Jump to navigation
Jump to search
⊟Summary[edit | edit source]
- pan ID?: SAUPAN005624000
- symbol?: budA1
- synonym:
- description?: alpha-acetolactate decarboxylase
- alpha-acetolactate decarboxylase
- acetolactate decarboxylase
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 5760475..5761179
- synteny block?: BlockID0043770
- occurrence?: in 100% of 34 strains
alsD1 (aldC1, budA1) : programmed cell acidification antagonist acetolactate decarboxylase [1]
• Staphylococcus aureus encodes two acetolactate decarboxylases. This version, AlsD1, is inducible as part of the CidR regulon and counteracts programmed cell acidification by directing pyruvate carbon flux toward acetoin rather than toward acetic acid via CidC. While the typical nomenclature for this version is "alsD" and the branched chain amino acid biosynthesis paralogue is "budA", we are appending the "1" numeral here for additional clarity due to inconsistent nomenclature use in existing sequenced genomes.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2143
08BA02176:
C248_2249
11819-97:
MS7_2234
6850:
RSAU_002049 (budA)
71193:
ST398NM01_2267
ECT-R 2:
ECTR2_2067 (budA)
ED133:
SAOV_2251c
ED98:
SAAV_2267 (budA1)
HO 5096 0412:
SAEMRSA15_21130
JH1:
SaurJH1_2275
JH9:
SaurJH9_2236
JKD6008:
SAA6008_02247 (budA1)
JKD6159:
SAA6159_02118 (budA1)
JSNZ:
JSNZ_002177 (budA)
LGA251:
SARLGA251_20000
M013:
M013TW_2173
MRSA252:
SAR2296
MSHR1132:
SAMSHR1132_20370
MSSA476:
SAS2105
Mu3:
SAHV_2190
Mu50:
SAV2206
MW2:
MW2131
RF122:
SAB2086c
ST398:
SAPIG2267 (budA)
T0131:
SAT0131_02382
TCH60:
HMPREF0772_10985 (budA2)
TW20:
SATW20_23440
USA300_TCH1516:
USA300HOU_2201 (alsD)
VC40:
SAVC_09920
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL ----MTNVLYQHGTLGTLMAGLLKGTASINELLQHGDLGIATLTGSNGEVIFLDGKAYHA
N315 ----MTNVLYQHGTLGTLMAGLLKGTASINELLQHGDLGIATLTGSNGEVIFLDGKAYHA
NCTC8325 ----MTNVLYQHGTLGTLMAGLLKGTASINELLQHGDLGIATLTGSNGEVIFLDGKAYHA
Newman MGDFMTNVLYQHGTLGTLMAGLLKGTASINELLQHGDLGIATLTGSNGEVIFLDGKAYHA
USA300_FPR3757 ----MTNVLYQHGTLGTLMAGLLKGTASINELLQHGDLGIATLTGSNGEVIFLDGKAYHA
********************************************************
COL NEHKEFVELKGDELTPYATVTKFVADTSYETKDKSSEAVFAEIKEKMLSENLFSAVKISG
N315 NEHKEFVELKGDELTPYATVTKFVADTSYETKDKSSEAVFAEIKEKMLSENLFSAVKISG
NCTC8325 NEHKEFVELKGDELTPYATVTKFVADTSYETKDKSSEAVFAEIKEKMLSENLFSAVKISG
Newman NEHKEFVELKGDELTPYATVTKFVADTSYETKDKSSEAVFAEIKEKMLSENLFSAVKISG
USA300_FPR3757 NEHKEFVELKGDELTPYATVTKFVADTSYETKDKSSEAVFAEIKEKMLSENLFSAVKISG
************************************************************
COL LFKKMHVRMMPAQEPPYTRLIDSARRQPEQTETYVKGSVVGFFTPELFHGIGSAGFHVHF
N315 LFKKMHVRMMPAQEPPYTRLIDSARRQPEQTETYVKGSVVGFFTPELFHGIGSAGFHVHF
NCTC8325 LFKKMHVRMMPAQEPPYTRLIDSARRQPEQTETYVKGSVVGFFTPELFHGIGSAGFHVHF
Newman LFKKMHVRMMPAQEPPYTRLIDSARRQPEQTETYVKGSVVGFFTPELFHGIGSAGFHVHF
USA300_FPR3757 LFKKMHVRMMPAQEPPYTRLIDSARRQPEQTETYVKGSVVGFFTPELFHGIGSAGFHVHF
************************************************************
COL ANDDRNFGGHVLDFEVEDVKVEIQNIETFEQHFPIQDKDFTKANIDYKDIADEIREAE
N315 ANDDRNFGGHVLDFEVEDVKVEIQNIETFEQHFPIQDKDFTKANIDYKDIADEIREAE
NCTC8325 ANDDRNFGGHVLDFEVEDVKVEIQNIETFEQHFPIQDKDFTKANIDYKDIADEIREAE
Newman ANDDRNFGGHVLDFEVEDVKVEIQNIETFEQHFPIQDKDFTKANIDYKDIADEIREAE
USA300_FPR3757 ANDDRNFGGHVLDFEVEDVKVEIQNIETFEQHFPIQDKDFTKANIDYKDIADEIREAE
**********************************************************
- ↑ Soo-Jin Yang, Paul M Dunman, Steven J Projan, Kenneth W Bayles
Characterization of the Staphylococcus aureus CidR regulon: elucidation of a novel role for acetoin metabolism in cell death and lysis.
Mol Microbiol: 2006, 60(2);458-68
[PubMed:16573694] [WorldCat.org] [DOI] (P p)Sujata S Chaudhari, Vinai C Thomas, Marat R Sadykov, Jeffrey L Bose, Daniel J Ahn, Matthew C Zimmerman, Kenneth W Bayles
The LysR-type transcriptional regulator, CidR, regulates stationary phase cell death in Staphylococcus aureus.
Mol Microbiol: 2016, 101(6);942-53
[PubMed:27253847] [WorldCat.org] [DOI] (I p)