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⊟Summary[edit | edit source]
- pan ID?: SAUPAN003449000
- symbol?: mraW
- synonym:
- description?: S-adenosyl-methyltransferase MraW
- S-adenosyl-methyltransferase MraW
- ribosomal RNA small subunit methyltransferase H
- 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH
- 16S rRNA (cytosine(1402)-N(4))-methyltransferase
- 16S rRNA m(4)C1402 methyltransferase
- MraW methylase family protein
- rRNA small subunit methyltransferase H
- S-adenosyl-L-methionine-dependent methyltransferase mraW
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 3792477..3793412
- synteny block?: BlockID0025290
- occurrence?: in 100% of 34 strains
rsmH (mraW) : ribosome small subunit methyltransferase H [1]
Ribosome small subunit methyltransferase H (alt: ribosome small subunit nucleobase methyltransferase H, 16S rRNA cytosine (1412)-N-(4)-methyltransferase) attaches a methyl group to the cytosine nucleobase at the 4-position of residue 1412 in 16S ribosomal RNA (S. aureus numbering; cytosine 1402 by E. coli numbering).
- 16S rRNA : C (1412) → m4C (1412)
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1137 (mraW)
08BA02176:
C248_1208
11819-97:
MS7_1136 (mraW)
6850:
RSAU_001060 (mraW)
71193:
ST398NM01_1176
ECT-R 2:
ECTR2_1035 (mraW)
ED133:
SAOV_1180
ED98:
SAAV_1150 (mraW)
HO 5096 0412:
SAEMRSA15_10120
JH1:
SaurJH1_1263 (mraW)
JH9:
SaurJH9_1238 (mraW)
JKD6008:
SAA6008_01133 (mraW)
JKD6159:
SAA6159_01030 (mraW)
JSNZ:
JSNZ_001148 (rsmH)
LGA251:
SARLGA251_10900
M013:
M013TW_1113
MRSA252:
SAR1155 (mraW)
MSHR1132:
SAMSHR1132_10210
MSSA476:
SAS1113 (mraW)
Mu3:
SAHV_1169 (mraW)
Mu50:
SAV1179 (mraW)
MW2:
MW1062 (mraW)
RF122:
SAB1043 (mraW)
ST398:
SAPIG1176 (mraW)
T0131:
SAT0131_01224 (rpsC)
TCH60:
HMPREF0772_12053 (mraW)
TW20:
SATW20_11730
USA300_TCH1516:
USA300HOU_1119 (mraW)
VC40:
SAVC_05060
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MFHHISVMLNETIDYLNVKENGVYIDCTLGGAGHALYLLNQLNDDGRLIAIDQDQTAIDN
N315 MFHHISVMLNETIDYLNVKENGVYIDCTLGGAGHALYLLNQLNDDGRLIAIDQDQTAIDN
NCTC8325 -------MLNETIDYLNVKENGVYIDCTLGGAGHALYLLNQLNDDGRLIAIDQDQTAIDN
Newman MFHHISVMLNETIDYLNVKENGVYIDCTLGGAGHALYLLNQLNDDGRLIAIDQDQTAIDN
USA300_FPR3757 -------MLNETIDYLNVKENGVYIDCTLGGAGHALYLLNQLNDDGRLIAIDQDQTAIDN
*****************************************************
COL AKEVLKDHLHRVTFVHSNFRELTQILKDLNIEKVDGIYYDLGVSSPQLDIPERGFSYHHD
N315 AKEVLKDHLHKVTFVHSNFRELTQILKDLNIEKVDGIYYDLGVSSPQLDIPERGFSYHHD
NCTC8325 AKEVLKDHLHKVTFVHSNFRELTQILKDLNIEKVDGIYYDLGVSSPQLDIPERGFSYHHD
Newman AKEVLKDHLHRVTFVHSNFRELTQILKDLNIEKVDGIYYDLGVSSPQLDIPERGFSYHHD
USA300_FPR3757 AKEVLKDHLHKVTFVHSNFRELTQILKDLNIEKVDGIYYDLGVSSPQLDIPERGFSYHHD
**********:*************************************************
COL ATLDMRMDQTQELTAYEIVNNWSYEALVKIFYRYGEEKFSKQIARRIEAHREQQPITTTL
N315 ATLDMRMDQTQELTAYEIVNNWSYEALVKIFYRYGEEKFSKQIARRIEAHREQQPITTTL
NCTC8325 ATLDMRMDQTQELTAYEIVNNWSYEALVKIFYRYGEEKFSKQIARRIEAHREQQPITTTL
Newman ATLDMRMDQTQELTAYEIVNNWSYEALVKIFYRYGEEKFSKQIARRIEAHREQQPITTTL
USA300_FPR3757 ATLDMRMDQTQELTAYEIVNNWSYEALVKIFYRYGEEKFSKQIARRIEAHREQQPITTTL
************************************************************
COL ELVDIIKEGIPAKARRKGGHPAKRVFQALRIAVNDELSAFEDSIEQAIELVKVDGRISVI
N315 ELVDIIKEGIPAKARRKGGHPAKRVFQALRIAVNDELSAFEDSIEQAIELVKVDGRISVI
NCTC8325 ELVDIIKEGIPAKARRKGGHPAKRVFQALRIAVNDELSAFEDSIEQAIELVKVDGRISVI
Newman ELVDIIKEGIPAKARRKGGHPAKRVFQALRIAVNDELSAFEDSIEQAIELVKVDGRISVI
USA300_FPR3757 ELVDIIKEGIPAKARRKGGHPAKRVFQALRIAVNDELSAFEDSIEQAIELVKVDGRISVI
************************************************************
COL TFHSLEDRLCKQVFQEYEKGPEVPRGLPVIPEAYTPKLKRVNRKPITATEEDLDDNNRAR
N315 TFHSLEDRLCKQVFQEYEKGPEVPRGLPVIPEAYTPKLKRVNRKPITATEEDLDDNNRAR
NCTC8325 TFHSLEDRLCKQVFQEYEKGPEVPRGLPVIPEAYTPKLKRVNRKPITATEEDLDDNNRAR
Newman TFHSLEDRLCKQVFQEYEKGPEVPRGLPVIPEAYTPKLKRVNRKPITATEEDLDDNNRAR
USA300_FPR3757 TFHSLEDRLCKQVFQEYEKGPEVPRGLPVIPEAYTPKLKRVNRKPITATEEDLDDNNRAR
************************************************************
COL SAKLRVAEILK
N315 SAKLRVAEILK
NCTC8325 SAKLRVAEILK
Newman SAKLRVAEILK
USA300_FPR3757 SAKLRVAEILK
***********
- ↑ Tatsuhiko Kyuma, Satoshi Kimura, Yuichi Hanada, Tsutomu Suzuki, Kazuhisa Sekimizu, Chikara Kaito
Ribosomal RNA methyltransferases contribute to Staphylococcus aureus virulence.
FEBS J: 2015, 282(13);2570-84
[PubMed:25893373] [WorldCat.org] [DOI] (I p)Alexander Golubev, Bulat Fatkhullin, Iskander Khusainov, Lasse Jenner, Azat Gabdulkhakov, Shamil Validov, Gulnara Yusupova, Marat Yusupov, Konstantin Usachev
Cryo-EM structure of the ribosome functional complex of the human pathogen Staphylococcus aureus at 3.2 Å resolution.
FEBS Lett: 2020, 594(21);3551-3567
[PubMed:32852796] [WorldCat.org] [DOI] (I p)Adrián González-López, Daniel S D Larsson, Ravi Kiran Koripella, Brett N Cain, Martin Garcia Chavez, Paul J Hergenrother, Suparna Sanyal, Maria Selmer
Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane.
Sci Rep: 2024, 14(1);14253
[PubMed:38902339] [WorldCat.org] [DOI] (I e)