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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005949000
- symbol?: mdeA
- synonym:
- description?: drug:proton antiporter
- drug:proton antiporter
- multidrug efflux MFS transporter MdeA
- drug resistance transporter EmrB/QacA subfamily protein
- EmrB/QacA family drug resistance transporter
- EmrB-QacA subfamily drug resistance transporter, putative
- MFS transporter
- multidrug resistance protein
- drug resistance MFS transporter, drug:H+ antiporter-1 (14 Spanner) (DHA2) family protein
- H+ antiporter-2 family protein
- lincomycin resistance protein LmrB
- major facilitator superfamily multidrug :cation symporter
- MFS family major facilitator transporter, multidrug :cation symporter
- multidrug resistance protein B
- multidrug resistance protein YcnB
- multidrug resistanc-related transport system protein
- putative transport system protein
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 6012572..6013930
- synteny block?: BlockID0046930
- occurrence?: in 100% of 34 strains
mdeA : multidrug resistance MFS efflux transporter A [1]
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2352
08BA02176:
C248_2460
11819-97:
MS7_2430
6850:
RSAU_002253
71193:
ST398NM01_2466
ECT-R 2:
ECTR2_2274
ED133:
SAOV_2461c
ED98:
SAAV_2480
HO 5096 0412:
SAEMRSA15_23140
JH1:
SaurJH1_2488
JH9:
SaurJH9_2440
JKD6008:
SAA6008_02456
JKD6159:
SAA6159_02316
JSNZ:
JSNZ_002386 (mdeA)
LGA251:
SARLGA251_21970
M013:
M013TW_2376
MRSA252:
SAR2505
MSHR1132:
SAMSHR1132_22430
MSSA476:
SAS2306
Mu3:
SAHV_2399
Mu50:
SAV2415
MW2:
MW2337
RF122:
SAB2295c
ST398:
SAPIG2466
T0131:
SAT0131_02606 (fmt)
TCH60:
HMPREF0772_10772 (lmrB2)
TW20:
SATW20_25450
USA300_TCH1516:
USA300HOU_2396
VC40:
SAVC_10945
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL --------------MGGFFGLLNETLLVTALPSIMKDFEISYTQVQWLTTAFLLTNGIVI
N315 MSKKQKLTMIITMLMGGFFGLLNETLLVTALPSIMKDFEISYTQVQWLTTAFLLTNGIVI
NCTC8325 ---------------------------MTALPSIMKDFEISYTQVQWLTTAFLLTNGIVI
Newman ---------------------------MTAYPSIMKDFEISYTQVQWLTTAFLLTNGIVI
USA300_FPR3757 ---------------------------MTALPSIMKDFEISYTQVQWLTTAFLLTNGIVI
:** *****************************
COL PLSALVIQRYTTRQVFLVGISIFFLGTLLGGLSPHFATLLVARIIQALGAGIMMPLMMTT
N315 PLSALVIQRYTTRQVFLVGISIFFLGTLLGGLSPHFATLLVARIIQALGAGIMMPLMMTT
NCTC8325 PLSALVIQRYTTRQVFLVGISIFFLGTLLGGLSPHFATLLVARIIQALGAGIMMPLMMTT
Newman PLSALVIQRYTTRQVFLVGISIFFLGTLLGGLSPHFATLLVARIIQALGAGIMMPLMMTT
USA300_FPR3757 PLSALVIQRYTTRQVFLVGISIFFLGTLLGGLSPHFATLLVARIIQALGAGIMMPLMMTT
************************************************************
COL ILDVFQPHERGKYMGIFGLVIGLAPAIGPTLSGYLVEYFNWRSLFHVVAPIAAVTFLIGF
N315 ILDVFQPHERGKYMGIFGLVIGLAPAIGPTLSGYLVEYLNWRSLFHVVAPIAAVTFLIGF
NCTC8325 ILDVFQPHERGKYMGIFGLVIGLAPAIGPTLSGYLVEYFNWRSLFHVVAPIAAVTFLIGF
Newman ILDVFQPHERGKYMGIFGLVIGLAPAIGPTLSGYLVEYFNWRSLFHVVAPIAAVTFLIGF
USA300_FPR3757 ILDVFQPHERGKYMGIFGLVIGLAPAIGPTLSGYLVEYFNWRSLFHVVAPIAAVTFLIGF
**************************************:*********************
COL KTIKNVGTTIKVPIDFISVIFSVLGFGGLLYGTSSISEKGFDNPIVLVSMIGGVVLVALF
N315 KTIKNVGTTIKVPIDFISVIFSVLGFGGLLYGTSSISEKGFDNPIVLVSMIGGVVLVALF
NCTC8325 KTIKNVGTTIKVPIDFISVIFSVLGFGGLLYGTSSISEKGFDNPIVLVSMIGGVVLVALF
Newman KTIKNVGTTIKVPIDFISVIFSVLGFGGLLYGTSSISEKGFDNPIVLVSMIGGVVLVALF
USA300_FPR3757 KTIKNVGTTIKVPIDFISVIFSVLGFGGLLYGTSSISEKGFDNPIVLVSMIGGVVLVALF
************************************************************
COL VLRQYRLSTPLLNFAVFKNKQFTVGIIIMGVTMVSMIGSETILPIFVQNLLHRSALDSGL
N315 VLRQYRLSTPLLNFAVFKNKQFTVGIIIMGVTMVSMIGSETILPIFVQNLLHRSALDSGL
NCTC8325 VLRQYRLSTPLLNFAVFKNKQFTVGIIIMGVTMVSMIGSETILPIFVQNLLHRSALDSGL
Newman VLRQYRLSTPLLNFAVFKNKQFTVGIIIMGVTMVSMIGSETILPIFVQNLLHRSALDSGL
USA300_FPR3757 VLRQYRLSTPLLNFAVFKNKQFTVGIIIMGVTMVSMIGSETILPIFVQNLLHRSALDSGL
************************************************************
COL TLLPGAIVMAFMSMTSGALYEKFGPRNLALVGMAIVVITTAYFVVMDEQTSTIMLATVYA
N315 TLLPGAIVMAFMSMTSGALYEKFGPRKLALVGMAIVVITTAYFVVMDEQTSTIMLATVYA
NCTC8325 TLLPGAIVMAFMSMTSGALYEKFGPRNLALVGMAIVVITTAYFVVMDEQTSTIMLATVYA
Newman TLLPGAIVMAFMSMTSGALYEKFGPRNLALVGMAIVVITTAYFVVMDEQTSTIMLATVYA
USA300_FPR3757 TLLPGAIVMAFMSMTSGALYEKFGPRNLALVGMAIVVITTAYFVVMDEQTSTIMLATVYA
**************************:*********************************
COL IRMVGIALGLIPVMTHTMNQLKPEMNAHGSSMTNTVQQIAGSIGTAALITILSHASKNFS
N315 IRMVGIALGLIPVMTHTMNQLKPEMNAHGSSMTNTVQQIAGSIGTAALITILSHASKNFS
NCTC8325 IRMVGIALGLIPVMTHTMNQLKPEMNAHGSSMTNTVQQIAGSIGTAALITILSHASKNFS
Newman IRMVGIALGLIPVMTHTMNQLKPEMNAHGSSMTNTVQQIAGSIGTAALITILSHASKNFS
USA300_FPR3757 IRMVGIALGLIPVMTHTMNQLKPEMNAHGSSMTNTVQQIAGSIGTAALITILSHASKNFS
************************************************************
COL PTMSDYNGMNKIDMMNQIKVDTMLHGYHAGFLFALLITVVSFFCSFMLQGKKKEVDSRQ
N315 PTMSDYNGMNKIDMMNQIKVDTMLHGYHAGFLFALLITVVSFFCSFMLQGKKKEVDSRQ
NCTC8325 PTMSDYNGMNKIDMMNQIKVDTMLHGYHAGFLFALLITVVSFFCSFMLQGKKKEVDSRQ
Newman PTMSDYNGMNKIDMMNQIKVDTMLHGYHAGFLFALLITVVSFFCSFMLQGKKKEVDSRQ
USA300_FPR3757 PTMSDYNGMNKIDMMNQIKVDTMLHGYHAGFLFALLITVVSFFCSFMLQGKKKEVDSRQ
***********************************************************
- ↑ Jianzhong Huang, Paul W O'Toole, Wei Shen, Heather Amrine-Madsen, Xinhe Jiang, Neethan Lobo, Leslie M Palmer, LeRoy Voelker, Frank Fan, Michael N Gwynn, Damien McDevitt
Novel chromosomally encoded multidrug efflux transporter MdeA in Staphylococcus aureus.
Antimicrob Agents Chemother: 2004, 48(3);909-17
[PubMed:14982783] [WorldCat.org] [DOI] (P p)Youichi Yamada, Sumiko Shiota, Tohru Mizushima, Teruo Kuroda, Tomofusa Tsuchiya
Functional gene cloning and characterization of MdeA, a multidrug efflux pump from Staphylococcus aureus.
Biol Pharm Bull: 2006, 29(4);801-4
[PubMed:16595922] [WorldCat.org] [DOI] (P p)Mary K Phillips-Jones, Stephen E Harding
Antimicrobial resistance (AMR) nanomachines-mechanisms for fluoroquinolone and glycopeptide recognition, efflux and/or deactivation.
Biophys Rev: 2018, 10(2);347-362
[PubMed:29525835] [WorldCat.org] [DOI] (P p)