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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005020000
- symbol?: chp
- synonym:
- description?: chemotaxis-inhibiting protein CHIPS
- chemotaxis-inhibiting protein CHIPS
- chemotaxis inhibitory protein
- Chemotaxis-inhibiting protein CHIPS, phage associated
- chemotaxis inhibitory protein (CHIPS)
- chemotaxis inhibitory protein CHIPS
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 5194509..5194958
- synteny block?: BlockID0039010
- occurrence?: in 44% of 34 strains
chp : prophage-encoded chemotaxis-inhibiting protein CHIPS [1]
• A crystal structure is available : 1XEE
Chemotaxis-inhibiting protein CHIPS is a component of the immune evasion module found on hlb-converting prophage that is a major contributor to human pathogenic potential. CHIPS specifically neutralizes C5a and formylated peptide receptors (FPRs) on monocytes and neutrophils. By blocking these receptors, CHIPs prevents chemotaxis and initiation of pro-inflammatory cascades.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1902
08BA02176:
—
11819-97:
—
6850:
RSAU_000619
71193:
ST398NM01_2913
ECT-R 2:
ECTR2_1815
ED133:
—
ED98:
—
HO 5096 0412:
SAEMRSA15_18590 (chp)
JH1:
SaurJH1_2035
JH9:
SaurJH9_2000
JKD6008:
—
JKD6159:
SAA6159_01873 (chs)
JSNZ:
—
LGA251:
—
M013:
—
MRSA252:
SAR2036 (chp)
MSHR1132:
—
MSSA476:
—
Mu3:
—
Mu50:
—
MW2:
—
RF122:
—
ST398:
—
T0131:
—
TCH60:
HMPREF0772_11197 (chp)
TW20:
—
USA300_TCH1516:
USA300HOU_1947 (chp)
VC40:
—
⊟Genome Viewer[edit | edit source]
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
N315 MKKKLATTVLALSFLTAGISTHHHSAKAFTFEPFPTNEEIESNKKMLEKEKAYKESFKNS
NCTC8325 MKKKLATTVLALSFLTAGISTHHHSAKAFTFEPFPTNEEIESNKKLLEKEKAYKESFKNS
Newman MKKKLATTVLALSFLTAGISTHHHSAKAFTFEPFPTNEEIESNKKMLEKEKAYKESFKNS
USA300_FPR3757 MKKKLATTVLALSFLTAGISTHHHSAKAFTFEPFPTNEEIESNKKMLEKEKAYKESFKNS
*********************************************:**************
N315 GLPTTLGKLDERLRNYLEKGTKNTAQFEKMVILTENKGYYTVYLNTPLAEDRKNVELLGK
NCTC8325 GLPTTLGKLDERLRNYLKKGTKNSAQFEKMVILTENKGYYTVYLNTPLAEDRKNVELLGK
Newman GLPTTLGKLDERLRNYLKKGTKNSAQFEKMVILTENKGYYTVYLNTPLAEDRKNVELLGK
USA300_FPR3757 GLPTTLGKLDERLRNYLKKGTKNSAQFEKMVILTENKGYYTVYLNTPLAEDRKNVELLGK
*****************:*****:************************************
N315 MYKTYFFKKGESKSSYVINGPGKTNEYAY
NCTC8325 MYKTYFFKKGESKSSYVINGPGKTNEYAY
Newman MYKTYFFKKGESKSSYVINGPGKTNEYAY
USA300_FPR3757 MYKTYFFKKGESKSSYVINGPGKTNEYAY
*****************************
- ↑ Anton Bunschoten, Louris J Feitsma, John A W Kruijtzer, Carla J C de Haas, Rob M J Liskamp, Johan Kemmink
CHIPS binds to the phosphorylated N-terminus of the C5a-receptor.
Bioorg Med Chem Lett: 2010, 20(11);3338-40
[PubMed:20457523] [WorldCat.org] [DOI] (I p)Youssif M Ali, Abeer M Abd El-Aziz, Maha Mabrook, Ahmed A Shabaan, Robert B Sim, Ramadan Hassan
Recombinant chemotaxis inhibitory protein of Staphylococcus aureus (CHIPS) protects against LPS-induced lung injury in mice.
Clin Immunol: 2018, 197;27-33
[PubMed:30145330] [WorldCat.org] [DOI] (I p)