PangenomeCOLN315NCTC8325NewmanUSA300_FPR3757JSNZ04-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 02-MAR-2017

⊟Summary

• organism: Staphylococcus aureus N315
• locus tag: SA_RS09420 [old locus tag: SA1667 ]
• pan locus tag^?: SAUPAN004782000
• symbol: SA_RS09420
• pan gene symbol^?: airS
• synonym:
• product: sensor histidine kinase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SA_RS09420 [old locus tag: SA1667 ]
• symbol: SA_RS09420
• product: sensor histidine kinase
• replicon: chromosome
• strand: -
• coordinates: 1902970..1904082
• length: 1113
• essential: no DEG other strains

⊟Accession numbers

• Location: NC_002745 (1902970..1904082) NCBI
• BioCyc: SA_RS09420 BioCyc
• MicrobesOnline: see SA1667

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
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  1021
  1081
  
  ATGGAACAAAGGACGCGACTAGCTTTATTAAAAGAGATTGCCGAATTTTTAAACGAAGAA
  ACTGAAATGTATAGCATGACCCAAGGTGCGTTAAAATATTTAATTGAGGGCAGTAATTTC
  ACGACAGGCTGGATATTTTTCATCAATAGCGTAGGTGAACATGAACTTGTATCACATGTG
  GCTCTACCACAATCTTTGACAGCAGACCACTGTCACTATATTAAAGATGGGTCTTGTTGG
  TGTGTGAAAGCATTTAATCAACGTAGGCTAATGAAAGCGTCGAATATCGTCAATTGTTCT
  CGTATTAACTTAGCCTCTAAAGCATTTCCTAGCCAAAATGACAATATTACACATCATGCA
  ACGGTACCACTTAAATCGGGTCAAGAACAATTCGGCATTTTAAATGTAGCGTCCCCAAAT
  ACTGAAATATATAGTGATGAAGATTTAGAGTTGCTAGAGTCTGTCGCATTTCAATTAGGG
  TCAGCCATCAAACGTATTTATTTAACAGACCGTGAAAAAGAAGCAGCAAAAATTAATGAA
  CGTAATCGTTTAGCTAGAGATTTACATGATTCAGTAAATCAAATGTTATTTTCTGTAAAA
  CTAACAGCACATGCTGCGTATGGCATGTCAAACGAATCCATCGCTAAACAAGCATTCAAG
  ACGATTGAGAAAACGAGTCAAAATGCCGTTAATGAAATGCGTGCATTGATTTGGCAACTT
  AAGCCAGTTGGACTTGAGCAAGGTTTAATTCATGCTTTGACAGCATATAGTAAATTAATG
  CATATACAATTAAATGTAAATGTAGAAGGTTTAATCGATTTATCTAATGAAATCGAAGAA
  AACATATATAGAGCATTACAAGAGTGTATTAATAATGTTAAGAAACATGCTGATACGAAT
  AAAATGGATCTTACATTAAAACAAATGAACGATATACTATATATTGACGTGATTGATTAT
  GGTCAAGGATTTGAGATCGATAATGTTCAGATAGCTTCATCACACGGTATTAATAACATA
  AAACAAAGAGTTAAATTATTAAGAGGTAAAGTGACCTTTCATTCTCAGCCAACAAAGGGT
  ACACAAATACAATTCACAATTCCTATAAAATAG
  60
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  1113
  

⊟Protein

⊟General

• locus tag: SA_RS09420 [old locus tag: SA1667 ]
• symbol: SA_RS09420
• description: sensor histidine kinase
• length: 370
• theoretical pI: 6.9966
• theoretical MW: 41879.6
• GRAVY: -0.294865

⊟Function

• TIGRFAM:
  Genetic information processing Protein fate Protein and peptide secretion and trafficking putative PEP-CTERM system histidine kinase (TIGR02916; EC 2.7.13.3; HMM-score: 34.7)
  Signal transduction Signal transduction Two-component systems putative PEP-CTERM system histidine kinase (TIGR02916; EC 2.7.13.3; HMM-score: 34.7)
  and 3 more
  Metabolism Central intermediary metabolism Nitrogen fixation Nif-specific regulatory protein (TIGR01817; HMM-score: 26)
  Signal transduction Regulatory functions DNA interactions Nif-specific regulatory protein (TIGR01817; HMM-score: 26)
  anti-sigma B factor (TIGR01924; EC 2.7.11.1; HMM-score: 12.6)
• TheSEED: see SA1667
• PFAM:
  His_Kinase_A (CL0025) HisKA_3; Histidine kinase (PF07730; HMM-score: 65.3)
  GAF (CL0161) GAF_2; GAF domain (PF13185; HMM-score: 54.5)
  and 5 more
  His_Kinase_A (CL0025) HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518; HMM-score: 38.4)
  GAF (CL0161) GAF; GAF domain (PF01590; HMM-score: 34.7)
  GAF_3; GAF domain (PF13492; HMM-score: 31.6)
  no clan defined Flu_M1_C; Influenza Matrix protein (M1) C-terminal domain (PF08289; HMM-score: 13.5)
  His_Kinase_A (CL0025) HATPase_c_2; Histidine kinase-like ATPase domain (PF13581; HMM-score: 12.3)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic Membrane
  • Cytoplasmic Score: 1.05
  • Cytoplasmic Membrane Score: 8.78
  • Cellwall Score: 0.08
  • Extracellular Score: 0.09
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.8634
  • Cytoplasmic Membrane Score: 0.1351
  • Cell wall & surface Score: 0.0005
  • Extracellular Score: 0.001
• LocateP:
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.001431
  • TAT(Tat/SPI): 0.000468
  • LIPO(Sec/SPII): 0.000194
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI: 446360114 NCBI
• RefSeq: WP_000437969 NCBI
• UniProt: see SA1667

⊟Protein sequence

• MEQRTRLALLKEIAEFLNEETEMYSMTQGALKYLIEGSNFTTGWIFFINSVGEHELVSHVALPQSLTADHCHYIKDGSCWCVKAFNQRRLMKASNIVNCSRINLASKAFPSQNDNITHHATVPLKSGQEQFGILNVASPNTEIYSDEDLELLESVAFQLGSAIKRIYLTDREKEAAKINERNRLARDLHDSVNQMLFSVKLTAHAAYGMSNESIAKQAFKTIEKTSQNAVNEMRALIWQLKPVGLEQGLIHALTAYSKLMHIQLNVNVEGLIDLSNEIEENIYRALQECINNVKKHADTNKMDLTLKQMNDILYIDVIDYGQGFEIDNVQIASSHGINNIKQRVKLLRGKVTFHSQPTKGTQIQFTIPIK

⊟Experimental data

• experimentally validated: data available for COL, NCTC8325
• protein localization: data available for COL
• quantitative data / protein copy number per cell:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications