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⊟Summary[edit | edit source]
- pan ID?: SAUPAN006450000
- symbol?: bstA
- synonym:
- description?: DinB family protein
- DinB family protein
- bacillithiol transferase BstA
- dinB superfamily protein
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 6493653..6494136
- synteny block?: BlockID0051570
- occurrence?: in 100% of 34 strains
bstA (dinB) : bacillithiol S-transferase [1]
• A crystal structure is available : 5WK0
The bacillithiol S-transferase enzyme (BstA) catalyzes the transfer of bacillithiol to free thiols. It has been characterized in the conjugation of bacillithiol to small molecule substrates, protecting the cell from antibiotics and other reactive compounds ; its role in protecting cellular proteins directly through bacillithiolation is unclear. Furthermore, highly electrophilic thiol substrates may be able to conjugate bacillithiol without BstA mediating the interaction.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2633
08BA02176:
C248_2757
11819-97:
MS7_2699
6850:
RSAU_002538
71193:
ST398NM01_2739
ECT-R 2:
ECTR2_2546
ED133:
SAOV_2737
ED98:
SAAV_2766
HO 5096 0412:
SAEMRSA15_25920
JH1:
SaurJH1_2774
JH9:
SaurJH9_2717
JKD6008:
SAA6008_02750
JKD6159:
SAA6159_02588
JSNZ:
JSNZ_002682 (bstA)
LGA251:
SARLGA251_24590
M013:
M013TW_2676
MRSA252:
SAR2773
MSHR1132:
SAMSHR1132_25220
MSSA476:
SAS2577
Mu3:
SAHV_2677
Mu50:
SAV2693
MW2:
MW2611
RF122:
SAB2569
ST398:
SAPIG2739
T0131:
SAT0131_02970
TCH60:
HMPREF0772_10495
TW20:
SATW20_28280
USA300_TCH1516:
USA300HOU_2695
VC40:
SAVC_12340
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MTTKTVFDVIDMGLGYLVNVYDAWKVEKVLDDYHKPFSNTIHWQFGHVLTIFESALAVAG
N315 MTTKTVFDVIDMGLGYLVNVYDAWKVEKVLDDYHEPFSNTIHWQFGHVLTIFESALAVAG
NCTC8325 MTTKTVFDVIDMGLGYLVNVYDAWKVEKVLDDYHKPFSNTIHWQFGHVLTIFESALAVAG
Newman MTTKTVFDVIDMGLGYLVNVYDAWKVEKVLDDYHKPFSNTIHWQFGHVLTIFESALAVAG
USA300_FPR3757 MTTKTVFDVIDMGLGYLVNVYDAWKVEKVLDDYHKPFSNTIHWQFGHVLTIFESALAVAG
**********************************:*************************
COL KENIDLNIYRPLFGNGSSPDEWKDEVPSIERILEGLQTLPERARNLTEDDLAIELKQPIV
N315 KENIDLNIYRPLFGNGSSPDEWKDEVPSIEKILEGLQTLPERARNLTEDDLAIELKQPIV
NCTC8325 KENIDLNIYRPLFGNGSSPDEWKDEVPSIERILEGLQTLPERARNLTEDDLAIELKQPIV
Newman KENIDLNIYRPLFGNGSSPDEWKDEVPSIERILEGLQTLPERARNLTEDDLAIELKQPIV
USA300_FPR3757 KENIDLNIYRPLFGNGSSPDEWKDEVPSIERILEGLQTLPERARNLTEDDLAIELKQPIV
******************************:*****************************
COL GCNNLEELLVLNAIHIPLHAGKIEEMSRILKNLK
N315 GCNNLEELLVLNAIHIPLHAGKIEEMSRILKNLK
NCTC8325 GCNNLEELLVLNAIHIPLHAGKIEEMSRILKNLK
Newman GCNNLEELLVLNAIHIPLHAGKIEEMSRILKNLK
USA300_FPR3757 GCNNLEELLVLNAIHIPLHAGKIEEMSRILKNLK
**********************************
- ↑ Arishma Rajkarnikar, Andrew Strankman, Shayla Duran, Derek Vargas, Alexandra A Roberts, Kathryn Barretto, Heather Upton, Christopher J Hamilton, Mamta Rawat
Analysis of mutants disrupted in bacillithiol metabolism in Staphylococcus aureus.
Biochem Biophys Res Commun: 2013, 436(2);128-33
[PubMed:23618856] [WorldCat.org] [DOI] (I p)Varahenage R Perera, Gerald L Newton, Jonathan M Parnell, Elizabeth A Komives, Kit Pogliano
Purification and characterization of the Staphylococcus aureus bacillithiol transferase BstA.
Biochim Biophys Acta: 2014, 1840(9);2851-61
[PubMed:24821014] [WorldCat.org] [DOI] (P p)Varahenage R Perera, Gerald L Newton, Kit Pogliano
Bacillithiol: a key protective thiol in Staphylococcus aureus.
Expert Rev Anti Infect Ther: 2015, 13(9);1089-107
[PubMed:26184907] [WorldCat.org] [DOI] (I p)Joel W Francis, Christopher J Royer, Paul D Cook
Structure and function of the bacillithiol-S-transferase BstA from Staphylococcus aureus.
Protein Sci: 2018, 27(4);898-902
[PubMed:29417696] [WorldCat.org] [DOI] (I p)