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⊟Summary[edit | edit source]
- pan ID?: SAUPAN004246000
- symbol?: queA
- synonym:
- description?: tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA
- tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA
- S-adenosylmethionine:tRNA ribosyltransferase-isomerase
- S-adenosylmethionine--tRNA ribosyltransferase-isomerase
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 4493903..4494928
- synteny block?: BlockID0032740
- occurrence?: in 100% of 34 strains
queA : preQ1(34) S-adenosylmethionine:tRNA ribosyltransferase-isomerase [1]
Several transfer RNAs require modifications to provide maximal fidelity during protein synthesis. QueA modifies tRNA preQ1(34) nucleobases (originally guanosine(34) nucleobases modified by tRNA guanosine(34) transglycosylase) with a ribosyl group originating from S-adenosylmethionine and then isomerizing that nucleobase into tRNA epoxyqueosine(34). Staphylococcal tRNAs requiring this modification include: tRNAHGUG, tRNAYGUA, tRNANGUU, tRNADGUC.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1598 (queA)
08BA02176:
C248_1683 (queA)
11819-97:
MS7_1655 (queA)
6850:
RSAU_001501 (queA)
71193:
ST398NM01_1703
ECT-R 2:
ECTR2_1488 (queA)
ED133:
SAOV_1637 (queA)
ED98:
SAAV_1633 (queA)
HO 5096 0412:
SAEMRSA15_15570 (queA)
JH1:
SaurJH1_1730 (queA)
JH9:
SaurJH9_1697 (queA)
JKD6008:
SAA6008_01609 (queA)
JKD6159:
SAA6159_01572 (queA)
JSNZ:
JSNZ_001630 (queA)
LGA251:
SARLGA251_15420 (queA)
M013:
M013TW_1660
MRSA252:
SAR1720 (queA)
MSHR1132:
SAMSHR1132_14760
MSSA476:
SAS1576 (queA)
Mu3:
SAHV_1627 (queA)
Mu50:
SAV1640 (queA)
MW2:
MW1590 (queA)
RF122:
SAB1509c (queA)
ST398:
SAPIG1703 (queA)
T0131:
SAT0131_01740
TCH60:
HMPREF0772_11502 (queA)
TW20:
SATW20_16340 (queA)
USA300_TCH1516:
USA300HOU_1639 (queA)
VC40:
SAVC_07445 (queA)
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MNIEEFDYDLPESLIAQTPLKDRDHSRLLVMDRETGEMKHLHFKDIIEYFRPGDTLVLND
N315 MNIEEFDYDLPESLIAQTPLKDRDHSRLLVMDRETGEMKHLHFKDIIEYFRPGDTLVLND
NCTC8325 MNIEEFDYDLPESLIAQTPLKDRDHSRLLVMDRETGEMKHLHFKDIIEYFRPGDTLVLND
Newman MNIEEFDYDLPESLIAQTPLKDRDHSRLLVMDRETGEMKHLHFKDIIEYFRPGDTLVLND
USA300_FPR3757 MNIEEFDYDLPESLIAQTPLKDRDHSRLLVMDRETGEMKHLHFKDIIEYFRPGDTLVLND
************************************************************
COL TRVMPARLFGLKEETGAKVEMLMLTQIEGNDWEVLLKPAKRIKVGNKLNFGNGKIIAECI
N315 TRVMPARLFGLKEETGAKVEMLMLTQIEGNDWEVLLKPAKRIKVGNKLNFGNGKIIAECI
NCTC8325 TRVMPARLFGLKEETGAKVEMLMLTQIEGNDWEVLLKPAKRIKVGNKLNFGNGKIIAECI
Newman TRVMPARLFGLKEETGAKVEMLMLTQIEGNDWEVLLKPAKRIKVGNKLNFGNGKIIAECI
USA300_FPR3757 TRVMPARLFGLKEETGAKVEMLMLTQIEGNDWEVLLKPAKRIKVGNKLNFGNGKIIAECI
************************************************************
COL KEMDQGGRIMRLHYEGILQERLDELGEMPLPPYIKERLDDPDRYQTVYAKESGSAAAPTA
N315 KEMDQGGRIMRLHYEGILQERLDELGEMPLPPYIKERLDDPDRYQTVYAKESGSAAAPTA
NCTC8325 KEMDQGGRIMRLHYEGILQERLDELGEMPLPPYIKERLDDPDRYQTVYAKESGSAAAPTA
Newman KEMDQGGRIMRLHYEGILQERLDELGEMPLPPYIKERLDDPDRYQTVYAKESGSAAAPTA
USA300_FPR3757 KEMDQGGRIMRLHYEGILQERLDELGEMPLPPYIKERLDDPDRYQTVYAKESGSAAAPTA
************************************************************
COL GLHFTDELLIEIKNKGVNIAFVTLHVGLGTFRPVSVDDVNDHEMHSEYYQMTQETADLLN
N315 GLHFTDELLTEIKNKGVNIAFVTLHVGLGTFRPVSVDDVNDHEMHSEYYQMTQETADLLN
NCTC8325 GLHFTDELLIEIKNKGVNIAFVTLHVGLGTFRPVSVDDVNDHEMHSEYYQMTQETADLLN
Newman GLHFTDELLIEIKNKGVNIAFVTLHVGLGTFRPVSVDDVNDHEMHSEYYQMTQETADLLN
USA300_FPR3757 GLHFTDELLIEIKNKGVNIAFVTLHVGLGTFRPVSVDDVNDHEMHSEYYQMTQETADLLN
********* **************************************************
COL DTKSKGHRIISVGTTSTRTLETIRRDHDKFVETSGWTNIFIYPGFDFKAIDGQITNFHLP
N315 DTKSKGHRIISVGTTSTRTLETIRRDHDKFVETSGWTNIFIYPGFDFKAIDGQITNFHLP
NCTC8325 DTKSKGHRIISVGTTSTRTLETIRRDHDKFVETSGWTNIFIYPGFDFKAIDGQITNFHLP
Newman DTKSKGHRIISVGTTSTRTLETIRRDHDKFVETSGWTNIFIYPGFDFKAIDGQITNFHLP
USA300_FPR3757 DTKSKGHRIISVGTTSTRTLETIRRDHDKFVETSGWTNIFIYPGFDFKAIDGQITNFHLP
************************************************************
COL KSTLVMLVSAFSSRENVLNAYKTAVNLEYRFFSFGDAMLII
N315 KSTLVMLVSAFSTRENVLNAYKTAVNLEYRFFSFGDAMLII
NCTC8325 KSTLVMLVSAFSSRENVLNAYKTAVNLEYRFFSFGDAMLII
Newman KSTLVMLVSAFSSRENVLNAYKTAVNLEYRFFSFGDAMLII
USA300_FPR3757 KSTLVMLVSAFSSRENVLNAYKTAVNLEYRFFSFGDAMLII
************:****************************
- ↑ Geoffrey Hutinet, Manal A Swarjo, Valérie de Crécy-Lagard
Deazaguanine derivatives, examples of crosstalk between RNA and DNA modification pathways.
RNA Biol: 2017, 14(9);1175-1184
[PubMed:27937735] [WorldCat.org] [DOI] (I p)Laura Antoine, Philippe Wolff, Eric Westhof, Pascale Romby, Stefano Marzi
Mapping post-transcriptional modifications in Staphylococcus aureus tRNAs by nanoLC/MSMS.
Biochimie: 2019, 164;60-69
[PubMed:31295507] [WorldCat.org] [DOI] (I p)Jorge Díaz-Rullo, José Eduardo González-Pastor
tRNA queuosine modification is involved in biofilm formation and virulence in bacteria.
Nucleic Acids Res: 2023, 51(18);9821-9837
[PubMed:37638766] [WorldCat.org] [DOI] (I p)Valérie de Crécy-Lagard, Geoffrey Hutinet, José D D Cediel-Becerra, Yifeng Yuan, Rémi Zallot, Marc G Chevrette, R M Madhushi N Ratnayake, Marshall Jaroch, Samia Quaiyum, Steven Bruner
Biosynthesis and function of 7-deazaguanine derivatives in bacteria and phages.
Microbiol Mol Biol Rev: 2024, 88(1);e0019923
[PubMed:38421302] [WorldCat.org] [DOI] (I p)