From AureoWiki
Revision as of 03:09, 20 December 2024 by Adberti (talk | contribs)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search

⊟Summary[edit | edit source]

  • pan ID?: SAUPAN004250000
  • symbol?: obgE
  • synonym:
  • ⊟description?: GTPase ObgE

      descriptions from strain specific annotations:

    • GTPase ObgE
    • Spo0B-related GTP-binding protein
    • GTPase CgtA
    • GTP-binding protein CgtA
    • GTP-binding protein Obg
    • GTP-binding protein Obg/CgtA
    • obg family GTPase CgtA
    • Spo0B-associated GTP-binding protein
  • strand?: -
  • coordinates?: 4497050..4498342
  • synteny block?: BlockID0032780
  • occurrence?: in 100% of 34 strains

obgE (cgtA): 70S ribosome anti-association factor and ribosome-associated GTPase ObgE [1]

Ribosome-associated GTPases including Era, RsgA, RbgA, HflX, ObgE, EngA and EngB are widely-conserved, stringent response alarmone-responsive ribosomal assembly cofactors

• ObgE displays transient 50S subunit binding and may act as a 70S anti-association factor checkpoint. Alarmone binding increases 50S affinity resulting in sequestration of large ribosome subunits and functional ribosome depletion.

⊟Orthologs[edit | edit source]

    COL:
    SACOL1699 (obgE)
    N315:
    SA1470 (obgE)
    NCTC8325:
    SAOUHSC_01753 (obgE)
    Newman:
    NWMN_1546 (obgE)
    USA300_FPR3757:
    SAUSA300_1600 (obgE)
    04-02981:
    SA2981_1602 (obg)
    08BA02176:
    C248_1687 (obg)
    11819-97:
    MS7_1659 (cgtA)
    6850:
    RSAU_001505 (obgE)
    71193:
    ST398NM01_1707
    ECT-R 2:
    ECTR2_1492
    ED133:
    SAOV_1641
    ED98:
    SAAV_1637 (obgE)
    HO 5096 0412:
    SAEMRSA15_15610 (obg)
    JH1:
    SaurJH1_1734 (obgE)
    JH9:
    SaurJH9_1701 (obgE)
    JKD6008:
    SAA6008_01613 (obgE)
    JKD6159:
    SAA6159_01576 (obgE)
    JSNZ:
    JSNZ_001634 (obgE)
    LGA251:
    SARLGA251_15460 (obg)
    M013:
    M013TW_1664
    MRSA252:
    SAR1724 (obgE)
    MSHR1132:
    SAMSHR1132_14800
    MSSA476:
    SAS1580 (obgE)
    Mu3:
    SAHV_1631 (obgE)
    Mu50:
    SAV1644 (obgE)
    MW2:
    MW1594 (obgE)
    RF122:
    SAB1513c (obgE)
    ST398:
    SAPIG1707
    T0131:
    SAT0131_01744 (atoB)
    TCH60:
    HMPREF0772_11498 (cgtA)
    TW20:
    SATW20_16380 (obg)
    USA300_TCH1516:
    USA300HOU_1643 (obgE)
    VC40:
    SAVC_07465 (obgE)

⊟Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

⊟Alignments[edit | edit source]

  • ⊞alignment of orthologues:

  1. ↑ Boya Feng, Chandra Sekhar Mandava, Qiang Guo, Jie Wang, Wei Cao, Ningning Li, Yixiao Zhang, Yanqing Zhang, Zhixin Wang, Jiawei Wu, Suparna Sanyal, Jianlin Lei, Ning Gao
    Structural and functional insights into the mode of action of a universally conserved Obg GTPase.
    PLoS Biol: 2014, 12(5);e1001866
    [PubMed:24844575] [WorldCat.org] [DOI] (I e)    Rebecca M Corrigan, Lauren E Bellows, Alison Wood, Angelika Gründling
    ppGpp negatively impacts ribosome assembly affecting growth and antimicrobial tolerance in Gram-positive bacteria.
    Proc Natl Acad Sci U S A: 2016, 113(12);E1710-9
    [PubMed:26951678] [WorldCat.org] [DOI] (I p)
Retrieved from "http://fungenwikiserver.biologie.uni-greifswald.de/aureowiki/index.php?title=SAUPAN004250000&oldid=104219"