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NCBI: 10-JUN-2013

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL1785 [new locus tag: SACOL_RS09140 ]
  • pan locus tag?: SAUPAN004399000
  • symbol: acuC
  • pan gene symbol?: acuC
  • synonym:
  • product: acetoin utilization protein AcuC

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SACOL1785 [new locus tag: SACOL_RS09140 ]
  • symbol: acuC
  • product: acetoin utilization protein AcuC
  • replicon: chromosome
  • strand: +
  • coordinates: 1829038..1830207
  • length: 1170
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATGCAACAACATTCATCAAAAACTGCATATGTTTATTCAGATAAGTTATTACAATATCGA
    TTTCATGACCAACATCCCTTCAATCAAATGCGTTTAAAATTAACAACAGAGCTACTTTTG
    AATGCAAATTTATTGTCTCCAGAACAAATAGTACAACCTAGAATTGCAACAGATGACGAA
    TTAATGTTAATTCATAAATATGATTACGTCGAAGCTATTAAGCATGCTTCACATGGCATT
    ATCAGTGAAGATGAGGCTAAGAAATATGGATTAAATGATGAAGAGAATGGTCAATTTAAG
    CATATGCACCGCCATAGTGCCACAATTGTTGGAGGCGCTTTAACTTTAGCAGATCTTATT
    ATGTCAGGCAAAGTATTAAATGGTTGTCACTTAGGTGGTGGTTTGCATCACGCTCAACCT
    GGTCGAGCAAGTGGTTTTTGTATATACAATGATATTGCAATTACCGCACAATACTTAGCT
    AAAGAATACAATCAACGCGTTTTAATCATAGATACCGATGCACATCATGGAGATGGTACA
    CAATGGAGTTTCTATGCCGATAACCATGTTACTACTTATTCTATCCATGAAACCGGAAAA
    TTTCTTTTCCCAGGCTCTGGTCACTATACTGAGCGCGGTGAAGATATCGGCTATGGACAC
    ACTGTAAATGTCCCACTTGAACCGTATACAGAAGATGCATCATTTTTGGAGTGTTTTAAA
    TTAACAGTTGAGCCTGTCGTAAAGAGTTTTAAACCTGATATTATTCTAAGCGTAAATGGT
    GTCGATATACATTATCGTGATCCACTAACTCATCTAAATTGTACGTTACATTCATTATAT
    GAAATTCCATATTTTGTAAAATATTTAGCTGATTCTTATACGAATGGAAAGGTAATTATG
    TTTGGTGGCGGAGGCTACAATATTTGGAGAGTCGTACCACGTGCATGGAGTCATGTATTC
    TTAAGTTTAATTGATCAACCAATTCAAAGTGGTTATTTACCGTTAGAATGGATTAATAAA
    TGGAAACATTATTCATCTGAATTATTACCTAAAAGATGGGAAGATCGTTTAAATGATTAT
    ACCTATGTCCCCCGCACAAAAGAAATTAGTGAAAAAAATAAAAAATTAGCTTTACATATA
    GCGAGTTGGTACGAATCTACTCGTCAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1170

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SACOL1785 [new locus tag: SACOL_RS09140 ]
  • symbol: AcuC
  • description: acetoin utilization protein AcuC
  • length: 389
  • theoretical pI: 6.79824
  • theoretical MW: 44629.1
  • GRAVY: -0.42365

⊟Function[edit | edit source]

  • TIGRFAM:
  • TheSEED  :
    • NAD-independent protein deacetylase AcuC
    Carbohydrates Central carbohydrate metabolism Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate  NAD-independent protein deacetylase AcuC
  • ⊞PFAM:
    Arginase (CL0302) Hist_deacetyl; Histone deacetylase domain (PF00850; HMM-score: 298)
    and 1 more
    no clan defined AbrB_C; AbrB C-terminal domain (PF18277; HMM-score: 11.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • ⊞DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.88
    • Cytoplasmic Membrane Score: 0.0486
    • Cell wall & surface Score: 0.0005
    • Extracellular Score: 0.0708
  • ⊞LocateP: Intracellular
    • Prediction by SwissProt Classification: Cytoplasmic
    • Pathway Prediction: No pathway
    • Intracellular possibility: 1
    • Signal peptide possibility: -1
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002487
    • TAT(Tat/SPI): 0.000189
    • LIPO(Sec/SPII): 0.00035
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MQQHSSKTAYVYSDKLLQYRFHDQHPFNQMRLKLTTELLLNANLLSPEQIVQPRIATDDELMLIHKYDYVEAIKHASHGIISEDEAKKYGLNDEENGQFKHMHRHSATIVGGALTLADLIMSGKVLNGCHLGGGLHHAQPGRASGFCIYNDIAITAQYLAKEYNQRVLIIDTDAHHGDGTQWSFYADNHVTTYSIHETGKFLFPGSGHYTERGEDIGYGHTVNVPLEPYTEDASFLECFKLTVEPVVKSFKPDIILSVNGVDIHYRDPLTHLNCTLHSLYEIPYFVKYLADSYTNGKVIMFGGGGYNIWRVVPRAWSHVFLSLIDQPIQSGYLPLEWINKWKHYSSELLPKRWEDRLNDYTYVPRTKEISEKNKKLALHIASWYESTRQ

⊟Experimental data[edit | edit source]

  • experimentally validated: PeptideAtlas
  • protein localization: Cytoplasmic [1]
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • ⊞regulators: CcpA regulon, CodY (repression) regulon

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Dörte Becher, Kristina Hempel, Susanne Sievers, Daniela Zühlke, Jan Pané-Farré, Andreas Otto, Stephan Fuchs, Dirk Albrecht, Jörg Bernhardt, Susanne Engelmann, Uwe Völker, Jan Maarten van Dijl, Michael Hecker
    A proteomic view of an important human pathogen--towards the quantification of the entire Staphylococcus aureus proteome.
    PLoS One: 2009, 4(12);e8176
    [PubMed:19997597] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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