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NCBI: 02-MAR-2017

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus N315
  • locus tag: SA_RS06715 [old locus tag: SA1181 ]
  • pan locus tag?: SAUPAN003722000
  • symbol: SA_RS06715
  • pan gene symbol?: sbcC
  • synonym:
  • product: nuclease SbcCD subunit C

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SA_RS06715 [old locus tag: SA1181 ]
  • symbol: SA_RS06715
  • product: nuclease SbcCD subunit C
  • replicon: chromosome
  • strand: +
  • coordinates: 1343030..1346059
  • length: 3030
  • essential: no DEG other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_002745 (1343030..1346059) NCBI
  • BioCyc: SA_RS06715 BioCyc
  • MicrobesOnline: see SA1181

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    2881
    2941
    3001
    ATGAAACCATTACATTTAAAGTTGAATAATTTCGGCCCCTTTTTAAAAGAAGAAATTGAT
    TTTTCTAAAATTGATAATAATGAATTGTTTTTAATAAGTGGTAAGACTGGATCGGGTAAA
    ACAATGATTTTTGATGCAATGACTTATGCCTTGTTTGGTAAAGCATCAACTGAACAAAGA
    GAAGAAAATGATTTGAGAAGTCATTTCGCTGATGGTAAACAGCCGATGTCAGTAACATTT
    GAATTTCAATTAAATCATCGAATTTATAAAGTGCATAGACAAGGCCCTTATATCAAAGAA
    GGTAATACAACAAAAACGAACGCTAAATTTGATGTATTTGAGATGGTGGATGGCAAGTAT
    GAAATTAGAGAAAGTAAAGTAATTTCAGGTACCCAATTCATTATTGAATTATTAGGAGTA
    AATGCAGATCAATTCCGACAATTGTTTATTTTGCCTCAAGGTGAATTCAAACGCTTTTTA
    ATATCAAACAGTCGTGAAAAGCAAGGGATATTAAGAACACTGTTTGACAGTGAAAAATTT
    GAAGCTATACGAGAAATATTAAAAGAAGAACTAAAAAAAGAAAAAGCTCAAATCGAGAAT
    AGATATCAACAAATTGACCTTTTATGGCAAGAAATTGAATCATTTGATGATGACAAAATA
    AAAGGCTTATTAGAGCTTGCCACTCAGCAGATAGACAAATTGATTGAAAATATACCACTT
    TTACAAGCTAGGTCGAAAGAAATACTAGCATTTGTAAATGAAAGTAAAGAAACTGCTATT
    AAAGAATATGAAATAATAGAAAAGAAAACACTAGAAAATAATATATTAAAAGATAATATT
    AACCAACTCAACAAAAATAAAATTGATTTCGTTCAATTGAAAGAGCAACAACCTGAAATA
    GACGAAATTGAAGCTAAGTTAAAGTTGTTACAAGATATTACCAACCTATTGAATTATATT
    GAAAATAGAGAAAAAATTGAAACTAAAATTGCTAATAGCAAAAAAGATATTTCTAAAACC
    AATAATAAAATATTGAATCTTGATTGTGATAAGCGAAACATAGACAAAGAGAAAAAAATG
    TTAGAAGAAAACGGAGATTTAATTGAAAGTAAAACCTCTTTTATTGATAAAACTAGAGTA
    TTATTTAACGATATTAATAAGTATCAACAAAGTTATCTCAATATTGAATGCTTGATAACT
    GAGGGTGAACAATTAGGTGATGAATTAAATAATCTAATTAAAGGTTTAGAAAAGGTCGAA
    GATTCAATAGGTAATAACGAAAGTGATTACGAGAAAATTATCGAACTAAATAATGCGATA
    ACTAACATAAATAATGAAATTAATATAATTAAAGAAAATGAAAAAGCTAAAGCTGAATTA
    GATAAACTATTAGGTAGTAAGCAAGAGTTAGAGAATCAAATTAATGAAGAAACAACTATA
    ATGAAGAATCTCGAAATAAAATTAGATCACTACGATAAATCAAAATTGGACTTAAATGAT
    AAAGAAAGCTTTATAAGTGAAATTAAATCTGCTGTAAAGATTGGAGATCAATGTCCGATA
    TGTGGTAATGAAATTCAGGATTTAGGGCATCATATTGATTTTGACAGTATTGCTAAACGT
    CAAAATGAAATTAAAGAAATTGAAGCAAATATCCACGCAATAAAATCGAATATTGCTGTG
    CATAATTCTGAAATTAAATTTGTTAATGAAAAAATATCGAATATTAATATTAAAACGCAA
    AGTGATTTTTCACTCGAAGTATTGAATAAGCGTCTGCTAGAAAATGAAAATGCATTGAAT
    AATCAAAGAGATCTTAATAAATTTATAGAACAAATGAAAGAAGAAAAAGATAATCTAACG
    TTGCAAATTCATAATAAACAATTGCGTCTAAATAAAAATGAATCTGAGTTGAAATTATGT
    CGAGATCTCATCACTGAATTTGAAACACTCTCGAAATATAATAATATCACTAATTTTGAG
    GTGGATTATAAGAAGTATGTTCAAGATGTGAATCAGCATCAAGAACTCTCAAAGGAGATT
    GAAGATAAGTTAATGCAATTGTCTCAAAGAAAGTTAATTGAGCAAAATAATCTAAATCAC
    TATGAAAATCAACTAGAAACTTACAATAATGACTTAGAATTGAATGAACAATCTATTGAA
    ATGGAAATGTCGAGGCTGAATTTAACTGACGACAATGATATAAATGAAATAATAGCCTGG
    AGGGGCGAGCAAGAGGAATTAGAGCAGAAAAGGGATACTTATAAAAAACGTTATCATGAA
    TTTGAAATGGAAATAGCTAGGTTAGAATCATTAACCAAGGATAAAGAGTTATTGGACTCT
    GATAAATTAAAAGATGAATATGAGCAAAAAAAAGAAAAGATGAATACACTGATAGATGAA
    TACTCTGCTGTTCATTATCAATGTCAAAATAATATTAATAAAACACAATCTATAGTTTCG
    CATATTAATTACTTAAATCAAGAATTAAAGGATCAACAAGAAATTTTTCAATTGGCTGAA
    ATTGTCAGTGGTAAGAATAACAAAAATCTTACATTGGAAAACTTTGTCTTAATTTACTAT
    TTAGATCAAATTATTGCCCAAGCAAATCTGAGATTAGCAACAATGTCAGATAATCGATAC
    CAACTAATTAGGCGAGAAGCGGTTTCTCATGGTCTTAGTGGCCTAGAAATTGATGTATTT
    GATTTGCATTCAAATAAGTCTAGACATATTAGCTCGTTATCAGGTGGAGAAACTTTCCAA
    TCGTCGCTTGCATTAGCTTTAGGGTTAAGCGAAATTGTACAGCAGCAATCAGGAGGTATT
    TCACTAGAATCAATATTTATTGATGAAGGATTCGGTACATTAGATCAAGAAACGCTTGAA
    ACAGCGTTAGACACTTTATTAAATCTTAAATCAACTGGTAGAATGGTTGGGATTATTTCA
    CATGTGAGCGAATTGAAAAATAGAATACCTTTAGTTTTAGAAGTGAAATCAGATCAATAT
    CAGAGTTCAACAAGATTCAAAAGAAATTAA
    60
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    840
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    1560
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    2160
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    2700
    2760
    2820
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    2940
    3000
    3030

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SA_RS06715 [old locus tag: SA1181 ]
  • symbol: SA_RS06715
  • description: nuclease SbcCD subunit C
  • length: 1009
  • theoretical pI: 4.80676
  • theoretical MW: 117481
  • GRAVY: -0.706343

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing DNA metabolism DNA replication, recombination, and repair exonuclease SbcC (TIGR00618; HMM-score: 258.5)
    and 7 more
    Genetic information processing DNA metabolism Restriction/modification DNA sulfur modification protein DndD (TIGR03185; HMM-score: 30.7)
    Cellular processes Cellular processes Cell division cell division ATP-binding protein FtsE (TIGR02673; HMM-score: 18.1)
    Cellular processes Cellular processes Cell division chromosome segregation protein SMC (TIGR02169; HMM-score: 16.9)
    Genetic information processing DNA metabolism Chromosome-associated proteins chromosome segregation protein SMC (TIGR02169; HMM-score: 16.9)
    Cellular processes Cellular processes Cell division chromosome segregation protein SMC (TIGR02168; HMM-score: 7.7)
    Genetic information processing DNA metabolism Chromosome-associated proteins chromosome segregation protein SMC (TIGR02168; HMM-score: 7.7)
    type III secretion protein HrpB7 (TIGR02559; HMM-score: 7.5)
  • TheSEED: see SA1181
  • PFAM:
    P-loop_NTPase (CL0023) AAA_23; AAA domain (PF13476; HMM-score: 94.3)
    and 7 more
    SbcCD_C; Putative exonuclease SbcCD, C subunit (PF13558; HMM-score: 49.3)
    AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 29.1)
    AAA_27; AAA domain (PF13514; HMM-score: 25.8)
    SMC_N; RecF/RecN/SMC N terminal domain (PF02463; HMM-score: 16.4)
    DEAD; DEAD/DEAH box helicase (PF00270; HMM-score: 13.4)
    no clan defined MT0933_antitox; MT0933-like antitoxin protein (PF14013; HMM-score: 8.8)
    DUF3090; Protein of unknown function (DUF3090) (PF11290; HMM-score: 6.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.008049
    • TAT(Tat/SPI): 0.001824
    • LIPO(Sec/SPII): 0.000309
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKPLHLKLNNFGPFLKEEIDFSKIDNNELFLISGKTGSGKTMIFDAMTYALFGKASTEQREENDLRSHFADGKQPMSVTFEFQLNHRIYKVHRQGPYIKEGNTTKTNAKFDVFEMVDGKYEIRESKVISGTQFIIELLGVNADQFRQLFILPQGEFKRFLISNSREKQGILRTLFDSEKFEAIREILKEELKKEKAQIENRYQQIDLLWQEIESFDDDKIKGLLELATQQIDKLIENIPLLQARSKEILAFVNESKETAIKEYEIIEKKTLENNILKDNINQLNKNKIDFVQLKEQQPEIDEIEAKLKLLQDITNLLNYIENREKIETKIANSKKDISKTNNKILNLDCDKRNIDKEKKMLEENGDLIESKTSFIDKTRVLFNDINKYQQSYLNIECLITEGEQLGDELNNLIKGLEKVEDSIGNNESDYEKIIELNNAITNINNEINIIKENEKAKAELDKLLGSKQELENQINEETTIMKNLEIKLDHYDKSKLDLNDKESFISEIKSAVKIGDQCPICGNEIQDLGHHIDFDSIAKRQNEIKEIEANIHAIKSNIAVHNSEIKFVNEKISNINIKTQSDFSLEVLNKRLLENENALNNQRDLNKFIEQMKEEKDNLTLQIHNKQLRLNKNESELKLCRDLITEFETLSKYNNITNFEVDYKKYVQDVNQHQELSKEIEDKLMQLSQRKLIEQNNLNHYENQLETYNNDLELNEQSIEMEMSRLNLTDDNDINEIIAWRGEQEELEQKRDTYKKRYHEFEMEIARLESLTKDKELLDSDKLKDEYEQKKEKMNTLIDEYSAVHYQCQNNINKTQSIVSHINYLNQELKDQQEIFQLAEIVSGKNNKNLTLENFVLIYYLDQIIAQANLRLATMSDNRYQLIRREAVSHGLSGLEIDVFDLHSNKSRHISSLSGGETFQSSLALALGLSEIVQQQSGGISLESIFIDEGFGTLDQETLETALDTLLNLKSTGRMVGIISHVSELKNRIPLVLEVKSDQYQSSTRFKRN

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell: data available for COL
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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