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⊟Summary[edit | edit source]
- pan ID?: SAUPAN004561000
- symbol?: splE
- synonym:
- description?: serine protease SplE
- serine protease SplE
- serine protease SplD
- serine protease SplB
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 4793048..4793764
- synteny block?: BlockID0035500
- occurrence?: in 32% of 34 strains
splE : staphylococcal serine protease SplE [1]
• A crystal structure is available : 5MM8
⊟Orthologs[edit | edit source]
04-02981:
—
08BA02176:
—
11819-97:
—
6850:
—
71193:
—
ECT-R 2:
—
ED133:
—
ED98:
—
HO 5096 0412:
—
JH1:
—
JH9:
—
JKD6008:
—
JKD6159:
—
JSNZ:
JSNZ_001805 (splD)
LGA251:
SARLGA251_16930 (splE)
M013:
—
MRSA252:
SAR1902 (splE)
MSHR1132:
—
MSSA476:
—
Mu3:
—
Mu50:
—
MW2:
—
RF122:
—
ST398:
—
T0131:
—
TCH60:
HMPREF0772_11333 (splB4)
TW20:
SATW20_18070 (splE)
USA300_TCH1516:
USA300HOU_1802 (splE)
VC40:
SAVC_08285
⊟Genome Viewer[edit | edit source]
| COL | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MNKNIIIKSIAALTILTSVTGVGTTVVEGIQQTAKAEHNVKLIKNTNVAPYNGVVSIGSG
NCTC8325 MNKNIIIKSIAALTILTSVTGVGTTVVEGIQQTAKAEHNVKLIKNTNVAPYNGVVSIGSG
Newman MNKNIIIKSIAALTILTSVTGVGTTVVEGIQQTAKAEHNVKLIKNTNVAPYNGVVSIGSG
USA300_FPR3757 MNKNIIIKSIAALTILTSVTGVGTTVVEGIQQTAKAEHNVKLIKNTNVAPYNGVVSIGSG
************************************************************
COL TGFIVGKNTIVTNKHVVAGMEIGAHIIAHPNGEYNNGGFYKVKKIVRYSGQEDIAILHVE
NCTC8325 TGFIVGKNTIVTNKHVVAGMEIGAHIIAHPNGEYNNGGFYKVKKIVRYSGQEDIAILHVE
Newman TGFIVGKNTIVTNKHVVAGMEIGAHIIAHPNGEYNNGGFYKVKKIVRYSGQEDIAILHVE
USA300_FPR3757 TGFIVGKNTIVTNKHVVAGMEIGAHIIAHPNGEYNNGGFYKVKKIVRYSGQEDIAILHVE
************************************************************
COL DKAVHPKNRNFKDYTGILKIASEAKENERISIVGYPEPYINKFQMYESTGKVLSVKGNMI
NCTC8325 DKAVHPKNRNFKDYTGILKIASEAKENERISIVGYPEPYINKFQMYESTGKVLSVKGNMI
Newman DKAVHPKNRNFKDYTGILKIASEAKENERISIVGYPEPYINKFQMYESTGKVLSVKGNMI
USA300_FPR3757 DKAVHPKNRNFKDYTGILKIASEAKENERISIVGYPEPYINKFQMYESTGKVLSVKGNMI
************************************************************
COL ITDAFVEPGNSGSAVFNSKYEVVGVHFGGNGPGNKSTKGYGVYFSPEIKKFIADNTDK
NCTC8325 ITDAFVEPGNSGSAVFNSKYEVVGVHFGGNGPGNKSTKGYGVYFSPEIKKFIADNTDK
Newman ITDAFVEPGNSGSAVFNSKYEVVGVHFGGNGPGNKSTKGYGVYFSPEIKKFIADNTDK
USA300_FPR3757 ITDAFVEPGNSGSAVFNSKYEVVGVHFGGNGPGNKSTKGYGVYFSPEIKKFIADNTDK
**********************************************************
- ↑ Natalia Stach, Magdalena Kalinska, Michal Zdzalik, Radoslaw Kitel, Abdulkarim Karim, Karol Serwin, Wioletta Rut, Katrine Larsen, Abeer Jabaiah, Magdalena Firlej, Benedykt Wladyka, Patrick Daugherty, Henning Stennicke, Marcin Drag, Jan Potempa, Grzegorz Dubin
Unique Substrate Specificity of SplE Serine Protease from Staphylococcus aureus.
Structure: 2018, 26(4);572-579.e4
[PubMed:29526434] [WorldCat.org] [DOI] (I p)Franziska Scherr, Murthy N Darisipudi, Friedemann R Börner, Sophie Austermeier, Franziska Hoffmann, Martin Eberhardt, Goran Abdurrahman, Christopher Saade, Ferdinand von Eggeling, Lydia Kasper, Silva Holtfreter, Barbara M Bröker, Michael Kiehntopf
Alpha-1-antitrypsin as novel substrate for S. aureus' Spl proteases - implications for virulence.
Front Immunol: 2024, 15;1481181
[PubMed:39628483] [WorldCat.org] [DOI] (I e)