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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005786000
- symbol?: fdhA
- synonym:
- description?: formate dehydrogenase subunit alpha
- formate dehydrogenase subunit alpha
- formate dehydrogenase, alpha subunit
- formate dehydrogenase, alpha subunit, putative
- formate dehydrogenase-like protein
- bifunctional protein GlmU
- formate dehydrogenase alpha subunit
- Formate dehydrogenase related protein
- molybdopterin oxidoreductase
- molybdopterin oxidoreductase family protein
- NAD-dependent formate dehydrogenase
- putative bifunctional protein
- Putative formate dehydrogenase
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 5870849..5873803
- synteny block?: BlockID0045310
- occurrence?: in 100% of 34 strains
forC (yrhE, forC2, fdhA) : formate oxidoreductase catalytic subunit [1]
Firmicutes are able to oxidize formate to carbon dioxide and reduce CO2 to bioavailable formate using an atypical molybdopterin-, iron-sulfur cluster- and menaquinone- dependent enzyme. These enzymes are characterized by a catalytic subunit which binds the formyl substrate and an essential subunit that shuttles electrons to or from the menaquinone cofactor. Bacillus encodes two pairs of these recently-discovered enzymes named forCE and forCE2. Staphylococci only contain one version and, unfortunately, they are orthologues of forCE2. Therefore staphylococcal forC and forE are orthologues of Bacillus forC2 and forE2 genes.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2248
08BA02176:
C248_2351 (fdhG)
11819-97:
MS7_2326
6850:
RSAU_002146 (mopB)
71193:
ST398NM01_2360
ECT-R 2:
ECTR2_2168 (fdhA)
ED133:
SAOV_2349c
ED98:
SAAV_2371
HO 5096 0412:
SAEMRSA15_22070
JH1:
SaurJH1_2376
JH9:
SaurJH9_2333
JKD6008:
SAA6008_02344
JKD6159:
SAA6159_02213
JSNZ:
JSNZ_002276 (fdhF)
LGA251:
SARLGA251_20920
M013:
M013TW_2266
MRSA252:
SAR2393
MSHR1132:
SAMSHR1132_21340
MSSA476:
SAS2201
Mu3:
SAHV_2293
Mu50:
SAV2309
MW2:
MW2229
RF122:
SAB2186c
ST398:
SAPIG2360
T0131:
SAT0131_02488 (sdhC)
TCH60:
HMPREF0772_10886 (fdhA)
TW20:
SATW20_24400
USA300_TCH1516:
USA300HOU_2291
VC40:
SAVC_10405
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MQEHLVVTLDGKDYLVEPGTNLLEFIKSQDTFVPSICYNESMGPIQTCDTCTVEIDGKIE
N315 MQEHLVVTLDGKDYLVEPGTNLLEFIKSQDTFVPSICYNESMGPIQTCDTCTVEIDGKIE
NCTC8325 MQEHLVVTLDGKDYLVEPGTNLLEFIKSQDTFVPSICYNESMGPIQTCDTCTVEIDGKIE
Newman MQEHLVVTLDGKDYLVEPGTNLLEFIKSQDTFVPSICYNESMGPIQTCDTCTVEIDGKIE
USA300_FPR3757 MQEHLVVTLDGKDYLVEPGTNLLEFIKSQDTFVPSICYNESMGPIQTCDTCTVEIDGKIE
************************************************************
COL RSCSTVIDRPMTVNTVNNDVKDAQKEALDRILEKHMLYCTVCDYNNGDCEIHNTMDAWGL
N315 RSCSTVIDRPMTVNTVNNDVKDAQKEALDRILEKHMLYCTVCDYNNGDCEIHNTMDAWGL
NCTC8325 RSCSTVIDRPMTVNTVNNDVKDAQKEALDRILEKHMLYCTVCDYNNGDCEIHNTMDAWGL
Newman RSCSTVIDRPMTVNTVNNDVKDAQKEALDRILEKHMLYCTVCDYNNGDCEIHNTMDAWGL
USA300_FPR3757 RSCSTVIDRPMTVNTVNNDVKDAQKEALDRILEKHMLYCTVCDYNNGDCEIHNTMDAWGL
************************************************************
COL QHQTYEYKEKPYEKDYGPFYRYDPNQCILCGRCVEACQDIEVNETIRIDWDREHPRVIWD
N315 QHQTYEYKEKPYEKDYGPFYRYDPNQCILCGRCVEACQDIEVNETIRIDWDREHPRVIWD
NCTC8325 QHQTYEYKEKPYEKDYGPFYRYDPNQCILCGRCVEACQDIEVNETIRIDWDREHPRVIWD
Newman QHQTYEYKEKPYEKDYGPFYRYDPNQCILCGRCVEACQDIEVNETIRIDWDREHPRVIWD
USA300_FPR3757 QHQTYEYKEKPYEKDYGPFYRYDPNQCILCGRCVEACQDIEVNETIRIDWDREHPRVIWD
************************************************************
COL NDVPINESSCVSCGQCATVCPCNAMMEVNMEGNAGYMTDTEPGSLAAMIDLTKKAEPGYG
N315 NDVPINESSCVSCGQCATVCPCNAMMEVNMEGNAGYMTDTEPGSLAAMIDLTKKAEPGYG
NCTC8325 NDVPINESSCVSCGQCATVCPCNAMMEVNMEGNAGYMTDTEPGSLAAMIDLTKKAEPGYG
Newman NDVPINESSCVSCGQCATVCPCNAMMEVNMEGNAGYMTDTEPGSLAAMIDLTKKAEPGYG
USA300_FPR3757 NDVPINESSCVSCGQCATVCPCNAMMEVNMEGNAGYMTDTEPGSLAAMIDLTKKAEPGYG
************************************************************
COL PLFAISDSEAEMRKERIKKTKTVCTYCGVGCSFEVWTKDREILKVQPSHDSPANKIATCV
N315 PLFAISDSEAEMRKERIKKTKTVCTYCGVGCSFEVWTKDREILKVQPSHDSPANKIATCV
NCTC8325 PLFAISDSEAEMRKERIKKTKTVCTYCGVGCSFEVWTKDREILKVQPSHDSPANKIATCV
Newman PLFAISDSEAEMRKERIKKTKTVCTYCGVGCSFEVWTKDREILKVQPSHDSPANKIATCV
USA300_FPR3757 PLFAISDSEAEMRKERIKKTKTVCTYCGVGCSFEVWTKDREILKVQPSHDSPANKIATCV
************************************************************
COL KGKFSWGHINSDQRLTKPLVRKNGEFHEVEWDEALNVIADNFTAIKEKHGPDALSFISSS
N315 KGKFSWGHINSDQRLTKPLVRKNGEFHEVEWDEALNVIADNFTSIKEKYGPDALSFISSS
NCTC8325 KGKFSWGHINSDQRLTKPLVRKNGEFHEVEWDEALNVIADNFTAIKEKHGPDALSFISSS
Newman KGKFSWGHINSDQRLTKPLVRKNGEFHEVEWDEALNVIADNFTAIKEKHGPDALSFISSS
USA300_FPR3757 KGKFSWGHINSDQRLTKPLVRKNGEFHEVEWDEALNVIADNFTAIKEKHGPDALSFISSS
*******************************************:****:***********
COL KATNEESYLMQKLARQVIGTNNVDNCSRYCQAPATKGLFRTVGHGGDSGSIEDLEKAAMS
N315 KATNEESYLMQKLARQVIGTNNVDNCSRYCQAPATKGLFRTVGHGGDSGSIEDLEKAAMS
NCTC8325 KATNEESYLMQKLARQVIGTNNVDNCSRYCQAPATKGLFRTVGHGGDSGSIEDLEKAAMS
Newman KATNEESYLMQKLARQVIGTNNVDNCSRYCQAPATKGLFRTVGHGGDSGSIEDLEKAAMS
USA300_FPR3757 KATNEESYLMQKLARQVIGTNNVDNCSRYCQAPATKGLFRTVGHGGDSGSIEDLEKAAMS
************************************************************
COL VLIGTNTAEAHPVIASRMKRAQKLFGQKIHVFDIRKHEMAERADRFYQPKPGTDLAWLSA
N315 VLIGTNTAEAHPVIASRMKRAQKLFGQKIHVFDIRKHEMAERADRFYQPKPGTDLAWLSA
NCTC8325 VLIGTNTAEAHPVIASRMKRAQKLFGQKIHVFDIRKHEMAERADRFYQPKPGTDLAWLSA
Newman VLIGTNTAEAHPVIASRMKRAQKLFGQKIHVFDIRKHEMAERADRFYQPKPGTDLAWLSA
USA300_FPR3757 VLIGTNTAEAHPVIASRMKRAQKLFGQKIHVFDIRKHEMAERADRFYQPKPGTDLAWLSA
************************************************************
COL VTKYIIDHDLHDKAFIDEWVDDFDEYYKSLETFTMAFAEEATGIPESELIKFAEECAKAE
N315 VTKYIIDHDLHDKAFIDEWVDDFDEYYKSLETFTMAFAEEATGIPESELIKFAEECAKAE
NCTC8325 VTKYIIDHDLHDKAFIDEWVDDFDEYYKSLETFTMAFAEEATGIPESELIKFAEECAKAE
Newman VTKYIIDHDLHDKAFIDEWVDDFDEYYKSLETFTMAFAEEATGIPESELIKFAEECAKAE
USA300_FPR3757 VTKYIIDHDLHDKAFIDEWVDDFDEYYKSLETFTMAFAEEATGIPESELIKFAEECAKAE
************************************************************
COL SVVICWAMGITQQDIGSDSSTAISNLLLVTGNYRRPGTGAYPLRGHNNVQGCSDMGSMPD
N315 SVVICWAMGITQQDIGSDSSTAISNLLLVTGNYRRPGTGAYPLRGHNNVQGCSDMGSMPD
NCTC8325 SVVICWAMGITQQDIGSDSSTAISNLLLVTGNYRRPGTGAYPLRGHNNVQGCSDMGSMPD
Newman SVVICWAMGITQQDIGSDSSTAISNLLLVTGNYRRPGTGAYPLRGHNNVQGCSDMGSMPD
USA300_FPR3757 SVVICWAMGITQQDIGSDSSTAISNLLLVTGNYRRPGTGAYPLRGHNNVQGCSDMGSMPD
************************************************************
COL KITGYQSIEADDIRAKFEKEYGVKLNPKAGKDNHEMVEGIHDGEVHSLYLYGEDTGIVDS
N315 KITGYQSIEADDIRAKFEKEYGVKLNPKAGKDNHEMVEGIHDGEVHSLYLYGEDTGIVDS
NCTC8325 KITGYQSIEADDIRAKFEKEYGVKLNPKAGKDNHEMVEGIHDGEVHSLYLYGEDTGIVDS
Newman KITGYQSIEADDIRAKFEKEYGVKLNPKAGKDNHEMVEGIHDGEVHSLYLYGEDTGIVDS
USA300_FPR3757 KITGYQSIEADDIRAKFEKEYGVKLNPKAGKDNHEMVEGIHDGEVHSLYLYGEDTGIVDS
************************************************************
COL NINFVQAAFEKLDFMVVQDEFLTFTATYADVVLPASPSLEKDGTFTNTERRIQRLYQALE
N315 NINFVQAAFEKLDFMVVQDEFLTFTATYADVVLPASPSLEKDGTFTNTERRIQRLYQALE
NCTC8325 NINFVQAAFEKLDFMVVQDEFLTFTATYADVVLPASPSLEKDGTFTNTERRIQRLYQALE
Newman NINFVQAAFEKLDFMVVQDEFLTFTATYADVVLPASPSLEKDGTFTNTERRIQRLYQALE
USA300_FPR3757 NINFVQAAFEKLDFMVVQDEFLTFTATYADVVLPASPSLEKDGTFTNTERRIQRLYQALE
************************************************************
COL PLGDSKPDWKIFQAIANRLGFDWNYKHPSEIMDEVARLTPLYAGVSYDRLEGFNSLQWPV
N315 PLGDSKPDWKIFQAIANRLGFDWNYKHPSEIMDEVARLTPLYAGVSYDRLEGFNSLQWPV
NCTC8325 PLGDSKPDWKIFQAIANRLGFDWNYKHPSEIMDEVARLTPLYAGVSYDRLEGFNSLQWPV
Newman PLGDSKPDWKIFQAIANRLGFDWNYKHPSEIMDEVARLTPLYAGVSYDRLEGFNSLQWPV
USA300_FPR3757 PLGDSKPDWKIFQAIANRLGFDWNYKHPSEIMDEVARLTPLYAGVSYDRLEGFNSLQWPV
************************************************************
COL QPDGTDEPILYLEGFNFDNGKAKLFPLSFDNYFKQDEIYDIHVNNGRLLEHFHEGNMTYQ
N315 QPDGTDEPILYLEGFNFDNGKAKLFPLSFDNYFKQDEIYDIHVNNGRLLEHFHEGNMTYQ
NCTC8325 QPDGTDEPILYLEGFNFDNGKAKLFPLSFDNYFKQDEIYDIHVNNGRLLEHFHEGNMTYQ
Newman QPDGTDEPILYLEGFNFDNGKAKLFPLSFDNYFKQDEIYDIHVNNGRLLEHFHEGNMTYQ
USA300_FPR3757 QPDGTDEPILYLEGFNFDNGKAKLFPLSFDNYFKQDEIYDIHVNNGRLLEHFHEGNMTYQ
************************************************************
COL TPMIKYKVPRAFVEISPELAEDRGIHEGAEVKLISETGEAVLQVHVTDRVKGKEIYIPLN
N315 TPMIKYKVPRAFVEISPELAEDRGIHEGAEVKLISETGEAVLQVHVTDRVKGKEIYIPLN
NCTC8325 TPMIKYKVPRAFVEISPELAEDRGIHEGAEVKLISETGEAVLQVHVTDRVKGKEIYIPLN
Newman TPMIKYKVPRAFVEISPELAEDRGIHEGAEVKLISETGEAVLQVHVTDRVKGKEIYIPLN
USA300_FPR3757 TPMIKYKVPRAFVEISPELAEDRGIHEGAEVKLISETGEAVLQVHVTDRVKGKEIYIPLN
************************************************************
COL NDAMENGDLGAINLLTNSDVDQYTDTPSYKRTSCRLEVITKRGKSPLNPNNFRVNKKRQP
N315 NDAMENGDLGAINLLTNSDVDQYTDTPSYKRTSCRLEVITKRGKSPLNPNNFRVNKKRHP
NCTC8325 NDAMENGDLGAINLLTNSDVDQYTDTPSYKRTSCRLEVITKRGKSPLNPNNFRVNKKRQP
Newman NDAMENGDLGAINLLTNSDVDQYTDTPSYKRTSCRLEVITKRGKSPLNPNNFRVNKKRQP
USA300_FPR3757 NDAMENGDLGAINLLTNSDVDQYTDTPSYKRTSCRLEVITKRGKSPLNPNNFRVNKKRQP
**********************************************************:*
COL QYSVQVQKKWERSDYVFPGNQVDK
N315 QYSVQVQKKWERSDYVFPGNQVDK
NCTC8325 QYSVQVQKKWERSDYVFPGNQVDK
Newman QYSVQVQKKWERSDYVFPGNQVDK
USA300_FPR3757 QYSVQVQKKWERSDYVFPGNQVDK
************************
- ↑ Rodrigo Arias-Cartín, Alexandre Uzel, Farida Seduk, Guillaume Gerbaud, Fabien Pierrel, Marianne Broc, Régine Lebrun, Bruno Guigliarelli, Axel Magalon, Stéphane Grimaldi, Anne Walburger
Identification and characterization of a noncanonical menaquinone-linked formate dehydrogenase.
J Biol Chem: 2022, 298(2);101384
[PubMed:34748728] [WorldCat.org] [DOI] (I p)