PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159JSNZLGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 02-MAR-2017

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⊟Summary

• organism: Staphylococcus aureus COL
locus tag: SACOL_RS07400 [old locus tag: SACOL1451 ]
pan locus tag^?: SAUPAN003835000
symbol: SACOL_RS07400
pan gene symbol^?: arlR
• synonym:
• product: DNA-binding response regulator

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SACOL_RS07400 [old locus tag: SACOL1451 ]
• symbol: SACOL_RS07400
• product: DNA-binding response regulator
• replicon: chromosome
• strand: -
• coordinates: 1465407..1466066
• length: 660
• essential: unknown other strains

⊟Accession numbers

• Location: NC_002951 (1465407..1466066) NCBI
• BioCyc: SACOL_RS07400 BioCyc
• MicrobesOnline: see SACOL1451

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

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  ATGACGCAAATTTTAATAGTAGAAGATGAACAAAACTTAGCAAGATTTCTTGAATTGGAA
  CTCACACATGAAAATTACAATGTGGACACAGAGTATGATGGACAAGACGGTTTAGATAAA
  GCGCTTAGCCATTACTATGATTTAATCATATTAGATTTAATGTTGCCGTCAATTAATGGC
  TTAGAAATTTGTCGCAAAATTAGACAACAACAATCTACACCTATCATTATAATTACAGCG
  AAAAGTGATACGTATGACAAAGTTGCTGGGCTTGATTACGGTGCAGACGATTATATAGTT
  AAGCCGTTTGATATTGAAGAACTTTTAGCAAGAATTCGTGCAATTTTACGTCGTCAGCCA
  CAAAAGGATATTATCGATGTCAACGGTATTACAATTGATAAGAACGCTTTTAAAGTGACG
  GTAAATGGCGCAGAAATTGAATTAACAAAAACAGAGTATGATTTACTATATCTTCTAGCT
  GAAAATAAAAACCATGTTATGCAACGGGAACAAATTTTAAATCATGTATGGGGTTATAAT
  AGTGAAGTAGAAACAAATGTCGTAGATGTTTATATAAGATATTTACGAAACAAGTTAAAA
  CCATACGATCGTGACAAAATGATTGAAACAGTTCGTGGCGTTGGGTATGTGATACGATGA
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⊟Protein

⊟General

• locus tag: SACOL_RS07400 [old locus tag: SACOL1451 ]
• symbol: SACOL_RS07400
• description: DNA-binding response regulator
• length: 219
• theoretical pI: 4.63339
• theoretical MW: 25497.9
• GRAVY: -0.331507

⊟Function

• ⊞TIGRFAM:
  Signal transduction Regulatory functions DNA interactions phosphate regulon transcriptional regulatory protein PhoB (TIGR02154; HMM-score: 226.4)
  Signal transduction Signal transduction Two-component systems phosphate regulon transcriptional regulatory protein PhoB (TIGR02154; HMM-score: 226.4)
  Signal transduction Regulatory functions DNA interactions heavy metal response regulator (TIGR01387; HMM-score: 221)
  and 8 more
  proteobacterial dedicated sortase system response regulator (TIGR03787; HMM-score: 113.5)
  Metabolism Central intermediary metabolism Nitrogen metabolism nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 62.2)
  Signal transduction Regulatory functions DNA interactions nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 62.2)
  Signal transduction Signal transduction Two-component systems nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 62.2)
  Cellular processes Cellular processes Sporulation and germination sporulation transcription factor Spo0A (TIGR02875; HMM-score: 57.7)
  Signal transduction Signal transduction Two-component systems TMAO reductase sytem sensor TorS (TIGR02956; EC 2.7.13.3; HMM-score: 32.6)
  Signal transduction Regulatory functions DNA interactions PEP-CTERM-box response regulator transcription factor (TIGR02915; HMM-score: 31)
  Genetic information processing Mobile and extrachromosomal element functions Prophage functions putative phage terminase, small subunit, P27 family (TIGR01558; HMM-score: 13)
• TheSEED: see SACOL1451
• ⊞PFAM:
  CheY (CL0304) Response_reg; Response regulator receiver domain (PF00072; HMM-score: 108.9)
  HTH (CL0123) Trans_reg_C; Transcriptional regulatory protein, C terminal (PF00486; HMM-score: 100.4)
  and 4 more
  E-set (CL0159) Glucodextran_B; Glucodextranase, domain B (PF09136; HMM-score: 17.4)
  CheY (CL0304) iREC; Inactive Receiver domain (PF22563; HMM-score: 17)
  GlnR_1st; Transcription regulator GlnR, N-terminal domain (PF21695; HMM-score: 13.3)
  PDE8A_N; PDE8A-like, N-terminal domain (PF23198; HMM-score: 13.2)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞PSORTb: Cytoplasmic
  • Cytoplasmic Score: 9.97
  • Cytoplasmic Membrane Score: 0
  • Cellwall Score: 0.01
  • Extracellular Score: 0.02
  • Internal Helices: 0
• ⊞DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.991
  • Cytoplasmic Membrane Score: 0.0015
  • Cell wall & surface Score: 0.0002
  • Extracellular Score: 0.0073
• LocateP:
• ⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.001435
  • TAT(Tat/SPI): 0.000091
  • LIPO(Sec/SPII): 0.000226
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI: 446114282 NCBI
• RefSeq: WP_000192137 NCBI
• UniProt: see SACOL1451

⊟Protein sequence

• MTQILIVEDEQNLARFLELELTHENYNVDTEYDGQDGLDKALSHYYDLIILDLMLPSINGLEICRKIRQQQSTPIIIITAKSDTYDKVAGLDYGADDYIVKPFDIEELLARIRAILRRQPQKDIIDVNGITIDKNAFKVTVNGAEIELTKTEYDLLYLLAENKNHVMQREQILNHVWGYNSEVETNVVDVYIRYLRNKLKPYDRDKMIETVRGVGYVIR

⊟Experimental data

• experimentally validated: see SACOL1451
• protein localization: see SACOL1451
• quantitative data / protein copy number per cell: see SACOL1451
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• data available for N315, NCTC8325, Newman

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications