
    CGTGCATCACAACAATTGTTGTACCCTTTATATAAAAAAGGGAAATTTTTATCAATTCAA
    ATGTACAATGCTTTAGCATATAATTATTATTATTTAGGTGAAGAAGACGAAAGTCATTAC
    TACTGGGATAAATTGAAGCAAATTTCTAAAGTGGAAATTGGACATGCGCCTTGGGTAATT
    GAAAATAGCAAAGAAGTTTTTGACCAACATATTTTGCCATTACTTCAAAGTGATGACAGT
    CATTATCGTTTATATGGTATTTTTTTATTGGATCAATTAAATGGTAAAGAAATTGTGATG
    ACGGAAAGTATTTGGCAGGTTTTGGAAAATCTAAATAATTATGAGAAATTGTATTTAACG
    TATTTAGTTCAAGGTTTAACGCTCAATAAATTAGACTTCATTCATCGCGGCTTATTAACG
    CTTTACCATAATGAATTATTTGTAAGTGAAAATGATGTAATGGTTGCATGGATTAATCAA
    GGTGAACTCATAATTGCTGAAAAAGTAGATTTAACTGATGTTGAGCCATATATCGGTGCG
    TTTATTTATTTGTATTTTAAAAATCAACCTCGAAACGTTACAAAGAAGCAAATTACAACA
    TGGTTAGGCATAACACAATATAAACTGAACAAAATGATTGAATTTCTCTTGAGCATATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SACOL0828 [new locus tag: SACOL_RS04255 ]
  • symbol: SACOL0828
  • description: TPR domain-containing protein
  • length: 479
  • theoretical pI: 4.88248
  • theoretical MW: 57134
  • GRAVY: -0.343006

⊟Function[edit | edit source]

  • TIGRFAM:
    putative PEP-CTERM system TPR-repeat lipoprotein (TIGR02917; HMM-score: 36.8)
    and 3 more
    type IV pilus biogenesis/stability protein PilW (TIGR02521; HMM-score: 21.3)
    type III secretion low calcium response chaperone LcrH/SycD (TIGR02552; HMM-score: 18.9)
    Unknown function General heme biosynthesis-associated TPR protein (TIGR00540; HMM-score: 12)
  • TheSEED  :
    • TPR domain protein
  • PFAM:
    TPR (CL0020) TPR_19; Tetratricopeptide repeat (PF14559; HMM-score: 53)
    and 16 more
    TPR_2; Tetratricopeptide repeat (PF07719; HMM-score: 38.3)
    TPR_14; Tetratricopeptide repeat (PF13428; HMM-score: 37.7)
    TPR_16; Tetratricopeptide repeat (PF13432; HMM-score: 34.9)
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3 (PF12895; HMM-score: 34)
    TPR_7; Tetratricopeptide repeat (PF13176; HMM-score: 28.3)
    TPR_12; Tetratricopeptide repeat (PF13424; HMM-score: 28.1)
    TPR_1; Tetratricopeptide repeat (PF00515; HMM-score: 26.7)
    Fis1_TPR_C; Fis1 C-terminal tetratricopeptide repeat (PF14853; HMM-score: 23.9)
    TPR_6; Tetratricopeptide repeat (PF13174; HMM-score: 21.8)
    TPR_8; Tetratricopeptide repeat (PF13181; HMM-score: 20.4)
    TPR_10; Tetratricopeptide repeat (PF13374; HMM-score: 20.1)
    TPR_9; Tetratricopeptide repeat (PF13371; HMM-score: 17.4)
    TPR_17; Tetratricopeptide repeat (PF13431; HMM-score: 15.7)
    TPR_15; Tetratricopeptide repeat (PF13429; HMM-score: 13.9)
    no clan defined ImpA_N; ImpA, N-terminal, type VI secretion system (PF06812; HMM-score: 12.7)
    TPR (CL0020) Alkyl_sulf_dimr; Alkyl sulfatase dimerisation (PF14863; HMM-score: 12.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • LocateP: Intracellular
    • Prediction by SwissProt Classification: Cytoplasmic
    • Pathway Prediction: No pathway
    • Intracellular possibility: 1
    • Signal peptide possibility: -1
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002221
    • TAT(Tat/SPI): 0.000164
    • LIPO(Sec/SPII): 0.000212
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MAQKNNNVIPMTFDDAFYRKMAKQKFKQREYKRAAEYFEKVLELSPDDMEIQIDYAQCLVQLGIAKKAEHLFYDNIIYNRHLEDSFYELSQLNIEVNEPNKAFLFGINYVIVSDDQDYRDELDQMFDVKYQSEEQIELEAQLFVVQILFQYLFSQGRLKDAKNYVLHQPQEVQDHRVVRNLLAMCYLYLGEYDRAKALYEALLQEDSTDIYALCHYTLLLYNTKENEQYQKYLKILNKVVPMNDDESFKLGIVLSYLKQYRASQQLLYPLYKKGKFLSIQMYNALAYNYYYLGEEDESHYYWDKLKQISKVEIGHAPWVIENSKEVFDQHILPLLQSDDSHYRLYGIFLLDQLNGKEIVMTESIWQVLENLNNYEKLYLTYLVQGLTLNKLDFIHRGLLTLYHNELFVSENDVMVAWINQGELIIAEKVDLTDVEPYIGAFIYLYFKNQPRNVTKKQITTWLGITQYKLNKMIEFLLSI

⊟Experimental data[edit | edit source]

  • experimentally validated: PeptideAtlas
  • protein localization: Cytoplasmic [1] [2]
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Dörte Becher, Kristina Hempel, Susanne Sievers, Daniela Zühlke, Jan Pané-Farré, Andreas Otto, Stephan Fuchs, Dirk Albrecht, Jörg Bernhardt, Susanne Engelmann, Uwe Völker, Jan Maarten van Dijl, Michael Hecker
    A proteomic view of an important human pathogen--towards the quantification of the entire Staphylococcus aureus proteome.
    PLoS One: 2009, 4(12);e8176
    [PubMed:19997597] [WorldCat.org] [DOI] (I e)
  2. ↑ Andreas Otto, Jan Maarten van Dijl, Michael Hecker, Dörte Becher
    The Staphylococcus aureus proteome.
    Int J Med Microbiol: 2014, 304(2);110-20
    [PubMed:24439828] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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