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⊟Summary[edit | edit source]
- pan ID?: SAUPAN006295000
- symbol?: budA2
- synonym:
- description?: alpha-acetolactate decarboxylase
- alpha-acetolactate decarboxylase
- acetolactate decarboxylase
- putative alpha-acetolactate decarboxylase
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 6343238..6343942
- synteny block?: BlockID0050110
- occurrence?: in 97% of 34 strains
budA2 (aldC2, alsD2) : acetolactate decarboxylase [1]
• A crystal structure is available : 1XV2
Staphylococcus aureus encodes two acetolactate decarboxylases. This version, BudA2, is the typical acid-labile version often associated with de novo branched-chain amino acid biosynthesis. While the typical nomenclature for this version is "budA" and the acidificiation bypass paralogue is "alsD", we are appending the "2" numeral here for additional clarity due to inconsistent nomenclature use in existing sequenced genomes.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2539
08BA02176:
C248_2660
11819-97:
MS7_2606
6850:
RSAU_002442 (budA)
71193:
ST398NM01_2649
ECT-R 2:
ECTR2_2455 (budA)
ED133:
SAOV_2645c
ED98:
SAAV_2667 (budA2)
HO 5096 0412:
SAEMRSA15_25040
JH1:
SaurJH1_2677
JH9:
SaurJH9_2623
JKD6008:
SAA6008_02658 (budA2)
JKD6159:
SAA6159_02497 (budA2)
JSNZ:
JSNZ_002582 (budA)
LGA251:
SARLGA251_23740
M013:
M013TW_2578
MRSA252:
SAR2679
MSHR1132:
SAMSHR1132_24160
MSSA476:
SAS2486
Mu3:
SAHV_2585
Mu50:
SAV2601
MW2:
MW2520
RF122:
SAB2474c
ST398:
SAPIG2649 (budA)
T0131:
SAT0131_02833
TCH60:
HMPREF0772_10591 (budA)
TW20:
SATW20_27400
USA300_TCH1516:
—
VC40:
SAVC_11875
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MTNVLYQHGTLGTLMAGLLEGTATINELLEHGNLGIATLTGSDGEVIFLDGKAYHANEHK
N315 MTNVLYQHGTLGTLMAGLLEGTATINELLEHGNLGIATLTGSDGEVIFLDGKAYHANEHK
NCTC8325 MTNVLYQHGTLGTLMAGLLEGTATINELLEHGNLGIATLTGSDGEVIFLDGKAYHANEHK
Newman MTNVLYQHGTLGTLMAGLLEGTATINELLEHGNLGIATLTGSDGEVIFLDGKAYHANEHK
USA300_FPR3757 MTNVLYQHGTLGTLMAGLLEGTATINELLEHGNLGIATLTGSDGEVIFLDGKAYHANEHK
************************************************************
COL EFIELKGDEKVPYASITNFKASKTFPLQQLSQDDVFAQIKNEMLSENLFSAVKIYGTFKH
N315 EFIELKGDEKVPYASITNFKASKTFPLQQLSQDDVFAQIKNEMLSENLFSAVKIYGTFKH
NCTC8325 EFIELKGDEKVPYASITNFKASKTFPLQQLSQDDVFAQIKNEMLSENLFSAVKIYGTFKH
Newman EFIELKGDEKVPYASITNFKASKTFPLQQLSQDDVFAQIKNEMLSENLFSAVKIYGTFKH
USA300_FPR3757 EFIELKGDEKVPYASITNFKASKTFPLQQLSQDDVFAQIKNEMLSENLFSAVKIYGTFKH
************************************************************
COL MHVRMMPAQQPPYTRLIDSARRQPEEKRQDIRGAIVGFFTPELFHGVGSAGFHIHFADDE
N315 MHVRMMPAQQPPYTRLIDSARRQPEEKRQDIRGAIVGFFTPELFHGVGSAGFHIHFADDE
NCTC8325 MHVRMMPAQQPPYTRLIDSARRQPEEKRQDIRGAIVGFFTPELFHGVGSAGFHIHFADDE
Newman MHVRMMPAQQPPYTRLIDSARRQPEEKRQDIRGAIVGFFTPELFHGVGSAGFHIHFADDE
USA300_FPR3757 MHVRMMPAQQPPYTRLIDSARRQPEEKRQDIRGAIVGFFTPELFHGVGSAGFHIHFADDE
************************************************************
COL RAYGGHVLDFEVDDVVVEIQNFETFQQHFPVNNETFVKAKIDYNDVAEEIREAE
N315 RAYGGHVLDFEVDDVVVEIQNFETFQQHFPVNNETFVKAKIDYKDVAEEIREAE
NCTC8325 RAYGGHVLDFEVDDVVVEIQNFETFQQHFPVNNETFVKAKIDYKDVAEEIREAE
Newman RAYGGHVLDFEVDDVVVEIQNFETFQQHFPVNNETFVKAKIDYNDVAEEIREAE
USA300_FPR3757 RAYGGHVLDFEVDDVVVEIQNFETFQQHFPVNNETFVKAKIDYKDVAEEIREAE
*******************************************:**********
- ↑ Xian Zhang, Zhiming Rao, Jingjing Li, Junping Zhou, Taowei Yang, Meijuan Xu, Teng Bao, Xiaojing Zhao
Improving the acidic stability of Staphylococcus aureus α-acetolactate decarboxylase in Bacillus subtilis by changing basic residues to acidic residues.
Amino Acids: 2015, 47(4);707-17
[PubMed:25543264] [WorldCat.org] [DOI] (I p)