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⊟Summary[edit | edit source]

  • pan ID?: SAUPAN003315000
  • symbol?: def
  • synonym:
  • ⊟description?: peptide deformylase

      descriptions from strain specific annotations:

    • peptide deformylase
    • putative polypeptide deformylase 2
  • strand?: -
  • coordinates?: 3682725..3683276
  • synteny block?: BlockID0023990
  • occurrence?: in 100% of 34 strains

defB : peptide deformylase [1]

• A crystal structure is available : 1LMH

While all bacterial coding sequences initiate with a formyl-methionine, not all ribosomal proteins contain an N-terminal formyl-methionine. Staphylococci contain two peptide deformylase paralogues whereas most gram-negative bacteria contain only one. Although DefA more closely resembles the Class I peptide deformylase from gram-negative bacteria, it does not remove formate from proteins and its function is unknown. Only the Class II peptide deformylase DefB can remove formate from the N-terminal methionine residues of nascent proteins as they emerge from ribosomes.

⊟Orthologs[edit | edit source]

    COL:
    SACOL1100 (def)
    N315:
    SA0942 (def)
    NCTC8325:
    SAOUHSC_01038 (def)
    Newman:
    NWMN_0957 (def)
    USA300_FPR3757:
    SAUSA300_0991 (def)
    04-02981:
    SA2981_1048 (pdf1)
    08BA02176:
    C248_1118
    11819-97:
    MS7_1048
    6850:
    RSAU_000976 (def1)
    71193:
    ST398NM01_1088
    ECT-R 2:
    ECTR2_946 (def)
    ED133:
    SAOV_1035c
    ED98:
    SAAV_1056 (def)
    HO 5096 0412:
    SAEMRSA15_09210
    JH1:
    SaurJH1_1173 (def)
    JH9:
    SaurJH9_1151 (def)
    JKD6008:
    SAA6008_01046 (def)
    JKD6159:
    SAA6159_00947 (def)
    JSNZ:
    JSNZ_001056 (def)
    LGA251:
    SARLGA251_10040
    M013:
    M013TW_1023
    MRSA252:
    SAR1065 (def)
    MSHR1132:
    SAMSHR1132_09380
    MSSA476:
    SAS1026 (def)
    Mu3:
    SAHV_1083 (def)
    Mu50:
    SAV1091 (def)
    MW2:
    MW0974 (def)
    RF122:
    SAB0957c (def)
    ST398:
    SAPIG1088 (def)
    T0131:
    SAT0131_01128
    TCH60:
    HMPREF0772_12141 (def2)
    TW20:
    SATW20_10860
    USA300_TCH1516:
    USA300HOU_1034 (def)
    VC40:
    SAVC_04615 (def)

⊟Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

⊟Alignments[edit | edit source]

  • ⊞alignment of orthologues:

  1. ↑ P S Margolis, C J Hackbarth, D C Young, W Wang, D Chen, Z Yuan, R White, J Trias
    Peptide deformylase in Staphylococcus aureus: resistance to inhibition is mediated by mutations in the formyltransferase gene.
    Antimicrob Agents Chemother: 2000, 44(7);1825-31
    [PubMed:10858337] [WorldCat.org] [DOI] (P p)    Eric T Baldwin, Melissa S Harris, Anthony W Yem, Cindy L Wolfe, Anne F Vosters, Kimberly A Curry, Robert W Murray, Jeffrey H Bock, Vincent P Marshall, Joyce I Cialdella, Mahesh H Merchant, Gil Choi, Martin R Deibel
    Crystal structure of type II peptide deformylase from Staphylococcus aureus.
    J Biol Chem: 2002, 277(34);31163-71
    [PubMed:12048187] [WorldCat.org] [DOI] (P p)    Andrew N Keller, Xiao Yang, Jana Wiedermannová, Olivier Delumeau, Libor Krásný, Peter J Lewis
    ε, a new subunit of RNA polymerase found in gram-positive bacteria.
    J Bacteriol: 2014, 196(20);3622-32
    [PubMed:25092033] [WorldCat.org] [DOI] (I p)
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