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⊟Summary[edit | edit source]
- pan ID?: SAUPAN004236000
- symbol?: hisS
- synonym:
- description?: histidine--tRNA ligase
- histidine--tRNA ligase
- histidyl-tRNA synthetase
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 4481198..4482460
- synteny block?: BlockID0032640
- occurrence?: in 100% of 34 strains
hisS : histidyl-tRNA synthetase [1]
• A crystal structure is available : 1QE0
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1589 (hisS)
08BA02176:
C248_1674 (hisS)
11819-97:
MS7_1646 (hisS)
6850:
RSAU_001492 (hisS)
71193:
ST398NM01_1694
ECT-R 2:
ECTR2_1479 (hisS)
ED133:
SAOV_1628 (hisS)
ED98:
SAAV_1624 (hisS)
HO 5096 0412:
SAEMRSA15_15480 (hisS)
JH1:
SaurJH1_1721 (hisS)
JH9:
SaurJH9_1688 (hisS)
JKD6008:
SAA6008_01600 (hisS)
JKD6159:
SAA6159_01563 (hisS)
JSNZ:
JSNZ_001621 (hisS)
LGA251:
SARLGA251_15330 (hisS)
M013:
M013TW_1651
MRSA252:
SAR1711 (hisS)
MSHR1132:
SAMSHR1132_14670
MSSA476:
SAS1567 (hisS)
Mu3:
SAHV_1618 (hisS)
Mu50:
SAV1631 (hisS)
MW2:
MW1581 (hisS)
RF122:
SAB1500c (hisS)
ST398:
SAPIG1694 (hisS)
T0131:
SAT0131_01729 (sdrD)
TCH60:
HMPREF0772_11511 (hisS)
TW20:
SATW20_16250 (hisS)
USA300_TCH1516:
USA300HOU_1629 (hisS)
VC40:
SAVC_07400 (hisS)
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MIKIPRGTQDILPEDSKKWRYIENQLDELMTFYNYKEIRTPIFESTDLFARGVGDSTDVV
N315 MIKIPRGTQDILPEDSKKWRYIENQLDELMTFYNYKEIRTPIFESTDLFARGVGDSTDVV
NCTC8325 MIKIPRGTQDILPEDSKKWRYIENQLDELMTFYNYKEIRTPIFESTDLFARGVGDSTDVV
Newman MIKIPRGTQDILPEDSKKWRYIENQLDELMTFYNYKEIRTPIFESTDLFARGVGDSTDVV
USA300_FPR3757 MIKIPRGTQDILPEDSKKWRYIENQLDELMTFYNYKEIRTPIFESTDLFARGVGDSTDVV
************************************************************
COL QKEMYTFKDKGDRSITLRPEGTAAVVRSYIEHKMQGNPNQPIKLYYNGPMFRYERKQKGR
N315 QKEMYTFKDKGDRSITLRPEGTAAVVRSYIEHKMQGNPNQPIKLYYNGPMFRYERKQKGR
NCTC8325 QKEMYTFKDKGDRSITLRPEGTAAVVRSYIEHKMQGNPNQPIKLYYNGPMFRYERKQKGR
Newman QKEMYTFKDKGDRSITLRPEGTAAVVRSYIEHKMQGNPNQPIKLYYNGPMFRYERKQKGR
USA300_FPR3757 QKEMYTFKDKGDRSITLRPEGTAAVVRSYIEHKMQGNPNQPIKLYYNGPMFRYERKQKGR
************************************************************
COL YRQFNQFGVEAIGAENPSVDAEVLAMVMHIYQSFGLKHLKLVINSVGDMASRKEYNEALV
N315 YRQFNQFGVEAIGAENPSVDAEVLAMVMHIYQSFGLKHLKLVINSVGDMASRKEYNEALV
NCTC8325 YRQFNQFGVEAIGAENPSVDAEVLAMVMHIYQSFGLKHLKLVINSVGDMASRKEYNEALV
Newman YRQFNQFGVEAIGAENPSVDAEVLAMVMHIYQSFGLKHLKLVINSVGDMASRKEYNEALV
USA300_FPR3757 YRQFNQFGVEAIGAENPSVDAEVLAMVMHIYQSFGLKHLKLVINSVGDMASRKEYNEALV
************************************************************
COL KHFEPVIHEFCSDCQSRLHTNPMRILDCKVDRDKEAIKTAPRITDFLNEESKAYYEQVKA
N315 KHFEPVIHEFCSDCQSRLHTNPMRILDCKVDRDKEAIKTAPRITDFLNEESKAYYEQVKA
NCTC8325 KHFEPVIHEFCSDCQSRLHTNPMRILDCKVDRDKEAIKTAPRITDFLNEESKAYYEQVKA
Newman KHFEPVIHEFCSDCQSRLHTNPMRILDCKVDRDKEAIKTAPRITDFLNEESKAYYEQVKA
USA300_FPR3757 KHFEPVIHEFCSDCQSRLHTNPMRILDCKVDRDKEAIKTAPRITDFLNEESKAYYEQVKA
************************************************************
COL YLDDLGIPYIEDPNLVRGLDYYTHTAFELMMDNPNYDGAITTLCGGGRYNGLLELLDGPS
N315 YLDDLGIPYIEDPNLVRGLDYYTHTAFELMMDNPNYDGAITTLCGGGRYNGLLELLDGPS
NCTC8325 YLDDLGIPYIEDPNLVRGLDYYTHTAFELMMDNPNYDGAITTLCGGGRYNGLLELLDGPS
Newman YLDDLGIPYIEDPNLVRGLDYYTHTAFELMMDNPNYDGAITTLCGGGRYNGLLELLDGPS
USA300_FPR3757 YLDDLGIPYIEDPNLVRGLDYYTHTAFELMMDNPNYDGAITTLCGGGRYNGLLELLDGPS
************************************************************
COL ETGIGFALSIERLLLALEEEGIELDIEENLDLFIVTMGDQADRYAVKLLNHLRHNGIKAD
N315 ETGIGFALSIERLLLALEEEGIELDIEENLDLFIVTMGDQADRYAVKLLNHLRHNGIKAD
NCTC8325 ETGIGFALSIERLLLALEEEGIELDIEENLDLFIVTMGDQADRYAVKLLNHLRHNGIKAD
Newman ETGIGFALSIERLLLALEEEGIELDIEENLDLFIVTMGDQADRYAVKLLNHLRHNGIKAD
USA300_FPR3757 ETGIGFALSIERLLLALEEEGIELDIEENLDLFIVTMGDQADRYAVKLLNHLRHNGIKAD
************************************************************
COL KDYLQRKIKGQMKQADRLGAKFTIVIGDQELENNKIDVKNMTTGESETIELDALVEYFKK
N315 KDYLQRKIKGQMKQADRLGAKFTIVIGDQELENNKIDVKNMTTGESETIELDALVEYFKK
NCTC8325 KDYLQRKIKGQMKQADRLGAKFTIVIGDQELENNKIDVKNMTTGESETIELDALVEYFKK
Newman KDYLQRKIKGQMKQADRLGAKFTIVIGDQELENNKIDVKNMTTGESETIELDALVEYFKK
USA300_FPR3757 KDYLQRKIKGQMKQADRLGAKFTIVIGDQELENNKIDVKNMTTGESETIELDALVEYFKK
************************************************************
- ↑ X Qiu, C A Janson, M N Blackburn, I K Chhohan, M Hibbs, S S Abdel-Meguid
Cooperative structural dynamics and a novel fidelity mechanism in histidyl-tRNA synthetases.
Biochemistry: 1999, 38(38);12296-304
[PubMed:10493797] [WorldCat.org] [DOI] (P p)A K Forrest, R L Jarvest, L M Mensah, P J O'Hanlon, A J Pope, R J Sheppard
Aminoalkyl adenylate and aminoacyl sulfamate intermediate analogues differing greatly in affinity for their cognate Staphylococcus aureus aminoacyl tRNA synthetases.
Bioorg Med Chem Lett: 2000, 10(16);1871-4
[PubMed:10969988] [WorldCat.org] [DOI] (P p)