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⊟Summary[edit | edit source]
- pan ID?: SAUPAN004228000
- symbol?: cymR
- synonym:
- description?: Rrf2 family transcriptional regulator
- Rrf2 family transcriptional regulator
- Rrf2 family protein
- transcriptional regulator, putative
- BadM/Rrf2 family transcriptional regulator
- HTH-type transcriptional regulator CymR
- Iron-sulfur cluster regulator IscR
- Rfr2 family transcriptional regulator
- rrf2 family protein (transcriptional regulator) family protein
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 4476189..4476612
- synteny block?: BlockID0032560
- occurrence?: in 97% of 34 strains
cymR : cysteine metabolism and oxidative stress response transcriptional repressor CymR [1]
• A crystal structure is available: 3T8R
• The CymR Regulon consists of Twenty-One Genes
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1584 (iscR)
08BA02176:
C248_1668
11819-97:
MS7_1642 (cymR)
6850:
RSAU_001488
71193:
ST398NM01_1690
ECT-R 2:
ECTR2_1475
ED133:
SAOV_1624
ED98:
SAAV_1619
HO 5096 0412:
SAEMRSA15_15440
JH1:
SaurJH1_1717
JH9:
SaurJH9_1684
JKD6008:
SAA6008_01596
JKD6159:
SAA6159_01559
JSNZ:
JSNZ_001615
LGA251:
SARLGA251_15290
M013:
M013TW_1647
MRSA252:
SAR1706
MSHR1132:
SAMSHR1132_14630
MSSA476:
SAS1562
Mu3:
SAHV_1613
Mu50:
SAV1626
MW2:
MW1576
RF122:
SAB1496c
ST398:
SAPIG1690
T0131:
SAT0131_01723
TCH60:
HMPREF0772_11515
TW20:
SATW20_16210
USA300_TCH1516:
—
VC40:
SAVC_07380
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKISTKGRYGLTLMISLAKKEGQGCISLKSIAEENNLSDLYLEQLVGPLRNAGLIRSVRG
N315 MKISTKGRYGLTLMISLAKKEGQGCISLKSIAEENNLSDLYLEQLVGPLRNAGLIRSVRG
NCTC8325 MKISTKGRYGLTLMISLAKKEGQGCISLKSIAEENNLSDLYLEQLVGPLRNAGLIRSVRG
Newman MKISTKGRYGLTLMISLAKKEGQGCISLKSIAEENNLSDLYLEQLVGPLRNAGLIRSVRG
USA300_FPR3757 MKISTKGRYGLTLMISLAKKEGQGCISLKSIAEENNLSDLYLEQLVGPLRNAGLIRSVRG
************************************************************
COL AKGGYQLRVPAEEISAGDIIRLLEGPITFVESIESEPPAQKQLWIRMRDAVRDVLDNTTL
N315 AKGGYQLRVPAEEISAGDIIRLLEGPITFVESIESEPPAQKQLWIRMRDAVRDVLDNTTL
NCTC8325 AKGGYQLRVPAEEISAGDIIRLLEGPITFVESIESEPPAQKQLWIRMRDAVRDVLDNTTL
Newman AKGGYQLRVPAEEISAGDIIRLLEGPITFVESIESEPPAQKQLWIRMRDAVRDVLDNTTL
USA300_FPR3757 AKGGYQLRVPAEEISAGDIIRLLEGPITFVESIESEPPAQKQLWIRMRDAVRDVLDNTTL
************************************************************
COL KYLAEYVDTSEDLDGYMFYI
N315 KYLAEYVDTSEDLDGYMFYI
NCTC8325 KYLAEYVDTSEDLDGYMFYI
Newman KYLAEYVDTSEDLDGYMFYI
USA300_FPR3757 KYLAEYVDTSEDLDGYMFYI
********************
- ↑ Olga Soutourina, Olivier Poupel, Jean-Yves Coppée, Antoine Danchin, Tarek Msadek, Isabelle Martin-Verstraete
CymR, the master regulator of cysteine metabolism in Staphylococcus aureus, controls host sulphur source utilization and plays a role in biofilm formation.
Mol Microbiol: 2009, 73(2);194-211
[PubMed:19508281] [WorldCat.org] [DOI] (I p)Quanjiang Ji, Liang Zhang, Fei Sun, Xin Deng, Haihua Liang, Taeok Bae, Chuan He
Staphylococcus aureus CymR is a new thiol-based oxidation-sensing regulator of stress resistance and oxidative response.
J Biol Chem: 2012, 287(25);21102-9
[PubMed:22553203] [WorldCat.org] [DOI] (I p)Jose Antonio Ibarra, Ernesto Pérez-Rueda, Ronan K Carroll, Lindsey N Shaw
Global analysis of transcriptional regulators in Staphylococcus aureus.
BMC Genomics: 2013, 14;126
[PubMed:23442205] [WorldCat.org] [DOI] (I e)