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⊟Summary[edit | edit source]

  • pan ID?: SAUPAN001095000
  • symbol?: fadE
  • synonym:
  • ⊟description?: long-chain-fatty-acid--CoA ligase

      descriptions from strain specific annotations:

    • long-chain-fatty-acid--CoA ligase
    • acyl--CoA ligase
    • acyl-CoA synthetase, putative
    • acyl-CoA synthetase FadE
    • acyl-CoA synthetase FadE-like protein
    • class I adenylate-forming enzyme family protein
    • acyl-CoA synthetase
    • AMP-binding protein
    • AMP-dependent synthetase and ligase
    • long-chain acyl-CoA synthetase
    • long-chain-fatty-acid--CoA ligase, putative
    • o-succinylbenzoate--CoA ligase
    • putative acyl-CoA synthetase
  • strand?: -
  • coordinates?: 1371994..1373508
  • synteny block?: BlockID0006170
  • occurrence?: in 100% of 34 strains

fadD : long-chain fatty-acid:CoA ligase [1]

• long-chain fatty-acid:CoA ligase (alt. acyl-CoA synthetase, acyl-CoA ligase) sequesters (thioesterifies) free fatty acids onto coenzyme A. Typically FadD acts on long-chain saturated fatty acids for the β-oxidation pathway whereas long-chain unsaturated fatty acids are managed by the fakA phospholipid incorporation pathway.

*** Please note, most annotations have this enzyme misannotated as FadE. It is, in fact, FadD, the acyl:CoA ligase. The gene order in staphylococci is not alphabetical.***

⊟Orthologs[edit | edit source]

    COL:
    SACOL0214
    N315:
    SA0226
    NCTC8325:
    SAOUHSC_00198
    Newman:
    NWMN_0170 (fadE)
    USA300_FPR3757:
    SAUSA300_0228 (fadE)
    04-02981:
    SA2981_0234
    08BA02176:
    C248_0218 (fadE)
    11819-97:
    MS7_0220
    6850:
    RSAU_000179 (fadE)
    71193:
    ST398NM01_0244
    ECT-R 2:
    ECTR2_194
    ED133:
    SAOV_0171
    ED98:
    SAAV_0199
    HO 5096 0412:
    SAEMRSA15_01920 (fadE)
    JH1:
    SaurJH1_0224
    JH9:
    SaurJH9_0218
    JKD6008:
    SAA6008_00203
    JKD6159:
    SAA6159_00208
    JSNZ:
    JSNZ_000171
    LGA251:
    SARLGA251_01980 (fadE)
    M013:
    M013TW_0213
    MRSA252:
    SAR0226 (fadE)
    MSHR1132:
    SAMSHR1132_01990
    MSSA476:
    SAS0210
    Mu3:
    SAHV_0233
    Mu50:
    SAV0234
    MW2:
    MW0210
    RF122:
    SAB0173c
    ST398:
    SAPIG0244
    T0131:
    SAT0131_00221
    TCH60:
    HMPREF0772_10271 (menE)
    TW20:
    SATW20_02350 (fadE)
    USA300_TCH1516:
    USA300HOU_0243
    VC40:
    SAVC_00910

⊟Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

⊟Alignments[edit | edit source]

  • ⊞alignment of orthologues:

  1. ↑ Joshua R Fletcher, Alex R Villareal, Mitchell R Penningroth, Ryan C Hunter
    Staphylococcus aureus Overcomes Anaerobe-Derived Short-Chain Fatty Acid Stress via FadX and the CodY Regulon.
    J Bacteriol: 2022, 204(5);e0006422
    [PubMed:35389253] [WorldCat.org] [DOI] (I p)    Robert C Kuiack, Stephen W Tuffs, Karine Dufresne, Robert Flick, John K McCormick, Martin J McGavin
    The fadXDEBA locus of Staphylococcus aureus is required for metabolism of exogenous palmitic acid and in vivo growth.
    Mol Microbiol: 2023, 120(3);425-438
    [PubMed:37501506] [WorldCat.org] [DOI] (I p)
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