NCBI: 02-MAR-2017

⊟Summary[edit | edit source]

organism: Staphylococcus aureus COL

locus tag: SACOL_RS04920 [old locus tag: SACOL0960 ]

pan locus tag^?: SAUPAN003059000

symbol: SACOL_RS04920

pan gene symbol^?: rocD

synonym:
product: Ornithine aminotransferase 2

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

type: CDS
locus tag: SACOL_RS04920 [old locus tag: SACOL0960 ]
symbol: SACOL_RS04920
product: Ornithine aminotransferase 2
replicon: chromosome
strand: +
coordinates: 961329..962519
length: 1191
essential: unknown other strains

⊟Accession numbers[edit | edit source]

Location: NC_002951 (961329..962519) NCBI
BioCyc: SACOL_RS04920 BioCyc
MicrobesOnline: see SACOL0960

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

1
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541
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1021
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1141
ATGACTAAATCTGAAAAAATTATTGAGTTAACAAATCATTACGGAGCACATAATTATTTA
CCATTGCCAATTGTCATTTCAGAAGCTGAAGGGGTATGGGTTAAAGATCCTGAAGGCAAT
AAATATATGGATATGTTATCTGCATATTCCGCTGTTAACCAAGGTCATAGACATCCGAAA
ATTATTCAAGCATTAAAAGATCAAGCTGATAAAGTGACTTTAGTTTCACGTGCTTTTCAT
AGTGATAACTTAGGTGAATGGTACGAAAAAATTTGTAAACTGGCAGGTAAAGATAAAGCT
TTACCAATGAATACAGGTGCTGAAGCAGTAGAAACAGCTTTGAAAGCAGCACGACGCTGG
GCATACGATGTTAAAGGAATTGAGCCAAATAAAGCAGAAATCATTGCATTTAATGGTAAC
TTCCATGGTCGAACAATGGCGCCAGTTTCATTATCTTCAGAAGCAGAATACCAACGTGGT
TATGGTCCGTTATTAGATGGATTTAGAAAAGTTGATTTTGGAGATGTAGATGCATTGAAA
GCTGCAATTAATGAAAATACTGCAGCAGTTTTAGTAGAACCAATTCAAGGTGAAGCGGGT
ATAAATATACCGCCAGAAGGATATTTGAAAGCAATTAGAGAATTATGTGATGAACATAAT
GTCTTATTTATTGCTGACGAAATCCAAGCAGGATTAGGTCGTTCGGGTAAATTATTTGCT
ACGGATTGGGATAATGTAAAACCTGATGTCTATATTTTAGGTAAAGCACTAGGTGGTGGA
GTCTTCCCAATTTCTGTTGTATTAGCAGATAAAGAAGTATTAGATGTCTTTACACCTGGC
TCACATGGTTCAACATTTGGTGGTAATCCACTTGCTTGTGCTGCATCAATTGCTGCATTA
GATGTTATCGTTGATGAGGATTTACCAGGCCGCTCTTTAGAATTAGGAGATTATTTTAAA
GAACAATTAAAGCAAATTGATCATCCATCAATTAAAGAAGTCCGTGGACGTGGTTTGTTT
ATAGGTGTGGAACTTAATGAAAGTGCTAGACCATATTGTGAAGCTTTGAAAGAAGAAGGC
TTATTATGTAAAGAAACGCATGATACTGTCATTCGTTTTGCACCACCATTAATTATTACT
AAAGAAGAATTGGACCTTGCACTTGAAAAAATAAGACATGTATTTCAATAA
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1191

⊟Protein[edit | edit source]

⊟General[edit | edit source]

locus tag: SACOL_RS04920 [old locus tag: SACOL0960 ]
symbol: SACOL_RS04920
description: Ornithine aminotransferase 2
length: 396
theoretical pI: 5.02774
theoretical MW: 43417.2
GRAVY: -0.183333

⊟Function[edit | edit source]

⊞⊞reaction:
EC 2.6.1.13? ExPASy
Ornithine aminotransferase L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid
⊞⊞TIGRFAM:
ornithine--oxo-acid transaminase (TIGR01885; EC 2.6.1.13; HMM-score: 538.4)
and 16 more
transaminase, acetylornithine/succinylornithine family (TIGR00707; HMM-score: 402)
Metabolism Energy metabolism Amino acids and amines succinylornithine transaminase family (TIGR03246; EC 2.6.1.81; HMM-score: 310.5)
Metabolism Central intermediary metabolism Polyamine biosynthesis putrescine aminotransferase (TIGR03372; EC 2.6.1.82; HMM-score: 256.2)
Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Biotin adenosylmethionine-8-amino-7-oxononanoate transaminase (TIGR00508; EC 2.6.1.62; HMM-score: 249.2)
Metabolism Central intermediary metabolism Other 4-aminobutyrate transaminase (TIGR00700; EC 2.6.1.19; HMM-score: 248.1)
Metabolism Central intermediary metabolism Other 2,4-diaminobutyrate 4-transaminase (TIGR00709; EC 2.6.1.-; HMM-score: 209.8)
Cellular processes Cellular processes Adaptations to atypical conditions diaminobutyrate--2-oxoglutarate aminotransferase (TIGR02407; EC 2.6.1.76; HMM-score: 188.8)
L-lysine 6-transaminase (TIGR03251; EC 2.6.1.36; HMM-score: 155.7)
Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin glutamate-1-semialdehyde-2,1-aminomutase (TIGR00713; EC 5.4.3.8; HMM-score: 143.3)
Metabolism Central intermediary metabolism Other 4-aminobutyrate aminotransferase (TIGR00699; EC 2.6.1.19; HMM-score: 107)
Genetic information processing Protein synthesis tRNA and rRNA base modification cysteine desulfurase IscS (TIGR02006; EC 2.8.1.7; HMM-score: 16.4)
Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other cysteine desulfurase IscS (TIGR02006; EC 2.8.1.7; HMM-score: 16.4)
cysteine desulfurase, NifS family (TIGR03403; EC 2.8.1.7; HMM-score: 15.6)
Metabolism Energy metabolism Amino acids and amines tyrosine aminotransferase (TIGR01264; EC 2.6.1.5; HMM-score: 15.1)
tyrosine/nicotianamine family aminotransferase (TIGR01265; HMM-score: 15)
cysteine desulfurase NifS (TIGR03402; EC 2.8.1.7; HMM-score: 11.8)
TheSEED: see SACOL0960
⊞⊞PFAM:
PLP_aminotran (CL0061) Aminotran_3; Aminotransferase class-III (PF00202; HMM-score: 460.3)
and 5 more
Aminotran_1_2; Aminotransferase class I and II (PF00155; HMM-score: 26.5)
DegT_DnrJ_EryC1; DegT/DnrJ/EryC1/StrS aminotransferase family (PF01041; HMM-score: 18.9)
KYNU_C; Kynureninase C-terminal domain (PF22580; HMM-score: 17.5)
Beta_elim_lyase; Beta-eliminating lyase (PF01212; HMM-score: 15.9)
Aminotran_5; Aminotransferase class-V (PF00266; HMM-score: 10.6)

⊟Structure, modifications & cofactors[edit | edit source]

domains:
modifications:
cofactors: pyridoxal 5'-phosphate
effectors:

⊟Localization[edit | edit source]

⊞⊞
PSORTb: Cytoplasmic
- Cytoplasmic Score: 9.97
- Cytoplasmic Membrane Score: 0
- Cellwall Score: 0.01
- Extracellular Score: 0.02
- Internal Helices: 0
⊞⊞
DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.9881
- Cytoplasmic Membrane Score: 0.0002
- Cell wall & surface Score: 0
- Extracellular Score: 0.0117
LocateP:
⊞⊞
SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.007347
- TAT(Tat/SPI): 0.00029
- LIPO(Sec/SPII): 0.000678
predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

GI: 446089459 NCBI
RefSeq: WP_000167314 NCBI
UniProt: see SACOL0960

⊟Protein sequence[edit | edit source]

MTKSEKIIELTNHYGAHNYLPLPIVISEAEGVWVKDPEGNKYMDMLSAYSAVNQGHRHPKIIQALKDQADKVTLVSRAFHSDNLGEWYEKICKLAGKDKALPMNTGAEAVETALKAARRWAYDVKGIEPNKAEIIAFNGNFHGRTMAPVSLSSEAEYQRGYGPLLDGFRKVDFGDVDALKAAINENTAAVLVEPIQGEAGINIPPEGYLKAIRELCDEHNVLFIADEIQAGLGRSGKLFATDWDNVKPDVYILGKALGGGVFPISVVLADKEVLDVFTPGSHGSTFGGNPLACAASIAALDVIVDEDLPGRSLELGDYFKEQLKQIDHPSIKEVRGRGLFIGVELNESARPYCEALKEEGLLCKETHDTVIRFAPPLIITKEELDLALEKIRHVFQ

⊟Experimental data[edit | edit source]

experimentally validated: see SACOL0960
protein localization: see SACOL0960
quantitative data / protein copy number per cell: see SACOL0960

⊟⊟interaction partners:

SACOL_RS02930		pyridoxal 5'-phosphate synthase lyase subunit PdxS ^[1] (data from MRSA252)
SACOL_RS03030		50S ribosomal protein L1 ^[1] (data from MRSA252)
SACOL_RS03080		elongation factor Tu ^[1] (data from MRSA252)
SACOL_RS04315		phosphoglycerate kinase ^[1] (data from MRSA252)
SACOL_RS04840		NADH dehydrogenase ^[1] (data from MRSA252)
SACOL_RS04980		hypothetical protein ^[1] (data from MRSA252)
SACOL_RS05635		pyruvate dehydrogenase E1 component subunit beta ^[1] (data from MRSA252)
SACOL_RS05640		dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex ^[1] (data from MRSA252)
SACOL_RS05645		dihydrolipoyl dehydrogenase ^[1] (data from MRSA252)
SACOL_RS06420		50S ribosomal protein L19 ^[1] (data from MRSA252)
SACOL_RS06505		30S ribosomal protein S2 ^[1] (data from MRSA252)
SACOL_RS08345		molecular chaperone DnaK ^[1] (data from MRSA252)
SACOL_RS08670		50S ribosomal protein L27 ^[1] (data from MRSA252)
SACOL_RS08680		50S ribosomal protein L21 ^[1] (data from MRSA252)
SACOL_RS08820		50S ribosomal protein L20 ^[1] (data from MRSA252)
SACOL_RS08905		isocitrate dehydrogenase (NADP(+)) ^[1] (data from MRSA252)
SACOL_RS08930		pyruvate kinase ^[1] (data from MRSA252)
SACOL_RS08995		universal stress protein UspA ^[1] (data from MRSA252)
SACOL_RS09045		30S ribosomal protein S4 ^[1] (data from MRSA252)
SACOL_RS11615		30S ribosomal protein S9 ^[1] (data from MRSA252)
SACOL_RS11655		30S ribosomal protein S11 ^[1] (data from MRSA252)
SACOL_RS11685		50S ribosomal protein L15 ^[1] (data from MRSA252)
SACOL_RS11695		30S ribosomal protein S5 ^[1] (data from MRSA252)
SACOL_RS11720		50S ribosomal protein L5 ^[1] (data from MRSA252)
SACOL_RS11765		50S ribosomal protein L2 ^[1] (data from MRSA252)
SACOL_RS12675		2,3-bisphosphoglycerate-dependent phosphoglycerate mutase ^[1] (data from MRSA252)
SACOL_RS13725		malate:quinone oxidoreductase ^[1] (data from MRSA252)
SACOL_RS13915		arginine deiminase ^[1] (data from MRSA252)

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

regulator: ArgR/AhrC, CcpA see SACOL0960

⊟Transcription pattern[edit | edit source]

S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

Aureolib: no data available

⊟Protein stability[edit | edit source]

half-life: no data available

⊞Biological Material[edit | edit source]

⊞Other Information[edit | edit source]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

↑ ^{Jump up to: 1.00} ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 ^1.19 ^1.20 ^1.21 ^1.22 ^1.23 ^1.24 ^1.25 ^1.26 ^1.27 Artem Cherkasov, Michael Hsing, Roya Zoraghi, Leonard J Foster, Raymond H See, Nikolay Stoynov, Jihong Jiang, Sukhbir Kaur, Tian Lian, Linda Jackson, Huansheng Gong, Rick Swayze, Emily Amandoron, Farhad Hormozdiari, Phuong Dao, Cenk Sahinalp, Osvaldo Santos-Filho, Peter Axerio-Cilies, Kendall Byler, William R McMaster, Robert C Brunham, B Brett Finlay, Neil E Reiner
Mapping the protein interaction network in methicillin-resistant Staphylococcus aureus.
J Proteome Res: 2011, 10(3);1139-50
[PubMed:21166474] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

[pubmed21166474-1] {Jump up to: 1.00} ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 ^1.19 ^1.20 ^1.21 ^1.22 ^1.23 ^1.24 ^1.25 ^1.26 ^1.27 Artem Cherkasov, Michael Hsing, Roya Zoraghi, Leonard J Foster, Raymond H See, Nikolay Stoynov, Jihong Jiang, Sukhbir Kaur, Tian Lian, Linda Jackson, Huansheng Gong, Rick Swayze, Emily Amandoron, Farhad Hormozdiari, Phuong Dao, Cenk Sahinalp, Osvaldo Santos-Filho, Peter Axerio-Cilies, Kendall Byler, William R McMaster, Robert C Brunham, B Brett Finlay, Neil E Reiner
Mapping the protein interaction network in methicillin-resistant Staphylococcus aureus.
J Proteome Res: 2011, 10(3);1139-50
[PubMed:21166474] [WorldCat.org] [DOI] (I p)

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⊟Summary[edit | edit source]

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

⊟DNA sequence[edit | edit source]

⊟Protein[edit | edit source]

⊟General[edit | edit source]

⊟Function[edit | edit source]

⊟Structure, modifications & cofactors[edit | edit source]

⊟Localization[edit | edit source]

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

⊟Experimental data[edit | edit source]

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

⊟Summary[edit | edit source]

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

⊟DNA sequence[edit | edit source]

⊟Protein[edit | edit source]

⊟General[edit | edit source]

⊟Function[edit | edit source]

⊟Structure, modifications & cofactors[edit | edit source]

⊟Localization[edit | edit source]

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

⊟Experimental data[edit | edit source]

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]