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⊟Summary[edit | edit source]
- pan ID?: SAUPAN004792000
- symbol?: queG
- synonym:
- description?: epoxyqueuosine reductase
- epoxyqueuosine reductase
- tRNA epoxyqueuosine(34) reductase QueG
- iron-sulfur cluster-binding protein
- iron-sulfur cluster-binding protein, putative
- putative iron-sulfur cluster-binding protein
- iron-sulfur (Fe-S) cluster-binding protein
- iron-sulfur binding protein
- (Fe-S)-binding protein
- phenylalanyl-tRNA synthetase subunit alpha
- putative iron-sulfur protein
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 4999079..5000209
- synteny block?: BlockID0037240
- occurrence?: in 100% of 34 strains
queG : epoxyqueuosine reductase [1]
Several transfer RNAs require modifications to provide maximal fidelity during protein synthesis. QueG catalyzes the final modification on tRNA epoxyqueuosine(34) residues, reducing the epoxide to a carbon-carbon double bond and generating the final queuosine(34) nucleobase product. Staphylococcal tRNAs requiring this modification include: tRNAHGUG, tRNAYGUA, tRNANGUU, tRNADGUC.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1812
08BA02176:
C248_1900
11819-97:
MS7_1861
6850:
RSAU_001715
71193:
ST398NM01_1922
ECT-R 2:
ECTR2_1698
ED133:
SAOV_1853
ED98:
SAAV_1875
HO 5096 0412:
SAEMRSA15_17610
JH1:
SaurJH1_1944
JH9:
SaurJH9_1910
JKD6008:
SAA6008_01813
JKD6159:
SAA6159_01785
LGA251:
SARLGA251_17390
M013:
M013TW_1862
MRSA252:
SAR1947
MSHR1132:
SAMSHR1132_17020
MSSA476:
SAS1779
Mu3:
SAHV_1841
Mu50:
SAV1856
MW2:
MW1797
RF122:
SAB1790c
ST398:
SAPIG1922
T0131:
SAT0131_01976
TCH60:
HMPREF0772_11288
TW20:
SATW20_18500
USA300_TCH1516:
USA300HOU_1851
VC40:
SAVC_08530
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 | |
| JSNZ |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL -----MDTKQLKQDIIDYAYTIGIDSIGFTTADPFDELKQKLEAYHANGYASGFEESDIA
N315 -----MDTKQLKQDIIDYAYTIGIDSIGFTTADPFDELKQKLEAYHANGYASGFEESDIA
NCTC8325 MGGIRLDTKQLKQDIIDYAYTIGIDSIGFTTADPFDELKQKLEAYHANGYASGFEESDIA
Newman -----MDTKQLKQDIIDYAYTIGIDSIGFTTADPFDELKQKLEAYHANGYASGFEESDIA
USA300_FPR3757 -----MDTKQLKQDIIDYAYTIGIDSIGFTTADPFDELKQKLEAYHANGYASGFEESDIA
:******************************************************
COL LRTEPKLSLPTARSIIAIAVGYPNKLKGAPKSVRGDRRGLFARASWGQDYHTIMRKRLDM
N315 LRTEPKLSLPTARSIIAIAVGYPNKLKGAPKSVRGDRRGLFARASWGQDYHTIMRKRLDM
NCTC8325 LRTEPKLSLPTARSIIAIAVGYPNKLKGAPKSVRGDRRGLFARASWGQDYHTIMRKRLDM
Newman LRTEPKLSLPTARSIIAIAVGYPNKLKGAPKSVRGDRRGLFARASWGQDYHTIMRKRLDM
USA300_FPR3757 LRTEPKLSLPTARSIIAIAVGYPNKLKGAPKSVRGDRRGLFARASWGQDYHTIMRKRLDM
************************************************************
COL LAAFIESKVPDVEIKSMVDTGVLSDRAVAERAGLGFVGRNGFVINPKLGTWTYLGEMLVS
N315 LAAFIESKVPDVEIKSMVDTGVLSDRAVAERAGLGFVGRNGFVINPKLGTWTYLGEMLVS
NCTC8325 LAAFIESKVPDVEIKSMVDTGVLSDRAVAERAGLGFVGRNGFVINPKLGTWTYLGEMLVS
Newman LAAFIESKVPDVEIKSMVDTGVLSDRAVAERAGLGFVGRNGFVINPKLGTWTYLGEMLVS
USA300_FPR3757 LAAFIESKVPDVEIKSMVDTGVLSDRAVAERAGLGFVGRNGFVINPKLGTWTYLGEMLVS
************************************************************
COL IPFEPDDPLLDSCGDCTICVDRCPTSALVGNGQLNSQKCISFLTQTKGYMPDQYRYKIGN
N315 IPFEPDDPLLDSCGDCTICVDRCPTSALVGNGQLNSQKCISFLTQTKGYMPDQYRYKIGN
NCTC8325 IPFEPDDPLLDSCGDCTICVDRCPTSALVGNGQLNSQKCISFLTQTKGYMPDQYRYKIGN
Newman IPFEPDDPLLDSCGDCTICVDRCPTSALVGNGQLNSQKCISFLTQTKGYMPDQYRYKIGN
USA300_FPR3757 IPFEPDDPLLDSCGDCTICVDRCPTSALVGNGQLNSQKCISFLTQTKGYMPDQYRYKIGN
************************************************************
COL RLYGCDTCQQVCPKNRGINTEQDDIILEPEILKPRLVPLLRMSNKEFKQTYGHLAGAWRG
N315 RLYGCDTCQQVCPKNRGINTEQDDIILEPEILKPRLVPLLRMSNKEFKQTYGHLAGAWRG
NCTC8325 RLYGCDTCQQVCPKNRGINTEQDDIILEPEILKPRLVPLLRMSNKEFKQTYGHLAGAWRG
Newman RLYGCDTCQQVCPKNRGINTEQDDIILEPEILKPRLVPLLRMSNKEFKQTYGHLAGAWRG
USA300_FPR3757 RLYGCDTCQQVCPKNRGINTEQDDIILEPEILKPRLVPLLRMSNKEFKQTYGHLAGAWRG
************************************************************
COL KKPIQRNAILALAHFNEVDAIPELKKVATTDERPLIRATAYWAIGQILGEEARDFINANY
N315 KKPIQRNAILALAHFNEVDAIPELKKVATTDERPMIRATAYWAIGQILGEEARDFINANY
NCTC8325 KKPIQRNAILALAHFNEVDAIPELKKVATTDERPLIRATAYWAIGQILGEEARDFINANY
Newman KKPIQRNAILALAHFNEVDAIPELKKVATTDERPLIRATAYWAIGQILGEEARDFINANY
USA300_FPR3757 KKPIQRNAILALAHFNEVDAIPELKKVATTDERPLIRATAYWAIGQILGEEARDFINANY
**********************************:*************************
COL DQEDAEVQNEMIKGLDTRRE
N315 DQEDAEVQNEMIKGLDTRRE
NCTC8325 DQEDAEVQNEMIKGLDTRRE
Newman DQEDAEVQNEMIKGLDTRRE
USA300_FPR3757 DQEDAEVQNEMIKGLDTRRE
********************
- ↑ Geoffrey Hutinet, Manal A Swarjo, Valérie de Crécy-Lagard
Deazaguanine derivatives, examples of crosstalk between RNA and DNA modification pathways.
RNA Biol: 2017, 14(9);1175-1184
[PubMed:27937735] [WorldCat.org] [DOI] (I p)Laura Antoine, Philippe Wolff, Eric Westhof, Pascale Romby, Stefano Marzi
Mapping post-transcriptional modifications in Staphylococcus aureus tRNAs by nanoLC/MSMS.
Biochimie: 2019, 164;60-69
[PubMed:31295507] [WorldCat.org] [DOI] (I p)Jorge Díaz-Rullo, José Eduardo González-Pastor
tRNA queuosine modification is involved in biofilm formation and virulence in bacteria.
Nucleic Acids Res: 2023, 51(18);9821-9837
[PubMed:37638766] [WorldCat.org] [DOI] (I p)Valérie de Crécy-Lagard, Geoffrey Hutinet, José D D Cediel-Becerra, Yifeng Yuan, Rémi Zallot, Marc G Chevrette, R M Madhushi N Ratnayake, Marshall Jaroch, Samia Quaiyum, Steven Bruner
Biosynthesis and function of 7-deazaguanine derivatives in bacteria and phages.
Microbiol Mol Biol Rev: 2024, 88(1);e0019923
[PubMed:38421302] [WorldCat.org] [DOI] (I p)