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⊟Summary[edit | edit source]
- pan ID?: SAUPAN004252000
- symbol?: —
- synonym:
- description?: ribosomal-processing cysteine protease Prp
- ribosomal-processing cysteine protease Prp
- hypothetical protein with DUF464
- ribosome-associated protein
- YsxB like protein
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 4500090..4500290
- synteny block?: BlockID0032800
- occurrence?: in 100% of 34 strains
prp : ribosome-processing cysteine protease Prp [1]
• A crystal structure is available : 7KLD
The 50S ribosomal large subunit has several processing checkpoints to ensure proper assembly before advancing to a larger multiprotein complex. One of these checkpoints occurs after binding of subunit L27 which has an N-terminal extension that, while required for L27 incorporation, blocks further 50S ribosome assembly. Ribosome-processing cysteine protease (Prp) cleaves this N-terminal extension from immature 50S ribosomes, clearing the L27 checkpoint and allowing 50S macromolecular assembly to continue.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1604
08BA02176:
C248_1689
11819-97:
MS7_1661
6850:
RSAU_001507
71193:
ST398NM01_1709
ECT-R 2:
ECTR2_1494
ED133:
SAOV_1643
ED98:
SAAV_1639
HO 5096 0412:
SAEMRSA15_15630
JH1:
SaurJH1_1736
JH9:
SaurJH9_1703
JKD6008:
SAA6008_01615
JKD6159:
SAA6159_01578
JSNZ:
JSNZ_001636
LGA251:
SARLGA251_15480
M013:
M013TW_1666
MRSA252:
SAR1726
MSHR1132:
SAMSHR1132_14820
MSSA476:
SAS1582
Mu3:
SAHV_1633
Mu50:
SAV1646
MW2:
MW1596
RF122:
SAB1515c
ST398:
SAPIG1709
T0131:
SAT0131_01747
TCH60:
HMPREF0772_11496
TW20:
SATW20_16400
USA300_TCH1516:
USA300HOU_1645
VC40:
SAVC_07475
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MITVDITVNDEGKVTDVIMDGHADHGEYGHDIVCAGASAVLFGSVNAIIGLTSERPDINY
N315 MITVDITVNDEGKVTDVIMDGHADHGEYGHDIVCAGASAVLFGSVNAIIGLTSERPDINY
NCTC8325 MITVDITVNDEGKVTDVIMDGHADHGEYGHDIVCAGASAVLFGSVNAIIGLTSERPDINY
Newman MITVDITVNDEGKVTDVIMDGHADHGEYGHDIVCAGASAVLFGSVNAIIGLTSERPDINY
USA300_FPR3757 MITVDITVNDEGKVTDVIMDGHADHGEYGHDIVCAGASAVLFGSVNAIIGLTSERPDINY
************************************************************
COL DDNGGHFHIRSVDTNNDEAQLILQTMLVSLQTIEEEYNENIRLNYK
N315 DDNGGHFHIRSVDTNNDEAQLILQTMLVSLQTIEEEYNENIRLNYK
NCTC8325 DDNGGHFHIRSVDTNNDEAQLILQTMLVSLQTIEEEYNENIRLNYK
Newman DDNGGHFHIRSVDTNNDEAQLILQTMLVSLQTIEEEYNENIRLNYK
USA300_FPR3757 DDNGGHFHIRSVDTNNDEAQLILQTMLVSLQTIEEEYNENIRLNYK
**********************************************
- ↑ Erin A Wall, Adam L Johnson, Darrell L Peterson, Gail E Christie
Structural modeling and functional analysis of the essential ribosomal processing protease Prp from Staphylococcus aureus.
Mol Microbiol: 2017, 104(3);520-532
[PubMed:28187498] [WorldCat.org] [DOI] (I p)